Prof JIA Wei

  • Associate Dean (International Collaboration) of Chinese Medicine; Cheung On Tak Endowed Professor in Chinese Medicine; Chair Professor, Teaching and Research Division; Director, Hong Kong Traditional Chinese Medicine Phenome Research Centre
  • Director of Hong Kong Traditional Chinese Medicine Phenome Research Centre; Adjunct Professor of the Shanghai Jiao Tong University affiliated 6th People's Hospital; Director of the Center for Translational Medicine

Prof. Jia's M.S. and Ph.D. were completed at the University of Missouri-Columbia in the field of radiopharmaceutical science. Previously, he has been a (tenured, full) Professor of the University of Hawaii at Manoa, and Associate Director of the University of Hawaii Cancer Center (a National Cancer Institute designated cancer center). Prof. Jia also served as a (tenured, full) Professor at the University of North Carolina at Greensboro and Co-Director of UNCG Center for Translational Biomedical Research for about 5 years. Prior to his appointment with UNCG, Prof. Jia worked in China for 10 years as Professor and Executive Vice Dean at College of Pharmaceutical Science, Tianjin University, and Professor and Vice Dean for Research, School of Pharmacy, Shanghai Jiao Tong University.

Prof. Jia has 30 years of experience as a scientist in the medical field with a proven track record of building and operating highly successful interdisciplinary research programs, such as translational research centers, clinical -omics platforms, and botanical-based drug development laboratories in collegiate and industrial settings.

His research interest focuses on microbial metabolomics and host-gut microbe metabolic interactions that underlie the development of gastrointestinal diseases and metabolic disorders and the treatment of these conditions using small molecule compounds, natural products, and traditional Chinese medicines. His group currently operates a world-class metabolomics laboratory, to quantitatively determine endogenous small-molecule metabolites and trace elements, supporting translational research in cancer biology, drug discovery, and traditional Chinese medicine.

Selected Publications

Google Scholar Citations: 29,000, H index: 81, March 2022

  • Li MC, Wang SL, Li YT, Zhao ML, Kuang JL, Liang DD, Wang JY, Wei ML, Rajani C, Ma XR, Tang YJ, Ren ZX, Chen TL, Zhao AH, Hu C, Shen CX, Jia WP, Liu P, Zheng XJ, Jia W*. Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice. Nature Communications, in press, 2022.
  • Wang SL, Kuang JL, Zhang HW, Chen WL, Zheng XJ, Wang JY, Huang FJ, Ge K, Li MC, Zhao ML, Rajani C, Zhu JS, Zhao AH*, Jia W*. Bile acid – microbiome interaction promotes gastric carcinogenesis. Advanced Science, doi:10.1002/advs.2200263, 2022.
  • Zheng XJ, Chen TL, Zhao AH, Ning ZC, Kuang JL, Wang SL, You YJ, Bao YQ, Ma XJ, Yu HY, Zhou J, Jiang M, Li MC, Wang JY, Ma XH, Zhou SP, Li YT, Ge K, Rajani C, Xie GX, Hu C, Guo YK, Lu AP*, Jia WP*, Jia W*. Hyocholic acid species as novel biomarkers for metabolic disorders. Nature Communications, 12(1):1-11, 2021. doi: 10.1038/s41467-021-21744-w.
  • Zheng XJ, Chen TL, Jiang RQ, Zhao AH, Wu Q, Kuang JL, Sun DN, Ren ZX, Li MC, Zhao ML, Wang SL, Bao YQ, Li HT, Hu C, Dong B, Li DF, Wu JY, Xia JL, Wang XM, Lan K, Rajani C, Xie GX, Lu AP, Jia WP*, Jiang CT*, Jia W*. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell Metabolism, 33(4):791-803, 2021. doi: 10.1016/j.cmet.2020.11.017.
  • Jia W*, Wei ML, Rajani C, Zheng XJ. Targeting the alternative bile acid synthetic pathway for metabolic diseases. Protein & Cell, 12(5):411-425, 2021. doi: 10.1007/s13238-020-00804-9.
  • Huang FJ, Zheng XJ, Ma XH, Jiang RQ, Zhou WY, Zhou SP, Zhang YJ, Lei S, Wang SL, Kuang JL, Han XL, Wei ML, You YJ, Li MC, Li YT, Liang DD, Liu JJ, Chen TL, Yan C, Wei RM, Rajani C, Shen CX, Xie GX, Bian ZX, Li HK, Zhao AH*, Jia W*. Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism. Nature Communication, 10(1):1-17, 2019. doi: 10.1038/s41467-019-12896-x.
  • Jia W*, Xie GX, Jia WP. Bile acids and microbiome cross-talk and its impact on gastrointestinal inflammation and carcinogenesis. Nature Reviews Gastroenterology and Hepatology, 15(2):111-128, 2018. doi: 10.1038/nrgastro.2017.119.
  • Xie GX, Wang SL, Hang H, Zhao AH, Liu JJ, Ma YM, Lan K, Liu CX, Liu P, Chen TL, Jia W*. Poly-Pharmacokinetic study of a multicomponent herbal medicine in healthy Chinese volunteers. Clinical Pharmacology & Therapeutics, 103(4):692-702, 2018.
  • Chen WL, Wang YY, Zhao AH, Xia L, Xie GX, Su MM, Zhao LJ, Liu JJ, Qu C, Wei RM, Rajani C, Ni Y, Cheng Z, Chen Z, Chen SJ*, Jia W*. Enhanced fructose utilization mediated by SLC2A5 is a unique metabolic feature of acute myeloid leukemia with therapeutic potential. Cancer Cell, 30(5):779-791, 2016. doi: 10.1016/j.ccell.2016.09.006.
  • Chen WL, Wang JH, Zhao AH, Xu X, Wang YH, Chen TL, Li JM, Mi JQ, Zhu YM, Liu YF, Wang YY, Jin J, Huang H, Wu DP, Li Y, Yan XJ, Yan JS, Li JY, Wang S, Huang XJ, Wang BS, Chen Z, Chen SJ*, Jia W*. A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value. Blood, 124(10):1645-1654, 2014. doi: 10.1182/blood-2014-02-554204.
  • Zheng XJ, Zhao AH, Xie GX, Chi Y, Zhao LJ, Li HK, Wang CR, Bao YQ, Jia WP, Luther M, Su MM, Nicholson JK, Jia W*. Melamine-induced renal toxicity is mediated by the gut microbiota. Science Translational Medicine, 5(172):172ra22-172ra22, 2013. doi: 10.1126/scitranslmed.3005114.
  • Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, Pettersson S, Host-Gut Microbiota Metabolic Interactions. Science, 336(6086):1262-1267, 2012. doi: 10.1126/science.1223813.
  • Jia W*, Li H, Zhao L, Nicholson JK. Gut microbiota: a potential new territory for drug targeting. Nature Reviews Drug Discovery, 7(2):123-129, 2008. doi: 10.1038/nrd2505.
  • Chen MJ, Zhao LP, Jia W*. Metabonomic study on the biochemical profiles of a hydrocortisone induced animal model. Journal of Proteome Research, 4(6):2391-23916, 2005.