吕爱平教授

  • 中医药学院院长;黄英豪博士中医药教授;岑尧宽岑碧泉纪念癌症炎症研究中心主任;整合生物信息医学与转化科学研究所所长;香港浸会大学疼痛联合研究中心主任
  • 中医药丶临床药理与关节类及相关新药研发专家
  • aipinglu@hkbu.edu.hk

吕爱平,香港浸会大学中医药学院院长丶讲座教授,香港浸会大学骨与关节疾病转化医学研究所所长,香港浸会大学整合生物信息医学和转化科学研究所所长,中国中医科学院首席研究员。是国家杰出青年基金获得者。是国家自然科学基金委员会医学部谘询委员会委员, 国家药典委员会委员,全国科学技术名词审定委员会中医名词术语委员会副主任委员, 国际标准化组织-TC249 中方Mirror Committee 主席。曾任中国中医科学院临床基础研究所常务副所长(法人代表)丶中国中医研究院基础理论研究所所长丶江西本草天工科技有限公司(中药固体制剂制造技术国家工程研究中心)董事长。

长期从事中医证候分类治疗类风湿关节炎的基础和新药研发工作。曾获卫生部有突出贡献中青年奖和中国标准突出贡献奖。发表学术论文500 馀篇,其中包括Nature Medicine, Biomaterials, Briefings in Bioinformatics, Clinical Pharmacology and Therapeutics, Scientific Reports, Journal of Proteomic Research 等 SCI 收录论文近200 篇。获PCT和国家发明专利60 余项。编写著作30 馀部。先後在Ohio State University丶Lund University丶香港科技大学和香港理工大学做访问学者,多次受邀在国际学术会议上做特邀报告。

