周立敏博士

周立敏博士1993年获渖阳药科大学药学学士学位,1999年获日本千叶大学制剂工学硕士学位,2008年获香港中文大学药剂学院生物药剂学博士学位。周博士的研究领域主要是药物缓丶控释制剂的研发丶中药活性成分的生物药剂学及药物代谢动力学研究以及中西药的相互作用。2016年9月获聘为持续及专业教育部一级讲师,现从事中药药剂学丶药事管理学等相关学科的教学工作。

精选出版物

Book Chapter:

  1. Zhong Zuo, Li Zhang, Limin Zhou. Intestinal absorption and disposition of Green Tea catechins: The first barrier for Green Tea catechins entering the body. In: TEA in Health and Disease Prevention. Edited by Victor R. Preedy. Publisher: Elsevier Inc. 2012, pp. 399-412

Journal papers:

  1. Wang Y, Li M, Qian S, Zhang Q, Zhou L, Zuo Z, Lee B, Toh M, Ho T. Zolpidem Mucoadhesive Formulations for Intranasal Delivery: Characterization, In Vitro Permeability, Pharmacokinetics, and Nasal Ciliotoxicity in Rats. J Pharm Sci. 105(9):2840-2847 (2016).
  2. Zhang X, Ng HL, Lu A, Lin C, Zhou L, Lin G, Zhang Y, Yang Z, Zhang H. Drug delivery system targeting advanced hepatocellular carcinoma: Current and future. Nanomedicine. 12(4):853-869 (2016).
  3. Fong SY, Zhang Y, Wong YC, Zhou L, Han Q, Zuo Z. Identification and sitidispoon of novel mono-hydroxyl mefenamic acid and their potentially toxic 1-O-acyl-glucuronides in vivo. Biopharm Drug Dispos. 36(8): 529-551 (2015).
  4. Zhang Z, Ge B, Zhou L, Lam TN, Zuo Z. Induction of liver cytochrome P450s by Danshen-Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin. J Ethnopharmacol. 154(3):672-86 (2014).
  5. Zhou L, Wang S, Zhang Z, San Lau B, Pui Fung K, Chung Leung P, Zuo Z. Pharmacokinetic and pharmacodynamic interaction of Danshen-Gegen extract with warfarin and aspirin. J Ethnopharmacol. 143(2): 48-55 (2012).
  6. Li C, Zhang L, Zhou L, Wo SK, Lin G, Zuo Z. Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. AAPS J. 14(1): 3-34 (2012).
  7. Fong YK, Li CR, Wo SK, Wang S, Zhou L, Zhang L, Lin G, Zuo Z. In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of Baicalein. J Ethnopharmacol. 141(2): 742-53 (2012).
  8. Zuo Z, Wo SK, Lo CM, Zhou L, Cheng G, You JH. Simultaneous measurement of S-warfarin, R-warfarin, S-7-hydroxywarfarin and R-7-hydroxywarfarin in human plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 52 (2): 305-310 (2010).
  9. Zhou L, Chow M, Zuo Z. Effect of sodium caprate on the intestinal absorption and oral bioavailabilities of danshensu and salvianolic acid B, the major hydrophilic active components in Saliva miltiorrhiza Bge. Int. J. Pharm. 379 (1): 109-118 (2009).
  10. Li C, Zhou L, Lin G, Zuo Z. Contents of major bioactive flavones in proprietary Traditional Chinese Medicine products and reference herb of Radix Scutellariae. J Pharm Biomed Anal. 50 (3): 298-306 (2009)
  11. You JH, Zuo Z, Lo CM, Zhou L, Yiu HH, Chau CT, Choi KC, Choi DK, Wong RS, Cheng G. Any effect of CYP2C9 variants on warfarin clearance in Chinese patients? Thromb Haemost. 97(5): 866-868 (2007).
  12. Zuo Z, Zhang L, Zhou L, Chang Q, Chow M. Intestinal absorption of hawthorn flavonoids--in vitro, in situ and in vivo correlations. Life Sci. 79(26): 2455-2462 (2006).
  13. Zhou L, Chow M, Zuo Z. Improved quality control method for Danshen products-Consideration of both hydrophilic and lipophilic active components.  J Pharm Biomed Anal. 41(3): 744-750 (2006).
  14. Zhou L, Zuo Z, Chow MS. Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J. Clin. Pharmcol. 45: 1345-1359 (2005).
  15. L.M. Zhou, J. Sirithunyalug, E. Yonemochi, T. Oguchi and K. Yamamoto: Complex Formation between Erythritol and 4-Hexylresorcinol. Journal of Thermal Analysis and Calorimetry. 59: 951-960 (2000) 
页首