呂愛平教授

  • 中醫藥學院院長;黃英豪博士中醫藥講座教授;羅守輝骨與關節疾病轉化醫學研究所所長;岑堯寬岑碧泉紀念癌症炎症研究中心主任;整合生物信息醫學與轉化科學研究所所長;香港浸會大學疼痛聯合研究中心主任
  • 中醫藥、臨床藥理與關節類及相關新藥研發專家
  • aipinglu@hkbu.edu.hk

呂愛平,香港浸會大學中醫藥學院院長、講座教授,香港浸會大學骨與關節疾病轉化醫學研究所所長,香港浸會大學整合生物信息醫學和轉化科學研究所所長,中國中醫科學院首席研究員。是國家杰出青年基金獲得者。是國家自然科學基金委員會醫學部諮詢委員會委員, 國家藥典委員會委員,全國科學技術名詞審定委員會中醫名詞術語委員會副主任委員, 國際標准化組織-TC249 中方Mirror Committee 主席。曾任中國中醫科學院臨床基礎研究所常務副所長(法人代表)、中國中醫研究院基礎理論研究所所長、江西本草天工科技有限公司(中藥固體制劑製造技術國家工程研究中心)董事長。

長期從事中醫證候分類治療類風濕關節炎的基礎和新藥研發工作。曾獲衛生部有突出貢獻中青年獎和中國標準突出貢獻獎。發表學術論文500 餘篇,其中包括Nature Medicine, Biomaterials, Briefings in Bioinformatics, Clinical Pharmacology and Therapeutics, Scientific Reports, Journal of Proteomic Research 等 SCI 收錄論文近200 篇。獲PCT和國家發明專利60 余項。編寫著作30 餘部。先後在Ohio State University、Lund University、香港科技大學和香港理工大學做訪問學者,多次受邀在國際學術會議上做特邀報告。

