杨传杉博士

  • 教学科研部研究助理教授
  • 神经退行性疾病;细胞自噬;中草药化合物治疗神经退行的药物研发
  • yangchb@hkbu.edu.hk

杨传彬博士於2007年在皖西学院取得理学学士学位,2010年在南开大学取得理学硕士学位。2014年在香港大学李嘉诚医学院中医药学院取得博士学位後,其於2015年加入香港浸会大学中医药学院任高级研究助理并接受博士後训练,并於2017年10月担任研究助理教授。杨博士的研究兴趣集中在:1)治疗神经退行性疾病的中药研发; 2)自噬通路的失调阿尔茨海默病和帕金森病发生发展中的作用; 3)自噬溶酶体通路的调节机制。


 

精选出版物

Selected publications:

1. Yang, C., Cai, CZ, Song JX, Tan, JQ; Durairajan, SSK, Iyaswamy A, Wu, MY, Chen, LL, Yue, ZY, LI, M., Lu, JH. NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models. Autophagy. 2017;13(12):2028-2040.

2. Yang, C., Zhao, J., Cheng, Y., Le, X. C., Rong, J.. N-Propargyl caffeate amide (PACA) potentiates nerve growth factor (NGF)-induced neurite outgrowth and attenuates 6-Hydroxydopamine (6-OHDA)-induced toxicity by activating the Nrf2/HO-1 pathway. ACS Chemical Neuroscience, 2015; 6(9), 1560-1569.

3. Yang, C. , Pei, W. J., Zhao, J., Cheng, Y. Y., Zheng, X. H., Rong, J. H. Bornyl caffeate induces apoptosis in human breast cancer MCF-7 cells via the ROS-and JNK-mediated pathways. Acta Pharmacologica Sinica, 2014; 35(1), 113-123.

4. Cheng Y#, Yang C#, Luo D, Li X, Le XC, Rong J. N-Propargyl Caffeamide Skews Macrophages Towards a Resolving M2-Like Phenotype Against Myocardial Ischemic Injury via Activating Nrf2/HO-1 Pathway and Inhibiting NF-ĸB Pathway. Cell Physiol Biochem. 2018;47(6):2544-2557.

5. Yang, C., Zhao, J., Pei, W., Zheng, X., Rong, J. Biochemical mechanisms of bornyl caffeate induced cytotoxicity in rat pheochromocytoma PC12 cells. Chemico-Biological Interactions, 2014; 219, 133-142.

6. Yang, C., Zhao, J., Cheng, Y., Li, X., Rong, J. Bioactivity-guided fractionation identifies amygdalin as a potent neurotrophic agent from herbal medicine Semen Persicae extract. BioMed Research International, Biomed Res Int. 2014;2014:306857. doi: 10.1155/2014/306857

7. Yang C, Cheng Y, Zhao J, Rong J. Releasing Nrf2 to promote neurite outgrowth. Neural Regeneration Research, 2015;10(12):1934-1935.

8. Yang, C., Li, X., & Rong, J. Amygdalin isolated from Semen Persicae (Tao Ren) extracts induces the expression of follistatin in HepG2 and C2C12 cell lines. Chinese Medicine, 2014; 9(1), 1-8.

9. Yang, C., Huang, S., Wang, X.. Yang, C., Huang, S., Wang, X., Gu, Y. Emerging Roles of CCCH-Type Zinc Finger Proteins in Destabilizing mRNA Encoding Inflammatory Factors and Regulating Immune Responses. Critical Reviews™ in Eukaryotic Gene Expression, 2015;25(1):77-89.

10. Chen LL, Wang YB, Song JX, Deng WK, Lu JH, Ma LL, Yang C., Li M, Xue Y. Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy. Autophagy, 2017;13(11):1969-1980.

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