張宏杰教授

張宏杰教授1985年於雲南大學化學系獲學士學位,並於1988年及1994年於中國科學院昆明植物研究所植物化學研究室先後獲得碩士和博士學位。他於1991-2002年在中國科學院昆明植物研究所植物化學室任職助理研究員/副研究員/研究員,並於2003-2011年期間在美國伊利諾大學芝加哥分校藥學院任職研究助理教授/研究副教授。期間作為課題主持人和合作者,張教授參與了有關天然藥物丶傳統草藥(包括中藥)丶有機合成和生物合成等方面的研究項目。

張宏杰教授從事生物活性(包括抗癌防癌丶抗艾滋病毒丶抗流感病毒丶抗丙肝病毒丶抗腳氣真菌、抗牙菌、抗結核病和抗瘧疾等)指導下,對天然資源特別是嶺南植物中的生物活性物質進行分離丶鑒定,並進一步對分離提純的化合物作體內和體外活性評價丶結構修飾、化學合成及機制等的研究。他目前已建立可供高通量活性篩選的化合物和天然提取物庫。張宏杰教授已發表論文150餘篇,並有20多項授權專利。他課題組針對石斛皮膚保護和美白的研究已有系列市場銷售產品。

精選出版物

  1. Xia YX,  Lam CS,  Li WF, Sarwar MS, Liu KL, Lee KM, Zhang HJ,* Tsang SW.* Flexicaulin A, an ent-kaurane diterpenoid, activates p21 and inhibits the proliferation of colorectal carcinoma cells through a non-apoptotic mechanism. International Journal of Molecular Sciences 2019, 20 (8), article 1917 (14 pages).
  2. Kos J, Ku CF, Kapustikova I, Oravec M, Zhang HJ,* Jampilek J.* 8-Hydroxyquinoline-2-carboxanilides as antiviral agents against avian influenza virus. ChemistrySelect, 4 (15), 4582-4587.
  3. Xu XY, Tsang SW, Guan YF, Liu KL, Pan WH, Lam CS, Lee KM, Xia YX, Wen-Jian Xie, Wong WY, Lee MML, Tai WCS, Zhang HJ.* The in vitro and in vivo antitumor effects of plant-derived miliusanes and their induction of cellular senescence. Journal of Medicinal Chemistry 2019, 62 (3), 1541-1561.
  4. Wang MZ,* Si TX, Ku CF, Zhang HJ,* Li ZM, Zheng-Ming Li, Chan ASC.* Synthesis of javanicunines A and B, 9-deoxy-PF1233s A and B, and absolute configuration establishment of javanicunine B. The Journal of Organic Chemistry 2019, 84 (2), 831-839.
  5. Song X, Wei YX, Lai KM, He ZD,* Zhang HJ.* In vivo antifungal of dipyrithione against Trichophyton rubrum on guinea pig dermatophytosis models. Biomedicine & Pharmacotherapy 2018, 108, 558-564.
  6. Pan WH, Xu XY, Shi N, Tsang SW, Zhang HJ.* Antimalarial activity of plant metabolites. International Journal of Molecular Sciences 2018, 19 (5), article 1382 (40 pages).
  7. Zhao CL, Sarwar MS, Ye JH, Ku CF, Li WF, Luo GY, Zhang JJ. Xu J, Huang ZF, Tsang SW, Pan LT,* Zhang HJ.* Isolation, evaluation of bioactivity and structure determination of amethinol A, a prototypic amethane diterpene from Isodon amethystoides bearing a six/five/seven-membered carbon-ring system. Acta Crystallographica Section C: Structural Chemisty 2018, C74, 635-640.
  8. Wang MZ,* Si TX, Ku CF, Li XW, Li ZM, Zhang HJ,* Chan ASC.* Total synthesis and absolute configuration reassignment of mollenines A and B. Organic Chemistry Frontiers 2018, 5 (6), 954-957.
  9. Wang MZ,* Ku CF, Si TX, Tsang SV, Lv XM, Li XW, Li ZM, Zhang HJ,* Chan ASC.*  Concise synthesis of natural phenylphenalenone phytoalexins and a regioisomer. Journal of Natural Products 2018, 81 (1), 98-105.
  10. Xia YX, Xiao HT, Liu KL, Zhang HJ,* Tsang SW.* Resveratrol ameliorative the severity of fibrogenesis in mice with experimental chronic pancreatitis. Molecular Nutrition and Food Research 2018, 62 (16), e1700561.
  11. Zhu Y, Pan WH, Ku CF, Zhang HJ,* Tsang SW.* Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents. European Journal of Medicinal Chemistry 2018, 143 (1 Jan), 1254-1260.