精選出版物

  • Li D, Liu J, Guo B, Liang C, Dang L, Lu C, He X, Cheung HY, Xu L, Lu C, He B, Liu B, Shaikh AB, Li F, Wang L, Yang Z, Au DW, Peng S, Zhang Z, Zhang BT, Pan X, Qian A, Shang P, Xiao L, Jiang B, Wong CK, Xu J, Bian Z, Liang Z, Guo DA, Zhu H, Tan W, Lu A, Zhang G. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun. 2016:7:10872.
  • Yao H, Jiang F, Lu A, Zhang G. Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs). Int J Mol Sci. 2016: 17(2). pii: E194.
  • Zhou W, Wang Y, Lu A, Zhang G. Systems Pharmacology in Small Molecular Drug Discovery. Int J Mol Sci. 2016:17(2). pii: E246.
  • Yu Y, Liang C, Lv Q, Li D, Xu X, Liu B, Lu A, Zhang G. Molecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers. Int J Mol Sci. 2016:11;17(3). pii: E358.
  • Wang C, Liu B, Xu X, Zhuang B, Li H, Yin J, Cong M, Xu W,, Lu A. (2016) Toward targeted therapy in chemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine. Oncotarget. [Epub ahead of print]
  • Tan Y, Liu X, Zhou K, He X, Lu C, He B, Niu X, Xiao C, Xu G, Bian Z, Zu X, Zhang G, Zhang W, Lu A. The Potential Biomarkers to Identify the Development of Steatosis in Hyperuricemia. PLoS One 2016:11(2):e0149043.
  • Yu Y, Liang C, Lv Q, Li D, Xu X, Liu B, Lu A, Zhang G. Molecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers. Int J Mol Sci. 2016 Mar 11;17(3).
  • Gong Y, Lin Y, Zhao N, He X, Lu A, Wei W, Jiang M. The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population. Mediators Inflamm. 2016;2016:7089137.
  • Ning Z, Liu Z, Song Z, Zhao S, Dong Y, Zeng H, Shu Y, Lu C, Liu Y, Lu A. A single marker choice strategy in simultaneous characterization and quantification of multiple components by rapid resolution liquid chromatography coupled with triple quadrupole tandem mass spectrometry (RRLC-QqQ-MS). J Pharm Biomed Anal. 2016 Mar 3;124:174-188.
  • Zhang B, Fu Y, Huang C, Zheng C, Wu Z, Zhang W, Yang X, Gong F, Li Y, Chen X, Gao S, Chen X, Li Y, Lu A, Wang Y. New strategy for drug discovery by large-scale association analysis of molecular networks of different species. Sci Rep. 2016 Feb 25;6:21872.
  • Zhou W, Wang Y, Lu A, Zhang G. Systems Pharmacology in Small Molecular Drug Discovery. Int J Mol Sci. 2016 Feb 18;17(2).
  • Tan Y, Liu X, Zhou K, He X, Lu C, He B, Niu X, Xiao C, Xu G, Bian Z, Zu X, Zhang G, Zhang W, Lu A. The Potential Biomarkers to Identify the Development of Steatosis in Hyperuricemia. PLoS One. 2016 Feb 18;11(2):e0149043.  
  • Wang C, Liu B, Xu X, Zhuang B, Li H, Yin J, Cong M, Xu W, Lu A. Toward targeted therapy in hemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine. Oncotarget. 2016 Jan 29. doi: 10.18632/oncotarget.7073. [Epub ahead of print]
  • Jiang M, Zha Q, Zhang C, Lu C, Yan X, Zhu W, Liu W, Tu S, Hou L, Wang C, Zhang W, Liang Q, Fan B, Yu J, Zhang W, Liu X, Yang J, He X, Li L, Niu X, Liu Y, Guo H, He B, Zhang G, Bian Z, Lu A. Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial. Sci Rep. 2015 Apr 15;5:9700.
  • Zhang X, Ng HL, Lu A, Lin C, Zhou L, Lin G, Zhang Y, Yang Z, Zhang H. Drug delivery system targeting advanced hepatocellular carcinoma: Current and future. Nanomedicine. 2016 Jan 7. pii: S1549-9634(16)00005-8. doi: 10.1016/j.nano.2015.12.381. [Epub ahead of print]
  • Li Y, Wang J, Xiao Y, Wang Y, Chen S, Yang Y, Lu A, Zhang S. A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis. J Ethnopharmacol. 2015:175:301-314.