精选出版物

  • Li D, Liu J, Guo B, Liang C, Dang L, Lu C, He X, Cheung HY, Xu L, Lu C, He B, Liu B, Shaikh AB, Li F, Wang L, Yang Z, Au DW, Peng S, Zhang Z, Zhang BT, Pan X, Qian A, Shang P, Xiao L, Jiang B, Wong CK, Xu J, Bian Z, Liang Z, Guo DA, Zhu H, Tan W, Lu A, Zhang G. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun. 2016:7:10872.
  • Yao H, Jiang F, Lu A, Zhang G. Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs). Int J Mol Sci. 2016: 17(2). pii: E194.
  • Zhou W, Wang Y, Lu A, Zhang G. Systems Pharmacology in Small Molecular Drug Discovery. Int J Mol Sci. 2016:17(2). pii: E246.
  • Yu Y, Liang C, Lv Q, Li D, Xu X, Liu B, Lu A, Zhang G. Molecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers. Int J Mol Sci. 2016:11;17(3). pii: E358.
  • Wang C, Liu B, Xu X, Zhuang B, Li H, Yin J, Cong M, Xu W,, Lu A. (2016) Toward targeted therapy in chemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine. Oncotarget. [Epub ahead of print]
  • Tan Y, Liu X, Zhou K, He X, Lu C, He B, Niu X, Xiao C, Xu G, Bian Z, Zu X, Zhang G, Zhang W, Lu A. The Potential Biomarkers to Identify the Development of Steatosis in Hyperuricemia. PLoS One 2016:11(2):e0149043.
  • Yu Y, Liang C, Lv Q, Li D, Xu X, Liu B, Lu A, Zhang G. Molecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers. Int J Mol Sci. 2016 Mar 11;17(3).
  • Gong Y, Lin Y, Zhao N, He X, Lu A, Wei W, Jiang M. The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population. Mediators Inflamm. 2016;2016:7089137.
  • Ning Z, Liu Z, Song Z, Zhao S, Dong Y, Zeng H, Shu Y, Lu C, Liu Y, Lu A. A single marker choice strategy in simultaneous characterization and quantification of multiple components by rapid resolution liquid chromatography coupled with triple quadrupole tandem mass spectrometry (RRLC-QqQ-MS). J Pharm Biomed Anal. 2016 Mar 3;124:174-188.
  • Zhang B, Fu Y, Huang C, Zheng C, Wu Z, Zhang W, Yang X, Gong F, Li Y, Chen X, Gao S, Chen X, Li Y, Lu A, Wang Y. New strategy for drug discovery by large-scale association analysis of molecular networks of different species. Sci Rep. 2016 Feb 25;6:21872.
  • Zhou W, Wang Y, Lu A, Zhang G. Systems Pharmacology in Small Molecular Drug Discovery. Int J Mol Sci. 2016 Feb 18;17(2).
  • Tan Y, Liu X, Zhou K, He X, Lu C, He B, Niu X, Xiao C, Xu G, Bian Z, Zu X, Zhang G, Zhang W, Lu A. The Potential Biomarkers to Identify the Development of Steatosis in Hyperuricemia. PLoS One. 2016 Feb 18;11(2):e0149043.  
  • Wang C, Liu B, Xu X, Zhuang B, Li H, Yin J, Cong M, Xu W, Lu A. Toward targeted therapy in hemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine. Oncotarget. 2016 Jan 29. doi: 10.18632/oncotarget.7073. [Epub ahead of print]
  • Jiang M, Zha Q, Zhang C, Lu C, Yan X, Zhu W, Liu W, Tu S, Hou L, Wang C, Zhang W, Liang Q, Fan B, Yu J, Zhang W, Liu X, Yang J, He X, Li L, Niu X, Liu Y, Guo H, He B, Zhang G, Bian Z, Lu A. Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial. Sci Rep. 2015 Apr 15;5:9700.
  • Zhang X, Ng HL, Lu A, Lin C, Zhou L, Lin G, Zhang Y, Yang Z, Zhang H. Drug delivery system targeting advanced hepatocellular carcinoma: Current and future. Nanomedicine. 2016 Jan 7. pii: S1549-9634(16)00005-8. doi: 10.1016/j.nano.2015.12.381. [Epub ahead of print]
  • Li Y, Wang J, Xiao Y, Wang Y, Chen S, Yang Y, Lu A, Zhang S. A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis. J Ethnopharmacol. 2015:175:301-314.
