锺丽丹博士

  • 教学科研部助理教授
  • 专业研究范围:中医及结合医学治疗消化病丶妇女疾病丶风湿免疫病的临床研究丶中医及中西医结合循证医学及流行病学研究
  • ldzhong@hkbu.edu.hk

锺丽丹博士2002年和2007年毕业於上海中医药大学获医学学士学位及中医临床硕士学位,研究方向为中医及中西医结合治疗自身免疫性疾病临床研究,2012年毕业於香港大学李嘉诚医学院,获研究博士学位,研究方向为妇科中医及结合医学的临床研究。之後加入香港浸会大学中医药学院临床部,主要从事中医药治疗消化丶免疫及妇科疾病的临床研究以及中医药临床规范化研究。2002年起任职上海中医药大学附属龙华医院,从事教学丶临床与科研工作,师从全国名老中医陈湘君教授,2011年加入国家中医药管理局全国名老中医专家陈湘君传承工作室,研究课题“扶正法为主治疗轻中活动度系统性红斑狼疮临床与机制研究”荣获上海市中医药科技进步一等奖。2018年研究课题“麻子仁丸治疗功能性便秘关键问题研究”获得中医药国际贡献奖—科技进步奖二等奖。曾任加州大学洛杉矶分校东西方医学中心访问学者,哈佛大学医学院麻省总院访问学者,多伦多大学结合医学中心访问教授等。先後发表国际期刊学术论文六十馀篇,编写专著十部,主持或参与临床科研课题二十馀项。

具体资讯可以浏览香港中医药临床研究中心网页 (https://cmcs.hkbu.edu.hk/ueditor/php/upload/file/20190829/1567041243182658.pdf)

对上述课题有兴趣之准研究生,博士後研究员和研究助理可电邮至锺博士。  

 

 