  • Guo J, Qin S, Liang J, Lin T, Si L, Chen X, Chi Z, Cui C, Du N, Fan Y, Gu K, Li F, Li J, Li Y, Liang H, Liu J, Lu M, Lu A, Nan K, Niu X, Pan H, Ren G, Ren X, Shu Y, Song X, Tao M, Wang B, Wei W, Wu D, Wu L, Wu A, Xu X, Zhang J, Zhang X, Zhang Y, Zhu H; written; Chinese Society of Clinical Oncology (CSCO) Melanoma Panel. Chinese Guidelines on the Diagnosis and Treatment of Melanoma (2015 Edition). Ann Transl Med. 2015 Dec;3(21):322.
  • Zhao N, Li J, Li L, Niu XY, Jiang M, He XJ, Bian ZX, Zhang G, Lu A. Molecular network-based analysis of guizhi-shaoyao-zhimu decoction, a TCM herbal formula, for treatment of diabetic peripheral neuropathy. Acta Pharmacol Sin. 2015 Jun;36(6):716-723.
  • Zhang B, Lu C, Bai M, He X, Tan Y, Bian Y, Xiao C, Zhang G, Lu A, Li S. (2015) Tetramethylpyrazine identified by a network pharmacology approach amel iorates methotrexate-induced oxidative organ injury. J Ethnopharmacol.175:638-647.
  • Lin C, Ng HL, Pan W, Chen H, Zhang G, Bian Z, Lu A, Yang Z. Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy. Int J Mol Sci. 2015 Nov 11;16(11):26936-52.
  • Fatima S, Shi X, Lin Z, Chen GQ, Pan XH, Wu JC, Ho JW, Lee NP, Gao H, Zhang G, Lu A, Bian ZX. 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. Mol Oncol. 2016 Feb;10(2):195-212.
  • Jiang F, Liu B, Lu J, Li F, Li D, Liang C, Dang L, Liu J, He B, Badshah SA, Lu C, He X, Guo B, Zhang XB, Tan W, Lu A, Zhang G. Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems. Int J Mol Sci. 2015 Oct 9;16(10):23784-822.
  • Zhang B, Lu C, Bai M, He X, Tan Y, Bian Y, Xiao C, Zhang G, Lu A, Li S. Tetramethylpyrazine identified by a network pharmacology approach ameliorates methotrexate-induced oxidative organ injury. J Ethnopharmacol. 2015 Dec 4;175:638-47.
  • Xu S, Zhang T, Kompella SN, Yan M, Lu A, Wang Y, Shao X, Chi C, Adams DJ, Ding J, Wang C. Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci Rep. 2015 Sep 23;5:14261.
  • Niu X, Lu C, Xiao C, Ge N, Jiang M, Li L, Bian Y, Xu G, Bian Z, Zhang G, Lu A. The Crosstalk of Pathways Involved in Immune Response Maybe the Shared Molecular Basis of Rheumatoid Arthritis and Type 2 Diabetes. PLoS One. 2015:10(8):e0134990.
  • Li Y, Wang J, Xiao Y, Wang Y, Chen S, Yang Y, Lu A, Zhang S. A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis. J Ethnopharmacol. 2015 Dec 4;175:301-14.
  • Li P, Huang C, Fu Y, Wang J, Wu Z, Ru J, Zheng C, Guo Z, Chen X, Zhou W, Zhang W, Li Y, Chen J, Lu A, Wang Y. Large-scale exploration and analysis of drug combinations. Bioinformatics. 2015:31(12):2007-2016.
  • Shi N, Zhong LL, Han X, Ziea TC, Ng B, Bian Z, Lu A. Enhanced evidence-based chinese medicine clinical practice guidelines in Hong Kong: a study protocol for three common diseases. Evid Based Complement Alternat Med. 2015:2015:482706.
  • Chen GQ, Tang CF, Shi XK, Lin CY, Fatima S, Pan XH, Yang DJ, Zhang G, Lu AP, Lin SH, Bian ZX. Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism. Oncotarget. 2015:6(27):24148-24162.
  • Liu J, Dang L, Li D, Liang C, He X, Wu H, Qian A, Yang Z, Au DW, Chiang MW, Zhang BT, Han Q, Yue KK, Zhang H, Lv C, Pan X, Xu J, Bian Z, Shang P, Tan W, Liang Z, Guo B, Lu A, Zhang G. A delivery system specifically 2015: 52:148-160.
  • Liang C, Guo B, Wu H, Shao N, Li D, Liu J, Dang L, Wang C, Li H, Li S, Lau WK, Cao Y, Yang Z, Lu C, He X, Au DW, Pan X, Zhang BT, Lu C, Zhang H, Yue K, Qian A, Shang P, Xu J, Xiao L, Bian Z, Tan W, Liang Z, He F, Zhang L, Lu A, Zhang G. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat Med 2015: 21(3):288-294.
  • Li J, Liu Z, Guo M, Xu K, Jiang M, Lu A, Gao X. Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis. Evid Based Complement Alternat Med. 2015:2015:897914.
