王凯亮博士

王凯亮博士分别于2009年和2013年在香港大学获得生物化学学士学位及博士学位,毕业后曾在香港大学生物医学学院和香港中文大学从事博士后研究,于2016年加入香港浸会大学中医药学院担任研究助理教授,2020年晋升为助理教授。

王博士致力于探索细胞外基质及膜型基质金属蛋白酶在发育过程中的调节机制,并揭示了MT1-MMP在多种信号通路调节中的主导作用。他还集中研究干细胞在发育过程和疾病中的重要性,分别在Developmental Cell Nature CommunicationsThe EMBO Journal MicrobiomeCell Death & Disease等国际著名的核心期刊上发表了研究论文和评论文章。

 

主要研究:

1. 细胞外基质在发育过程和疾病中的调节机制

2. 干细胞自我更新和分化在发育和疾病中的重要性

3. 中药化合物在代谢疾病治疗中的作用

***诚挚邀请研究生,博士后研究员和研究助理加入我们的团队。有关职位的查询,请联系王博士(电子邮件:xavierwong@hkbu.edu.hk)

精选出版物

  1. Qin HY, Wong HLX, Zang KH, Li X, Bian Z (2019) Enterochromaffin cell hyperplasia in the gut: Factors, mechanism and therapeutic clues, Life Sciences, 116886, [Impact factor: 3.448 in 2019]
  2. Fatima S, Hu X, Huang C, Zhang W, Cai J, Huang M, Gong RH, Chen M, Ho AHM, Su T, Wong HLX, Bian Z, Kwan HY (2019) High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner Cell Death & Disease 10, 711, [Impact factor: 5.638 in 2019]
  3. Kwan HY, Liu B, Huang C, Fatima S, Su T, Ho AHM, Han Q, Hu X, Gong RH, Chen M, Wong HLX, Bian Z (2019) Signal transducer and activator of transcription-3 (STAT-3) drives the high fat diet-associated prostate cancer growth. Cell Death & Disease 10, 637, [Impact factor: 5.638 in 2019]
  4. Chow CFW, Che S, Qin HY, Kwan HY, Bian Z, Wong HLX (2019) From psychology to physicality: How Nerve Growth Factor transduces early life stress into gastrointestinal motility disorders later in life. Cell Cycle 18, 1824-1829 [Impact factor:3.304 in 2019]
  5. Wong HLX, Qin H, Tsang SW, Zuo X, Che S, Chow CFW, Li X. Xiao HT, Zhao L, Huang T, Lin CY, Kwan HY, Yang T, Longo FM, Lyu A, Bian Z (2019) Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Communications 10(1):1745 [5-year Impact factor:13.811 in 2019]
  6. Fatima S, Hu X, Gong RH, Huang C, Chen M, Wong HLX, Bian Z, Kwan HY (2019) Palmitic acid is an intracellular signaling molecule involved in disease development. Cellular and Molecular Life Science [Impact factor: 6.721 in 2018]
  7. Zhao L, Huang Y, Lu L, Yang W, Huang T, Lin Z, Lin CY, Kwan HY, Wong HLX, Chen Y, Sun S, Xie X, Fang X, Yang H, Wang J, Zhu L, Bian Z (2018) Saturated long-chain fatty acid-producing bacteria contributes to enhanced colonic motility in rats. Microbiome 2018;6(1):107. [Impact factor:10.465 in 2019]
  8. Wong HLX, Jin G, Zhang S, Cao R, Cao Y, Zhou Z (2016) MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis. Nature Communications 7:10824 [Impact factor: 12.124 in 2016]
  9. Chan KM*, Wong HLX* (*co-first), Jin G, Liu B, Cao R, Cao Y, Lehtl K, Tryggvason K and Zhou Z (2012). MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling in calvarial osteogenesis. Developmental Cell, 22(6); 1176-1190 [5-year Impact factor: 14.202 in 2012]
    • [recommended in F1000 Prime, F1000 factor 8.0]
  10. Wong HLX, Cao R, Chan KM, Jin G, Cao Y, Zhou Z (2012). When MT1-MMP Meets ADAMs. Cell Cycle, 11 [Impact factor:5.243 in 2012]
  11. Wong HLX, Zhou Z (2012) The Functional Crosstalk between MT1-MMP and ADAMs (2012) Biochemistry & Analytical Biochemistry (invited editorial)
  12. Jin G, Zhang F, Chan KM, Wong HLX, Liu B, Cheah KSE, Liu X, Mauch C, Liu D, Zhou Z (2011). MT1-MMP cleaves Dll1 to negatively regulate Notch signaling to maintain normal B-cell development. EMBO J., 30: 2281-2293 [Impact factor:9.205 in 2011]
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