  • Guo J, Qin S, Liang J, Lin T, Si L, Chen X, Chi Z, Cui C, Du N, Fan Y, Gu K, Li F, Li J, Li Y, Liang H, Liu J, Lu M, Lu A, Nan K, Niu X, Pan H, Ren G, Ren X, Shu Y, Song X, Tao M, Wang B, Wei W, Wu D, Wu L, Wu A, Xu X, Zhang J, Zhang X, Zhang Y, Zhu H; written; Chinese Society of Clinical Oncology (CSCO) Melanoma Panel. Chinese Guidelines on the Diagnosis and Treatment of Melanoma (2015 Edition). Ann Transl Med. 2015 Dec;3(21):322.
  • Zhao N, Li J, Li L, Niu XY, Jiang M, He XJ, Bian ZX, Zhang G, Lu A. Molecular network-based analysis of guizhi-shaoyao-zhimu decoction, a TCM herbal formula, for treatment of diabetic peripheral neuropathy. Acta Pharmacol Sin. 2015 Jun;36(6):716-723.
  • Zhang B, Lu C, Bai M, He X, Tan Y, Bian Y, Xiao C, Zhang G, Lu A, Li S. (2015) Tetramethylpyrazine identified by a network pharmacology approach amel iorates methotrexate-induced oxidative organ injury. J Ethnopharmacol.175:638-647.
  • Lin C, Ng HL, Pan W, Chen H, Zhang G, Bian Z, Lu A, Yang Z. Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy. Int J Mol Sci. 2015 Nov 11;16(11):26936-52.
  • Fatima S, Shi X, Lin Z, Chen GQ, Pan XH, Wu JC, Ho JW, Lee NP, Gao H, Zhang G, Lu A, Bian ZX. 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. Mol Oncol. 2016 Feb;10(2):195-212.
  • Jiang F, Liu B, Lu J, Li F, Li D, Liang C, Dang L, Liu J, He B, Badshah SA, Lu C, He X, Guo B, Zhang XB, Tan W, Lu A, Zhang G. Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems. Int J Mol Sci. 2015 Oct 9;16(10):23784-822.
  • Zhang B, Lu C, Bai M, He X, Tan Y, Bian Y, Xiao C, Zhang G, Lu A, Li S. Tetramethylpyrazine identified by a network pharmacology approach ameliorates methotrexate-induced oxidative organ injury. J Ethnopharmacol. 2015 Dec 4;175:638-47.
  • Xu S, Zhang T, Kompella SN, Yan M, Lu A, Wang Y, Shao X, Chi C, Adams DJ, Ding J, Wang C. Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci Rep. 2015 Sep 23;5:14261.
  • Niu X, Lu C, Xiao C, Ge N, Jiang M, Li L, Bian Y, Xu G, Bian Z, Zhang G, Lu A. The Crosstalk of Pathways Involved in Immune Response Maybe the Shared Molecular Basis of Rheumatoid Arthritis and Type 2 Diabetes. PLoS One. 2015:10(8):e0134990.
  • Li Y, Wang J, Xiao Y, Wang Y, Chen S, Yang Y, Lu A, Zhang S. A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis. J Ethnopharmacol. 2015 Dec 4;175:301-14.
  • Li P, Huang C, Fu Y, Wang J, Wu Z, Ru J, Zheng C, Guo Z, Chen X, Zhou W, Zhang W, Li Y, Chen J, Lu A, Wang Y. Large-scale exploration and analysis of drug combinations. Bioinformatics. 2015:31(12):2007-2016.
  • Shi N, Zhong LL, Han X, Ziea TC, Ng B, Bian Z, Lu A. Enhanced evidence-based chinese medicine clinical practice guidelines in Hong Kong: a study protocol for three common diseases. Evid Based Complement Alternat Med. 2015:2015:482706.
  • Chen GQ, Tang CF, Shi XK, Lin CY, Fatima S, Pan XH, Yang DJ, Zhang G, Lu AP, Lin SH, Bian ZX. Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism. Oncotarget. 2015:6(27):24148-24162.
  • Liu J, Dang L, Li D, Liang C, He X, Wu H, Qian A, Yang Z, Au DW, Chiang MW, Zhang BT, Han Q, Yue KK, Zhang H, Lv C, Pan X, Xu J, Bian Z, Shang P, Tan W, Liang Z, Guo B, Lu A, Zhang G. A delivery system specifically 2015: 52:148-160.
  • Liang C, Guo B, Wu H, Shao N, Li D, Liu J, Dang L, Wang C, Li H, Li S, Lau WK, Cao Y, Yang Z, Lu C, He X, Au DW, Pan X, Zhang BT, Lu C, Zhang H, Yue K, Qian A, Shang P, Xu J, Xiao L, Bian Z, Tan W, Liang Z, He F, Zhang L, Lu A, Zhang G. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat Med 2015: 21(3):288-294.
  • Li J, Liu Z, Guo M, Xu K, Jiang M, Lu A, Gao X. Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis. Evid Based Complement Alternat Med. 2015:2015:897914.