  • Wang Y, Guo Z, Chen X, Zhang W, Lu A, Wang Y. Multi-scale modeling of cell survival and death mediated by the p53 network: a systems pharmacology framework. Mol Biosyst. 2015 Nov;11(11):3011-21.
  • Fan L, Gong J, Fu W, Chen Z, Xu N, Liu J, Lu A, Li Z, Wu T, Ou A, Xie H. Gender-Related Differences in Outcomes on Acupuncture and Moxibustion Treatment Among Depression Patients. J Altern Complement Med. 2015 Nov;21(11):673-80.
  • Deng Y, Yang M, Xu F, Zhang Q, Zhao Q, Yu H, Li D, Zhang G, Lu A, Cho K, Teng F, Wu P, Wang L, Wu W, Liu X, Guo DA, Jiang B. Combined Salvianolic Acid B and Ginsenoside Rg1 Exerts Cardioprotection against Ischemia/Reperfusion Injury in Rats. PLoS One. 2015 Aug 17;10(8):e0135435.
  • Niu X, Lu C, Xiao C, Ge N, Jiang M, Li L, Bian Y, Xu G, Bian Z, Zhang G, Lu A. The Crosstalk of Pathways Involved in Immune Response Maybe the Shared Molecular Basis of Rheumatoid Arthritis and Type 2 Diabetes. PLoS One. 2015 Aug 7;10(8):e0134990.
  • Jiang F, Liu B, Lu J, Li F, Li D, Liang C, Dang L, Liu J, He B, Badshah SA, Lu C, He X, Guo B, Zhang XB, Tan W, Lu A, Zhang G. ) Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems. Int J Mol Sci. 2015:16(10):23784-23822.
  • Li J, Liu Z, Guo M, Xu K, Jiang M, Lu A, Gao X. Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis. Evid Based Complement Alternat Med. 2015;2015:897914.
  • Lu A, Xue C, Bian Z, Cho WC. TCM Zheng Classification and Clinical Trials 2014. Evid Based Complement Alternat Med. 2015;2015:538989.
  • Liu J, Dang L, Li D, Liang C, He X, Wu H, Qian A, Yang Z, Au DW, Chiang MW, Zhang BT, Han Q, Yue KK, Zhang H, Lv C, Pan X, Xu J, Bian Z, Shang P, Tan W, Liang Z, Guo B, Lu A, Zhang G. A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts. Biomaterials. 2015 Jun;52:148-60.
  • Shi N, Zhong LL, Han X, Ziea TC, Ng B, Bian Z, Lu A. Enhanced evidence-based Chinese medicine clinical practice guidelines in Hong Kong: a study protocol for three common diseases. Evid Based Complement Alternat Med. 2015;2015:482706.
  • Gong Y, Liu L, He X, Zhao H, Yang J, Li L, Lu A, Lin Y, Jiang M. The th17/treg immune balance in ulcerative colitis patients with two different chinese syndromes: dampness-heat in large intestine and spleen and kidney yang deficiency syndrome. Evid Based Complement Alternat Med. 2015;2015:264317.
  • Liang C, Li D, Zhang G, Li H, Shao N, Liang Z, Zhang L, Lu A, Zhang G. Comparison of the methods for generating single-stranded DNA in SELEX. Analyst. 2015 May 21;140(10):3439-44.
  • Kwan HY, Niu X, Dai W, Tong T, Chao X, Su T, Chan CL, Lee KC, Fu X, Yi H, Yu H, Li T, Tse AK, Fong WF, Pan SY, Lu A, Yu ZL. Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers. Sci Rep. 2015 Mar 13;5:9114
  • He YX, Liu J, Guo B, Wang YX, Pan X, Li D, Tang T, Chen Y, Peng S, Bian Z, Liang Z, Zhang BT, Lu A, Zhang G. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. Sci Rep. 2015 Mar 9;5:8856.
  • Du Z, Liu Z, Ning Z, Liu Y, Song Z, Wang C, Lu A. Prospects of boswellic acids as potential pharmaceutics. Planta Med. 2015 Mar;81(4):259-71.
  • Jia W, Lu A, Chan K, Gustafsson MG, Liu P. Translational research in complementary and alternative medicine 2014. Evid Based Complement Alternat Med. 2015;2015:427508.
  • Li P, Huang C, Fu Y, Wang J, Wu Z, Ru J, Zheng C, Guo Z, Chen X, Zhou W, Zhang W, Li Y, Chen J, Lu A, Wang Y. Large-scale exploration and analysis of drug combinations. Bioinformatics. 2015 Jun 15;31(12):2007-16.

*corresponding author

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