  12. Tsang NY, Chik WI, Sze LP, Tsang SW, Zhang HJ.* The use of naphthoquinones and furano-naphthoquinones as anti-invasive agents. Current Medicinal Chemistry 2018, 25 (38), 5007-5036.
  13. Zhang HJ,* Rumschlag-Booms E, Guan YF, Wang DY, Liu KL, Li WF, Nguyen VH, Cuong NM, Soejarto DD, Fong HHS, Rong LJ*. Potent inhibitor to drug-resistant HIV-1 strains identified from the medicinal plant Justicia gendarussa. Journal of Natural Products 2017, 80 (6), 1798-1807.
  14. Guo L, Tsang SW, Zhang T, Liu KL, Guan YF, Wang B, Sun HD, Zhang HJ*, Wong MS.* Efficient semi-synthesis of (-)-pseudoirroratin A from (-)-flexicaulin A and assessment of their antitumor activities. ACS Medicinal Chemistry Letters 2017, 8 (3), 372-376.
  15. Sarwar MS, Zhang HJ, Tsang SW.* Perspectives of plant natural products in inhibition of cancer invasion and metastasis by regulating multiple signaling pathways. Current Medicinal Chemistry 2018, 25 (38), 5057-5087.
  16. Song X, Xia YX, He ZD, Zhang HJ.* A review of natural products with anti-biofilm activity. Current Organic Chemistry 2018, 22 (8), 789-817.
  17. Tsang NY, Zhao LH, Tsang SW, Zhang HJ.* Antiviral activity and molecular targets of plant natural products against avian influenza virus. Current Organic Chemistry 2017, 21 (18), 1777-1804.
  18. Zhang HJ,* Rumschlag-Booms E, Guan YF, Liu KL, Wang DY, Li WF, Nguyen VH, Cuong NM, Soejarto DD, Fong HHS, Rong LJ.* Anti-HIV diphyllin glycosides from Justicia gendarussa. Phytochemistry 2017, 136 (April), 94-100.
  19. Zhang HJ,* Li WF, Fong HHS, Soejarto DD. Discovery of bioactive compounds by UIC-ICBG drug discovery program in the 18 years since 1998. Molecules 2016, 21 (11), 1448 (17 pages). r)
  20. Li JX, Li QJ, Guan YF, Song X, Liu YH, Zhang JJ, Li WF, Du J, Zhu M, Banas JA, Li XN, Pan LT,* Zhang HJ.* Discovery of Antifungal Constituents from the Miao Medicinal Plant Isodon Flavidus. Journal of Ethnopharmacology 2016, 191 (15 September), 372-378.
  21. Song X, He J, Xu H, Hu XP, Wu XL, Wu HQ, Wu XL, Wu HQ, Liu LZ, Liao CH, Zeng Y, Li Y, Hao Y, Xu CS, Fan L, Zhang J*, Zhang HJ,* He ZD.* The Antiviral Effects of Acteoside and the Underlying IFN-γ-Inducing Action. Food & Function 2016, 7, 3017-3030.
  22. Guan YF, Song X, Qiu MH, Luo SH, Wan BJ, Hung NV, Cuong NM, Soejarto DD, Fong HHS, Franzblau SG, Li SH, He ZD,* Zhang HJ.* Bioassay-guided isolation and structural modification of the anti-TB resorcinols from Ardisia gigantifolia. Chemical Biology & Drug Design 2016, 88 (2), 293-301.
  23. Wang MZ, Xie WJ, Guan YF, Song X, Hung NV, Cuong NM, Santarsiero BD, Fong HHS, Soejarto DD, Zhang HJ.* Bioactive constituents from Radermachera boniana. ChemistrySelect 2016, 1 (8), 1575-1579.
  24. Tsang SW*, Guan YF, Wang J, Bian ZX, Zhang HJ.* Inhibition of pancreatic oxidative damage by stilbene derivative dihydro-resveratrol: implication for treatment of acute pancreatitis. Scientific Reports 2016, 6, Article number: 22859 (15 pages).
  25. Lin ZS, Ku CF, Guan YF, Xiao HT, Shi XK, Wang HQ, Bian ZX, Tsang SW.* Zhang HJ.* Dihydro-resveratrol ameliorates lung injury in rats with cerulean-induced acute pancreatitis. Phytotherapy Research 2016, 30 (4), 663-670.
  26. Guan YF, Wang DY, Tan GT, Hung NV, Cuong NM, Pezzuto JM, Fong HHS, Soejarto DD, Zhang HJ.* Litsea Species as Potential Antiviral Plant Sources. American Journal of Chinese Medicine 2016, 44 (2), 275-290.