精选出版物

  1. Zhong LLD, Yan PJ, Lam WC, Yao L, Bian ZX. Coriolus versicolor and Ganoderma lucidum Related Natural Products as An Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2019 Jul 3;10:703. doi: 10.3389/fphar.2019.00703. eCollection 2019.
  2. Pun J, Chor W, Zhong LLD*. Delivery of patient-centered care in complementary medicine: Insights and evidence from the Chinese medical practitioners and patients in primary care consultations in Hong Kong. Complementary Therapies in Medicine. June, 2019.
  3. Dai L, Zhong LLD (Co-first authors) , Kun W, Yang Z, Lam WC, Cheng CW, Bian ZX. An External CAM Therapy (Tian Jiu) versus Placebo in Treatment of Allergic Rhinitis: A Pilot Single-Blinded, Three-Arm, Randomized Controlled Study. Evidence-Based Complementary and Alternative Medicine, Volume 2019, Article ID 6369754    
  4. Lam WC, Zhong LLD, Liu YQ, Shi NN, Ng Bacon, Ziea Eric, Bian ZX, Lu AP. Hong Kong Chinese Medicine Clinical Practice Guideline for Cancer Palliative Care - Pain, Constipation and Insomnia. eCAM. 2019: 1038206. doi: 10.1155/2019/1038206
  5. Dai L, Cheng CW, Tian R, Zhong LLD, Li YP, Lyu AP, Chan AW, Shang HC, Bian ZX. Standard Protocol Items for Clinical Trials with Traditional Chinese Medicine 2018: Recommendations, Explanation and Elaboration (SPIRIT-TCM Extension 2018). Chin J Integr Med. 2018 Nov. doi: 10.1007/s11655-018-2999-x. [Epub ahead of print]
  6. Hu ZC, Ge LD, Liu T, Zhong LLD*. How to focus on the safety assessment of herb-drug interaction in real world studies. Chinese Journal of Evidence-based Medicine, 2018, 18(11):1158-1162.
  7. Zhong LLD, Cheng CW, Kun W, Dai L, Hu DD, Ning ZW, Xiao HT, Lin CY, Zhao L, Huang T, Tian K, Chan KH, Lam TY, Chen XR, Wong CT, Li M, Lu AP, Wu JC, Bian ZX. Chinese herbal medicine (MaZiRenWan) for Functional Constipation: A Three-arm, Randomized, Controlled Trial. Clinical Gastroenterology and Hepatology 2018 Apr 12. pii: S1542-3565(18)30341-0. doi: 10.1016/j.cgh.2018.04.005.
  8. Cheng CW, Zhang L, Zhao C, Zhong LLD, Shi LJ, Dai L, Zheng R, Chen J, Li G, Zhai JB, Kun W, Lu AP, Shang HC, Bian ZX. Whether Syndrome Differentiation Affects Treatment Result: Study Protocol of MaZiRenWan for Functional Constipation in A Randomized Controlled Trial. Chin J Integr Med. 2018 Aug 14. doi: 10.1007/s11655-018-2848-y. [Epub ahead of print]
  9. Huang T, Ning ZW, Hu DD, Zhang M, Zhao L, Lin CY, Zhong LLD, Yang ZJ, Xu HX, Bian ZX.  Uncovering the Mechanisms of Chinese Herbal Medicine (MaZiRenWan) for Fonctional Constipation by Focused Network Pharmacology Approach. Frontiers in Pharmacology March 2018, 9:270
  10. Huang T, Zhong LLD, Lin, CY, Zhao L, Ning ZW, Hu DD, Zhang M, Tian K, Cheng CW, Bian ZX. Approaches in studying the pharmacology of Chinese Medicine formulas: bottom-up, top-down—and meeting in the middle. Chinese Medicine, 2018, 13:15.
  11. Hu DD, Zhong LLD, Kun W, Mu HX, Lin CY, Zhao L, Dai L, Huang T, Bian ZX. Evaluation of the Pharmacokinetics and Renal Excretion of Ma-Zi-Ren-Wan in Health Subjects. World J Tradit Chin Med. 2017; 3 (2):8-15.
  12. Mi H, Zhong LLD, Huang T, Lin CY, Zhao L, Hu DD, Xiao HT, Bian ZX, Liu FB. Chinese Herbal Medicine for Ulcerative Colitis: A Systematic Review Protocol. World J Tradit Chin Med. 2017; 3(2):16-19.
  13. Liu M, Zhang C, Zha Q, Yang W, Yuwen Y, Zhong LLD, Bian ZX, Han XJ, Lu AP. A national survey of Chinese medicine doctors and clinical practice guidelines in China. BMC Complement Altern Med. 2017 Sep 6;17(1):451.
  14. Dai L, Lu A, Zhong LLD*, Zheng G, Bian Z. Chinese Herbal Medicine for Hyperlipidaemia: a Review Based on Data Mining from 1990 to 2016. Curr Vasc Pharmacol. 2017 Jul 13. doi: 10.2174/1570161115666170713163127.
  15. Huang T, Mi H, Lin CY, Zhao L, Zhong LLD, Liu FB, Zhang G, Lu AP, Bian ZX. MOST: most-similar ligand based approach to target prediction. BMC Bioinformatics. 2017 Mar 11;18(1):165. doi: 10.1186/s12859-017-1586-z.
