Hong Kong Baptist University - School of Chinese Medicine

Dr YUE Kin Man, Kevin

Associate Professor, Teaching Division
Expert in Biochemistry and Diabetes

Dr Yue is an expert in biochemistry and specialized in research of diabetes. His field of study includes complication of diabetes, blood vessel diseases due to diabetes and genetic transformation. Dr Yue graduated from the University of Liverpool, United Kingdom in 1985 and he subsequently obtained his PhD degree in Biochemistry at the same university in 1989. He conducted his post-doctoral research at the Universities of Leicester and Manchester. Before joining the Hong Kong Baptist University, Dr. Yue was a Lecturer in Clinical Biochemistry at the Queen's University of Belfast, United Kingdom. Dr Yue is currently lecturing biomedical subjects such as Anatomy, Physiology and Biochemistry in our School.

With his increasing interest in Chinese medicine, Dr. Yue subsequently pursued further study, and got a bachelor degree in Chinese Medicine at the Hong Kong Baptist University. He is now a registered Chinese Medicine Practitioner. The training has expanded Dr. Yue scope of research and his projects now includes the use of Chinese herbs and formulations in the treatment of diabetic complications, and the basis of the mode of actions of the herbs, using proteomic and metabolomic approaches.

Selected Publications

Yue, K.K.M. and Tse, D.L.Y. (2008). Modulation of glucose-related protein (GRP78) expression in vascular smooth muscle cells cultured in high glucose condition. Diabetes, 57, 203.

Cho, W.C.S., Yip, T-T., Chung, W-S., Lee, S.K.W., Leung, A.W.N., Cheng, C.H.K. and Yue, K.K.M. (2006). Altered expression of serum protein in ginsenoside Re treated diabetic rats detected by SELDI-TOF MS. Journal of Ethnopharmacology, 108, 272-279.

Cho, W.C.S., Chung, W.S., Lee, S.K., Leung, A.W.N., Cheng, C.H.K. and Yue, K.K.M. (2006). Ginsenoside Re of Panax ginseng possess significant antioxidant and antihyperlidemic efficacies in streptozotocin-induce diabetic rats. European Journal of Pharmacology, 550, 173-9.

Cho, W.C.S., Yip, T-T., Chung, W-S., Leung, A.W.N., Cheng, C.H.K. and Yue, K.K.M. (2006). Differential expression of proteins in the kidney, eye, aorta and serum of diabetic and non-diabetic rats. Journal of Cellular Biochemistry, 99, 256-268.

Yue, K.K.M., Lee, K.W., Leung, A.W.N., Chan, K.K.C., Leung, K.S.Y. and Cheng, C.H.K. (2006). Danshen prevents the occurrence of oxidative stress in eyes and aorta of diabetic rats. Journal of Ethnopharmacology, 106, 136-141.

Cho, WCS, Yip, TT, Chung, WS, Leung AWN, Cheng, CHK and Yue, K.K.M. (2006). Potential biomarkers identified by proteomic profiling may provide insight for the macrovascular pathogenesis of diabetes mellitus. Disease Markers, 22, 153-166.

Yue, K.K.M., Cho, William, C.S., Yip, T.T., Chung, W.S., Lee, S.K.W., Leung, Albert, W.N., Cheng, C.H.K. (2006) Altered expression of C-reactive protein in ginsenoside Re treated diabetic rats detected by SELDI-TOF MS. Diabetes, 55, S2, A 577.

Ha, W.Y., Li, X.J., Yue, P.Y.K., Wong, D.Y.L., Yue, K.K.M., Chung, W.S., Zhao, L., Leung, P.Y., Liu, L. and Wong, R.N.S. (2006). Gene expression profiling of human synovial sarcoma cell line (Hs701.T) in response to IL-1 stimulation. Inflammation Research, 55, 1-7.

Tian, Y., Leung, W.N., Yue, K.K.M. and Mak, N.K. (2006). Cell death induced by MPPa-PDT in prostrate carcinoma in vitro and in vivo. Biochemical and Biophysical Research Communication, 348, 413-420.

Yue, K.K.M., Cho, William, C.S., Yip, T.T., Cheng, C.H.K., Leung, Albert, W.N. (2005). Different proteomic profiles in the vascular tissues of diabetic rats. Diabetes, 54, S2, A228.