  27. Li WF, Wang J, Zhang JJ, Song S, Ku CF, Zou J, Li JX, Rong LJ, Pan LT,* Zhang HJ.* Henrin A: A new anti-HIV ent-kaurane diterpene from Pteris henryi. International Journal of Molecular Sciences 2015, 16 (11), 27978-27987.
  28. Tsang SW,* Zhang HJ, Lin ZS, Mu HX, Bian ZX.* Anti-fibrotic effect of trans-resveratrol on pancreatic stellate cells. Biomedicine & Pharmacotherapy 2015, 71 (1), 91-97.
  29. Pan WH, Liu KL, Guan YF, Tan GT, Hung NV, Cuong NM, Doejarto DD, Pezzuto JM, Fong HHS, Zhang HJ.* Bioactive compounds from Vitex leptobotrys. Journal of Natural Products 2014, 77 (3), 663-667.
  30. Li SH, Qiu SX, Yao P, Sun HD, Fong HHS, Zhang HJ.* Compounds from the fruits of the popular European medicinal plant Vitex agnus-castus in chemoprevention via NADP(H) : quinone oxidoreductase type 1 induction. Evidence-Based Complementary and Alternative Medicine 2013, 2013: Article ID 432829, 7pages.
  31. Zou J, Pan LT,* Li QJ, Pu JX, Yao P, Zhu M, Banas JAB, Zhang HJ,* Sun HD. Rubesanolides C-E: The abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity. Organic & Biomolecular Chemistry 2012, 10 (26), 5039-5044.
  32. Yang JH, Kondratyuk TP, Jermihov KC, Marler LE, Qiu X, Choi YS, Cao HM, Yu R, Sturdy M, Hung R, Liu Y, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HHS, Chen YG,* Zhang HJ.* Bioactive compounds from the Fern Lepisorus contortus. Journal of Natural Products 2011, 74 (2), 129-136.
  33. Zou J, Pan LT,* Li QJ, Zhao JH, Pu JX, Yao P, Gong NB, Lu Y, Kondratyuk TP, Pezzuto JM, Fong HHS, Zhang HJ,* Sun HD. Rubesanolides A and B: diterpenoids from Isodon rubescens. Organic Letters 2011, 13 (6), 1406-1409.
  34. Rumschlag-Booms E,* Zhang HJ, Soejarto DD, Fong HHS, Rong LJ. Development of an antiviral screening protocol: One-Stone-Two-Birds. Journal of Antivirals & antiretrovirals 2011, 3 (1), 8-10.
  35. Yang JH,Kondratyuk TP, Marler LE, Qiu X, Choi YS, Cao HM, Sturdy M, Pegan S, Liu Y, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HHS, Chen YG,* Zhang HJ.* Isolation and evaluation of kaempferol glycosides from Neocheiropteris palmatopedata. Phytochemistry 2010, 71 (5-6), 641-647.
  36. Zhang HJ,* Rothwangl K, Mesecar AD, Sabahi A, Rong LJ,* Fong HHS. Lamiridosins, hepatitis C virus entry inhibitors from Lamium album. Journal of Natural Products 2009, 72 (12), 2158-2162.
  37. Ma CM, Musoke FS, Tan GT,* Sydara K, Bouamanivong S, Southavong B, Soejarto DD, Fong HHS, Zhang HJ.*  Study of antimalarial activity of chemical constituents from Diospyros quaesita Thw. (Ebenaceae). Chemistry & Biodiversity 2008, 5 (11), 2442-2448.
  38. Libman A, Zhang HJ,* Ma CM, Southavong B, Sydara K, Bouamanivong S, Tan GT, Fong HHS, Soejarto DD.* An antimalarial steroidal glycoside from Gongronema napalense. Asian Journal of Traditional Medicines 2008, 3 (6), 203-210.
  39. Jutiviboonsuk A, Zhang HJ,* Kondratyuk TP, Herunsalee A, Chaukul W, Pezzuto JM, Fong HHS, Bunyapraphatsara N.* Isolation and characterization of cancer chemopreventive compounds from Barringtonia maunwongyathiae. Pharmaceutical Biology 2007, 45 (3), 185-194.
  40. Zhang HJ,* Ma CY, Hung NV, Cuong NM, Tan GT, Santarsiero BD, Mesecar AD, Soejarto DD, Pezzuto JM, Fong HHS.* Miliusanes, a class of cytotoxic agents from Miliusa sinensis. Journal of Medicinal Chemistry 2006, 49 (2), 693-708.