  16. Liu M, Zhang C, Zha Q, Yang W, Yuwen Y, Zhong LLD, Bian Z, Han X, Lu A. Attitudes to personalized versus standardized practice in traditional Chinese medicine: a national cross-sectional survey of practitioners in China. Lancet. 2016, 288, Suppl 1:S59.
  17. Zhong LLD, Kun W, Lam TF, Zhang SP, Yang JJ, Ziea TC, Ng B, Bian ZX. The combination effects of body acupuncture and auricular acupressure compared to sham acupuncture for body weight control: study protocol for a randomized controlled trial. Trials, 2016:17(1):346.
  18. Zhong LLD, Kun W, Shi NN, Ziea TC, Ng B, Gao Y, Bian ZX, Lu AP*. Evidence-based Chinese Medicine Clinical Practice Guideline for Stroke in Hong Kong. J Tradit Chin Med. (Accepted)
  19. Dai L, Zhong LLD (Co-first author), Cao Y, Chen W, Cheng Y, Lin XF, Bian ZX, Lu AP*. Efficacy and safety of Yirui capsule in patients with hyperlipidemia: study protocol for a multicenter, randomized, double-blind, placebo-controlled trial. Trials. 2016,17(1):291.
  20. Kun W, Zhong LLD, Dai L, Cheng CW, Lu AP, Bian ZX. Tian Jiu therapy for allergic rhinitis: study protocol for a randomized controlled trial. Trials. 2016; 17(1):248. doi: 10.1186/s13063-016-1374-5.
  21. Zhong LLD, Zheng G, Ge LD, Lin CY, Huang T, Zhao L, Lu C, Lu AP, Bian ZX. Chinese herbal medicine for constipation: Zheng-based associations among herbs, formula, proprietary, and herb-drug interactions. Chinese Medicine. 2016 Jun 23;11:28. doi: 10.1186/s13020-016-0099-4.
  22. Liu T, Wang N, Zhang L, Zhong LLD*. Chinese herbal medicine for functional abdominal syndrome: from clinical findings to basic understandings. Evidence-based complementary and alternative medicine. 2016;2016:8652523. doi: 10.1155/2016/8652523.
  23. Wang FY, Zhong LLD (Co-first author), Kang N, Dai L, Lv L, Bian LQ, Chen T, Zhang BH, Bian ZX, Wang XG, Zhu EL, Tang XD. Chinese herbal formula for postprandial distress syndrome: study protocol of a double-blinded, randomized, placebo-controlled trial. European Journal of Integrative Medicine. Available online 17 March, 2016. doi:10.1016/j.eujim.2016.03.010.
  24. Zhong LLD, Kun W, Cheng CW, Zhao L, Lin CY, Huang T, Bian ZX. Tolerability, exposure and pharmacokinetics in healthy subjects of a Chinese herbal medicine MaZiRenWan (MZRW): study protocol of a randomized open-labelled, three-arm phase 0/1 clinical trial. European Journal of Integrative Medicine. Available online 15 March, 2016. doi:10.1016/j.eujim.2016.03.008.
  25. Zhong LLD, Shi NN, Dai L, Ziea TC, Ng B, Tang XD, Bian ZX, Lu AP. Evidence-Based Chinese Medicine Clinical Guideline for Stomach Pain in Hong Kong. Chinese Journal of Integrative Medicine. 2016 Jun 23.
  26. Lu L, Zhang XG, Zhong LLD, Chen ZX, Li Y, Zheng GQ, Bian ZX. Acupuncture for neurogenesis in experimental ischemic stroke: a systematic review and meta-analysis. Sci Rep. 2016 Jan 20;6:19521.
  27. Zhong LLD, Bian ZX. Review of therapeutic evaluation methods of Chinese Medicine treating chronic constipation [Chinese]. J Tradit Chin Med. 2015; 56(23): 2010-2012.
  28. Zhong LLD, Cheng CW, Bian ZX. Comment on efficacy evaluation methods of Chinese Medicine in treating diarrhea of tumor patients after radiotherapy and chemotherapy [Chinese]. J Tradit Chin Med. 2015; 56(21): 1831-1835.
  29. Hu DD, Han QB, Zhong LLD, Li YH, Lin CY, Ho HM, Zhang M, Lin SH, Zhao L, Huang T, Mi H, Tan HS, Xu HX, Bian ZX. Simultaneous determination of ten compounds in rat plasma by UPLC-MS/MS: Application in the pharmacokinetic study of Ma-Zi-Ren-Wan. Journal of Chromatography B. 2015;1000:136-46
  30. Fu SF, Kun W, Zeng XX, Zhang L, Cheng CW, Zhong LLD, Lin J, Zhang BL, Wang YY, Shang HC, Bian ZX*. Urgent Need to improve the quality of case report in traditional Chinese medicine: assessment of reporting quality of 3417 cases. Chinese Journal of Integrative Medicine. 2016, Jan 23.
  31. Fu SF, Cheng CW, Zhang L, Zhong LLD, Kun W, Lin J, Zhang BL, Wang YY, Shang HC, Bian ZX*. Consensus-based Recommendations for case report in Chinese Medicine (CARC). Chinese Journal of Integrative Medicine. 2016, 22 (1):73-9.