  • Wang Y, Guo Z, Chen X, Zhang W, Lu A, Wang Y. Multi-scale modeling of cell survival and death mediated by the p53 network: a systems pharmacology framework. Mol Biosyst. 2015 Nov;11(11):3011-21.
  • Fan L, Gong J, Fu W, Chen Z, Xu N, Liu J, Lu A, Li Z, Wu T, Ou A, Xie H. Gender-Related Differences in Outcomes on Acupuncture and Moxibustion Treatment Among Depression Patients. J Altern Complement Med. 2015 Nov;21(11):673-80.
  • Deng Y, Yang M, Xu F, Zhang Q, Zhao Q, Yu H, Li D, Zhang G, Lu A, Cho K, Teng F, Wu P, Wang L, Wu W, Liu X, Guo DA, Jiang B. Combined Salvianolic Acid B and Ginsenoside Rg1 Exerts Cardioprotection against Ischemia/Reperfusion Injury in Rats. PLoS One. 2015 Aug 17;10(8):e0135435.
  • Niu X, Lu C, Xiao C, Ge N, Jiang M, Li L, Bian Y, Xu G, Bian Z, Zhang G, Lu A. The Crosstalk of Pathways Involved in Immune Response Maybe the Shared Molecular Basis of Rheumatoid Arthritis and Type 2 Diabetes. PLoS One. 2015 Aug 7;10(8):e0134990.
  • Jiang F, Liu B, Lu J, Li F, Li D, Liang C, Dang L, Liu J, He B, Badshah SA, Lu C, He X, Guo B, Zhang XB, Tan W, Lu A, Zhang G. ) Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems. Int J Mol Sci. 2015:16(10):23784-23822.
  • Li J, Liu Z, Guo M, Xu K, Jiang M, Lu A, Gao X. Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis. Evid Based Complement Alternat Med. 2015;2015:897914.
  • Lu A, Xue C, Bian Z, Cho WC. TCM Zheng Classification and Clinical Trials 2014. Evid Based Complement Alternat Med. 2015;2015:538989.
  • Liu J, Dang L, Li D, Liang C, He X, Wu H, Qian A, Yang Z, Au DW, Chiang MW, Zhang BT, Han Q, Yue KK, Zhang H, Lv C, Pan X, Xu J, Bian Z, Shang P, Tan W, Liang Z, Guo B, Lu A, Zhang G. A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts. Biomaterials. 2015 Jun;52:148-60.
  • Shi N, Zhong LL, Han X, Ziea TC, Ng B, Bian Z, Lu A. Enhanced evidence-based Chinese medicine clinical practice guidelines in Hong Kong: a study protocol for three common diseases. Evid Based Complement Alternat Med. 2015;2015:482706.
  • Gong Y, Liu L, He X, Zhao H, Yang J, Li L, Lu A, Lin Y, Jiang M. The th17/treg immune balance in ulcerative colitis patients with two different chinese syndromes: dampness-heat in large intestine and spleen and kidney yang deficiency syndrome. Evid Based Complement Alternat Med. 2015;2015:264317.
  • Liang C, Li D, Zhang G, Li H, Shao N, Liang Z, Zhang L, Lu A, Zhang G. Comparison of the methods for generating single-stranded DNA in SELEX. Analyst. 2015 May 21;140(10):3439-44.
  • Kwan HY, Niu X, Dai W, Tong T, Chao X, Su T, Chan CL, Lee KC, Fu X, Yi H, Yu H, Li T, Tse AK, Fong WF, Pan SY, Lu A, Yu ZL. Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers. Sci Rep. 2015 Mar 13;5:9114
  • He YX, Liu J, Guo B, Wang YX, Pan X, Li D, Tang T, Chen Y, Peng S, Bian Z, Liang Z, Zhang BT, Lu A, Zhang G. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. Sci Rep. 2015 Mar 9;5:8856.
  • Du Z, Liu Z, Ning Z, Liu Y, Song Z, Wang C, Lu A. Prospects of boswellic acids as potential pharmaceutics. Planta Med. 2015 Mar;81(4):259-71.
  • Jia W, Lu A, Chan K, Gustafsson MG, Liu P. Translational research in complementary and alternative medicine 2014. Evid Based Complement Alternat Med. 2015;2015:427508.
  • Li P, Huang C, Fu Y, Wang J, Wu Z, Ru J, Zheng C, Guo Z, Chen X, Zhou W, Zhang W, Li Y, Chen J, Lu A, Wang Y. Large-scale exploration and analysis of drug combinations. Bioinformatics. 2015 Jun 15;31(12):2007-16.

*corresponding author

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