  41. He ZD, Ma CY, Tan GT, Sydara K, Bouamanivong S,Tamez P, Southavong B, Soejarto DD, Pezzuto JM, Fong HHS,* Zhang HJ.* Rourinoside and rouremin, antimalarial constituents from Rourea minor. Phytochemistry 2006, 67 (13), 1378-1384.
  42. Homhual S, Bunyapraphatsara N,* Kondratyuk T, Herunsalee A, Chaukul W, Pezzuto JM, Fong HHS, Zhang HJ.* Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza. Journal of Natural Products 2006, 69 (3), 421-424.
  43. Soejarto DD,* Zhang HJ, Fong HHS, Tan GT, Ma CM, Gyllenhaal C, Riley MC, Kadushin MR, Franzblau SG, Bich TQ, Cuong NM, Hiep NT, Loc PK, Xuan LT, Hai NV, Hung NV, Chien NQ, Vu BM, Ly HM, Southavong B, Sydara K, Bouamanivong S, Pezzuto JM, Rose W, Dietzman G, Miller B, Thuy TV.Studies on Biodiversity of Vietnam and Laos” 1998-2005: Examining the Impacts. Journal of Natural Products 2006, 69 (3), 473-481.
  44. Zhang HJ,* Hung NV, Cuong NM, Soejarto DD, Pezzuto JM,  Fong HHS, Tan GT.* Sesquiterpenes and Butenolides, Natural anti-HIV constituents from Litsea verticillata. Planta Medica 2005, 71 (5), 452-457.
  45. Jutiviboonsuk A, Zhang HJ,* Tan GT, Ma CM, Hung NV, Cuong NM, Bunyapraphatsara N,* Soejarto DD, Fong HHS. Bioactive constituents from the roots of Bursera tonkinensis. Phytochemistry 2005, 66 (23), 2745-2751.
  46. Zhang HJ, Sydara K, Tan GT, Ma CM, Southavong B, Soejarto DD, Pezzuto JM, Fong HHS.* Bioactive constituents from Asparagus cochinchinensis. Journal of Natural Products 2004, 67 (2), 194-200.
  47. Zhang HJ, Tan GT, Santarsiero BD, Mesecar AD, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HHS.* New sesquiterpenes from Litsea verticillata. Journal of Natural Products 2003, 66 (5), 609-615.
  48. Zhang HJ, Tan GT, Hoang VD, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HHS.* Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. Journal of Natural Products 2003, 66 (2), 263-268.
  49. Zhang HJ, Tan GT, Hoang VD, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HHS.* Natural anti-HIV agents. Part III. Litseaverticillols A-H, novel sesquiterpenes from Litsea verticillata. Tetrahedron 2003, 59 (2), 141-148.
  50. Li SH, Zhang HJ,* Niu XM, Yao P, Sun HD, Fong HHS.* Chemical constituents from Amentotaxus yunnanensis and Torreya yunnanensis. Journal of Natural Products 2003, 66 (7), 1002-1005.
  51. Li SH, Zhang HJ,* Niu XM, Yao P, Sun HD, Fong HHS.* Novel taxanes from the Chinese Yew Taxus yunnanensis. Tetrahedron 2003, 59 (1), 37-45.
  52. Li SH, Zhang HJ,* Yao P, Niu XM, Xiang W, Sun HD.* Two new lignans from Taxus yunnanensis. Chinese Journal of Chemistry 2003, 21, 926-930.
  53. Zhang HJ, Tamez P, Aydogmus Z, Tan GT, Saikawa Y, Hashimoto K, Nakata M, Hung NV, Xuan LT, Cuong NM, Soejarto DD, Pezzuto JM, Fong HHS.* Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva. Planta Medica 2002, 68 (12), 1088-1091.
  54. Zhang HJ, Lu ZZ, Tan GT, Qiu SX, Farnsworth NH, Pezzuto JM, Fong HHS.* Polyacetyleneginsenoside, a novel triterpene saponin from Panax ginseng. Tetrahedron Letters 2002, 43 (6), 973-977.
  55. Zhang HJ, Fan ZT, Tan GT, Chai HB, Pezzuto JM, Sun HD, * Fong HHS.* Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata. Journal of Natural Products 2002, 65 (2), 215-217.
  56. Zhang HJ, Qiu SX, Tamez P, Tan GT, Aydogmus Z, Hung NV, Cuong NM, Angerhofer C, Soejarto DD, Pezzuto JM, Fong HHS.* Antimalaria agents from plants II.  Decursivine, a new antimalarial indole alkaloid from Rhaphidophora decursiva”.  Pharmaceutical Biology 2002, 40 (3), 221-224.
