于媛媛博士

于媛媛博士於2015年在香港大学医学院取得生物化学博士学位。毕业後即加入香港浸会大学中医药学院接受博士後训练,并於2019年开始担任研究助理教授职位。于媛媛博士的研究兴趣集中在1)核酸适配体筛选方法的优化;2)核酸适配体的转化医学研究及药物发现;3)核酸适配体的结构生物学研究。

精选出版物

  1. Li F, Lu J, Liu J, Liang C, Wang M, Wang L, Li D, Yao H, Zhang Q, Wen J, Zhang ZK, Li J, Lv Q, He X, Guo B, Guan D, Yu Y, Dang L, Wu X, Li Y, Chen G, Jiang F, Sun S, Zhang BT, Lu A, Zhang G. (2017) A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer. Nat Commun 8(1):1390
  2. Zhuo Z, Yu Y, Wang M, Li J, Zhang Z, Liu J, Wu X, Lu A, Zhang G & Zhang BT. (2017) Recent advances in SELEX technology and aptamer applications in biomedicine. Int J Mol Sci 18(10). (co-first author)
  3. Wu X, Shaikh AB, Yu Y, Li Y, Ni S, Lu A & Zhang G. (2017) Potential diagnostic and therapeutic applications of oligonucleotide aptamers in breast cancer. Int J Mol Sci 18(9). (co-first author)
  4. Zhang Q, Lv H, Wang L, Chen M, Li F, Liang C, Yu Y, Jiang F, Lu A, Zhang G. (2016) Recent Methods for Purification and Structure Determination of Oligonucleotides. Int J Mol Sci 17(12).
  5. Lv Q, Meng Z, Yu Y, Jiang F, Guan D, Liang C, Zhou J, Lu A & Zhang G. (2016) Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer. Int J Mol Sci 17(12). (co-first author)
  6. Chen M, Yu Y, Jiang F, Zhou J, Li Y, Liang C, Dang L, Lu A, Zhang G. (2016) Development of Cell-SELEX Technology and Its Application in Cancer Diagnosis and Therapy. Int J Mol Sci 17(12). (co-first author)
  7. Wang M, Yu Y, Liang C, Lu A, Zhang G. (2016) Recent Advances in Developing Small Molecules Targeting Nucleic Acid. Int J Mol Sci 17(6)
  8. Yu Y, Liang C., Lv Q., Li D., Xu X., Liu B., Lu A. & Zhang G. (2016) Molecular selection, modification and development of therapeutic oligonucleotide aptamers. Int J Mol Sci 17(3):358.
  9. Yu Y, Li X, He J, Zhang M, Li H, Wei D & Song Y. (2012) Appendant structure plays an important role in amyloidogenic cystatin dimerization prior to domain swapping, J Biomol Struct Dyn 30, 102-112.
  10. Shen M, Guan J, Xu L, Yu Y, He J, Jones GW & Song Y. (2012) Steered molecular dynamics simulations on the binding of the appendant structure and helix-beta2 in domain-swapped human cystatin C dimer, J Biomol Struct Dyn 30, 652-661.
  11. Yu Y, Wang Y, He J, Liu Y, Li H, Zhang H & Song Y. (2010) Structural and dynamic properties of a new amyloidogenic chicken cystatin mutant I108T, J Biomol Struct Dyn 27, 641-649.

 

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