Yue, K.K.M., Cho, William, C.S., Yip, T.T., Cheng, C.H.K., Leung, Albert, W.N. (2005). Identification of potential biomarkers in the macrovascular pathogenesis of diabetes mellitus. FEBS J., 272, S1, 503.

Yue, K.K.M., Leung, S.N., Man, P.M., Yeung, W.F., Chung, W.S., Lee, K.W., Leung, A.W.N. and Cheng, C.H.K. (2005). Alterations in antioxidant enzyme activities in the eye, aorta and kidney of diabetic rats relevant to the onset of oxidative stress. Life Sciences, 77, 721-34.

Cho, WCS, Yue K.K.M. and Leung AWN (2005). An outline of diabetes mellitus and its treatments by traditional Chinese medicine. Journal of Chinese Medicine, 78, 29-37.

Cho, W.C.S., Yue, K.K.M. and Leung, A.W.N. (2005). Proteomics- Leading the postgenome era. China Biotechnology, 25, 33-38.

Koon, H.K., Leung, A.W.N., Yue, K.K.M. and Mak, N.K. (2005). Photodynamic effect of curcumin on NPC/CNE2 cells. Journal of Environmental Pathology Toxicology and Oncology, 25, 1-11.

Cho, W.C.S., Yue, K.K.M. and Leung, A.W.N. (2004). An outline of obesity and its therapy by Chinese and western medicine. Chinese Journal of Traditional and Western Medicine, 24, 3073-3075.

Yue, K.K.M., Chung, W.S., Leung, A.W.N. and Cheng, C.H.K. (2003). Redox changes precede the occurrence of oxidative stress in eyes and aorta, but not in kidneys of diabetic rats. Life Sciences , 73, 2557-2570.

Sharpe, P.C., Yue, K.K.M., McMaster, D, Catherwood, M.A. and Trimble, E.R. (1998). The Role of Glucose-Induced Oxidative Stress on Growth and Extracellular Matrix Gene Expression of Vascular Smooth Muscle Cells. Diabetologia, 41, 1210-1219.

Sharpe, P.C., Liu, W.H., Yue, K.K.M., McMaster, D, Catherwood, M.A., McGuinty, and Trimble, E.R. (1998). Glucose-Induced Oxidative Stress in Vascular Contractile Cells: Comparison of Aortic Vascular Smooth Muscle Cells and Retinal Capillary Pericytes. Diabetes , 47, 801-809.

Chidgey, M.A.J., Yue, K.K.M., Gould, S, Byrne, C. and Garrod, D.R. (1997). Changing Pattern of Desmocollin 3 Expression Accompanies Epidermal Organisation During Skin Development. Developmental Dynamics, 210, 315-327.

Dmochowski, M, Hashimoto, T., Chidgey, M.AJ., Yue, K.K.M., Wilkinson, R.W., Nishikawa, T. and Garrod, D.R. (1995). Demonstration of Antibodies to Bovine Desmocollin Isoforms in Certain Pemphigus Sera. British Journal of Dermatology, 133, 519-525.

Hashimoto, T., Amagai, M., Watanabe, K., Dmochowski, M., Chidgey, M.A.J., Yue, K.K.M., Garrod, D.R. and Nishikawa, T. (1995). A Case of Pemphigus Vulgaris Showing Reactivity with Pemphigus Antigens (Dsgl and Dsg3) and Desmocollin. Journal of Investigative Dermatology, 104, 541-544.

Yue, K.K.M., Holton, J.L., Clarke., J.P., Hyam, J.I.M., Hashimoto, T., Chidgey, M.A.J. and Garrod, D.R. (1995). Characterisation of a Desmocollin Isoform (Bovine DSC3) Exclusively Expressed in the Lower Layers of Stratified Epithelia. Journal of Cell Science, 108, 2163-2173.

Legan, P.K., Yue, K.K.M., Chidgey, M.A.J., Holton, J.L., Wilkinson, R.W. and Garrod, D.R. (1994). The Bovine Desmocollin Family: A New Gene and Expression Patterns Reflecting Epithelial Cell Proliferation and Differentiation. Journal of Cell Biology, 126, 507-518.

Full List of Publications