  57. Li SH, Zhang HJ, Qiu SX,* Niu XM, Santarsiero BD, Mesecar AD, Fong HHS, Farnsworth NR, Sun HD.* Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus. Tetrahedron Letters 2002, 43 (29), 5131-5134.
  58. Li SH, Zhang HJ,* Niu XM, Yao P, Sun HD, Fong HHS.* Taxuyunnanines S-V, new taxoids from Taxus yunnanensis. Planta Medica 2002, 68 (3), 253-257.
  59. Li SH, Zhang HJ,* Yao P, Niu XM, Sun HD.* Non-taxane compounds from the bark of Taxus yunnanensis. Journal of Asian Natural Products Research 2002, 4 (2), 147-154.
  60. Zhang HJ, Tan GT, Hoang VD, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HHS.* Natural anti-HIV agents Part II. Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata. Tetrahedron Letters 2001, 42 (49), 8587-8591.
  61. Zhang HJ, Tamez P, Hoang VD, Tan GT, Hung NV, Xuan LT, Huong LM, Cuong NM, Thao DT, Soejarto DD, Fong HHS,* Pezzuto JM. Antimalarial compounds from Rhaphidophora decursiva. Journal of Natural Products 2001, 64 (6), 772-777.
  62. Li SH, Zhang HJ,* Yao P, Sun HD, Fong HHS* Taxane diterpenoids from the bark of Taxus yunnanensis. Phytochemistry 2001, 58 (2), 369-374.
  63. Li SH, Zhang HJ,* Yao P, Sun HD, Fong HHS* Rearranged taxanes from the bark of Taxus yunnanensis. Journal of Natural Products 2000, 63 (11), 1488-1491.
  64. Li WK, Gu CG, Zhang HJ, Awang DVC, Fitzloff JF, Fong HHS., van Breemen RB.* Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian Ginseng) and Panax quinquefolius L. (North American Ginseng). Analytical Chemistry 2000, 72 (21), 5417-5422.
  65. Li SH, Zhang HJ,* Yao P, Sun HD. Two new taxoids from bark of Taxus yunnanensisChinese Chemical Letters 1998, 9 (11), 1017-1020.
  66. Zhang HJ,* Mu Q, Xiang W, Yao P, Sun HD, Takeda Y. Intramolecular transesterified taxanes from Taxus yunnanensis. Phytochemistry 1997, 44 (5), 911-915.
  67. Takeda Y,* Zhang HJ, Matsumoto T, Otsuka H, Oosio Y, Honda G, Tabata M, Fujita T, Sun HD, Sezik E, Yesilada E. Megastigmane glycosides from Salvia nemorosa. Phytochemistry 1997, 44 (1), 117-120.
  68. Takeda Y,* Zhang HJ, Masuda T, Honda G, Otsuka H, Sezik E, Yesilada E, Sun HD. Megastigmane glucosides from Stachys byzantina. Phytochemistry 1997, 44 (7), 1335-1337.
  69. Zhang HJ, Sun HD,* Takeda Y. Four new taxanes from the roots of Taxus yunnanensis.” Journal of Natural Products 1995, 58 (8), 1153-1159.
  70. Zhang HJ, Takeda Y,* Sun HD.* Taxanes from Taxus yunnanensis. Phytochemistry 1995, 39 (5), 1147-1151.
  71. Zhang HJ, Takeda Y,* Matsumoto T, Minami Y, Yoshida K, Xiang W, Mu Q, Sun HD.* Taxol related diterpenes from the roots of Taxus yunnanensis. Heterocycles 1994, 38 (5), 975-980.
  72. Zhang HJ, Takeda Y,* Minami Y, Yoshida K, Matsumoto T, Xiang W, Mu Q, Sun HD.* Three new taxanes from the roots of Taxus yunnanensis. Chemistry Letters 1994, 957-960.
  73. Zhang HJ, Takeda Y,* Minami Y, Yoshida K, Unemi N, Mu Q, Xiang W, Matsumoto T, Sun,Handong. Taxanes from the roots of Taxus yunnanensis. Yunnan Zhiwu Yanjiu Botanica (Acta Botanica Yunnanica) 1993, 15 (4), 424-426.
  74. Zhang HJ, Sun HD.* Diterpenoids from Rabdosia kunmingensis. Phytochemistry 1989, 28 (12), 3405-3409.
  75. Zhang HJ, Sun HD.* Diterpenoids from Rabdosia flexicaulis. Phytochemistry 1989, 28 (12), 3534-3536.
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