  32. Song TJ, Leng HF, Zhong LLD, Wu TX, Moher D, Bian ZX. CONSORT in China: A decade development and future direction. Trials. 2015; 16(1):243.
  33. Shi NN, Zhong LLD (Co-first author), Han XJ, Ziea Eric, Ng Bacon, Bian ZX, and Lu AP. Enhanced Evidence-Based Chinese Medicine Clinical Practice Guidelines in Hong Kong: A Study Protocol for Three Common Diseases. Evid Based Complement Alternat Med. 2015;2015:482706.
  34. Xiao HT, Zhong LLD, Lin ZS, Bian ZX.  Traditional Chinese Medicine Formulas for Irritable Bowel Syndrome: from ancient wisdoms to scientific understandings. Am J Chin Med. 2015;43(1):1-23.
  35. Yuwen Y, Shi NN, Han XJ, Gao Y, Xu JL, Liu DS, Ng B, Tsui D, Zhong LLD, Ziea E, Bian ZX, Lu AP. Appraisal of clinical practice guidelines for ischemic stroke management in Chinese medicine with appraisal of guidelines for research and evaluation instrument: A systematic review. Chin J Integr Med. 2015;21(9):707-15.
  36. Wang D, Lu CY, Teng LS, Guo ZH, Meng QF, Liu Y, Zhong LLD, Wang W, Xie J, Zhang ZJ. Therapeutic effects of Chinese herbal medicine against neuroendocrinological diseases especially related to hypothalamus-pituitary-adrenal and hypothalamus-pituitary-gonadal axis. Pak J Pharm Sci. 2014 May; 27(3 Suppl):741-54.
  37. Yu WY, Han XJ, Shi NN, Wang LY, Liao X, Zhong LLD, Bian ZX, Lu AP Appraisal of clinical practice guidelines for the management of rheumatoid arthritis in traditional Chinese medicine using the AGREE II instrument: A systematic review. European Journal of Integrative Medicine 2014 April; (2): 176-185.
  38. Zhong LLD, Hu DD, Han QB, Xu HX, Bian ZX. Efficacy-driven quality control platform for Chinese herbal medicine. Pharmaceutica Analytica Acta. 5:291. doi:10.4172/2153-2435.1000291
  39. Zhong LLD, Cheng CW, Wu TX, Li YP, Shang HC, Zhang BL, Tang XD, Lu AP, Bian ZX. Increasing Protocol Design is the Cornerstone for Overall Improvement of Clinical Trials. Chin J Evid-based Med 2013; 13(12): 1500
  40. Zhong LLD, Cheng CW, Wu TX, Li YP, Shang HC, Zhang BL, Tang XD, Lu AP, Bian ZX. SPIRIT 2013 Statement: Defining standard protocol items for clinical trials [Chinese]. Chin J Evid-based Med 2013; 12: 1501-1507
  41. Zhong LLD, Cheng CW, Chan Y, Chan KH, Lam TW, Chen XR, Wong CT, Wu JC, Bian ZX. Chinese herbal medicine (Ma Zi Ren Wan) for functional constipation: study protocol for a prospective, double-blinded, double-dummy, randomized controlled trial. Trials. 2013 Nov 4; 14(1):366.
  42. Zhong LLD, Bian ZX, Gu JH, Zhou X, Tian Y, Mao JC, Chen XJ. Chinese Herbal Medicine (Zi Shen Qing) for Mild-to-Moderate Systematic Lupus Erythematosus: A Pilot Prospective, Single-Blinded, Randomized Controlled Study. Evid Based Complement Alternat Med. 2013: 327245.
  43. Zhong LLD, Tong Yao, Grace WK Tang, et al. A randomized double-blinded controlled trial of a Chinese herbal formula (Er-Xian Decoction) for menopausal symptoms in Hong Kong perimenopausal women. Menopause. 2013 Jul;20(7):767-76.
  44. Zhong LLD, Chen HY, Cho WCS, Meng XM, Tong Y. The Efficacy of Chinese Herbal Medicine as an Adjunctive Therapy for Colorectal Cancer: a Systematic Review and Meta-analysis Complement Ther Med. 2012; 20(4): 240-252.
  45. Yu X, Tong Y, Hin-Fai Kwok F, Cho-Wing Sze S, Zhong LLD, Bik-San Lau C, et al. Anti-angiogenic activity of Erxian Decoction, a traditional Chinese herbal formula, in zebrafish. Biol Pharm Bull. 2012;35(12):2119-27.
  46. Hu YM, Wang YT, Sze SCW, Tsang KW, Wong HK, Liu Q, Zhong LLD, Tong Y. Identification of the Major Chemical Constituents and Their Metabolites in Rat Plasma and Various Organs after Oral Administration of Effective Erxian Decoction (EXD) Fraction by Liquid Chromatography-mass Spectrometry. Biomed chromatogr. 2010 May; 24 (5): 479-489.
  47. Zhong LLD. Dr. Chen Xiangjun’s Experience in Using Pair of Drugs to Treat Rheumatic Diseases. J Tradit Chin Med, 2005,25(4):282-289.
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