李敏教授

  • 中醫藥學院副院長;教學科研部教授;中醫學學士及生物醫學理學士(榮譽)學位及中醫學碩士學位課程主任;高智明伉儷柏金遜症研究中心主任
  • 中醫內科學、中藥藥理學、神經退行性疾病及心腦血管疾病專家
  • limin@hkbu.edu.hk

李敏教授,為香港浸會大學中醫藥學院副院長、中醫學學士及生物醫學理學士(榮譽)學位及中醫學碩士學位課程主任及高智明伉儷柏金遜症研究中心主任。李敏教授1985年大學本科畢業獲得醫學學士學位,1988年獲得醫學碩士學位,1998年獲得日中醫學會笹川醫學獎學金留學日本,2001年獲得西醫學博士學位。李敏教授於中國大陸、日本和香港從事中醫臨床、教學和研究工作近三十年,曾先後從師於中國大陸著名中醫專家鄧鐵濤教授、熊繼柏教授。2007年李敏教授獲得由中國中醫藥學會頒發的“全國首屆傑出女中醫師”稱號,2013年獲得香港浸會大學優秀教師獎。李敏教授目前主要從事神經系統退行性疾病包括柏金遜症和阿氏海默症的中醫臨床治療與基礎研究工作。李敏教授的課題組先後開展了中藥複方治療柏金遜症、阿氏海默症的隨機對照雙盲的臨床研究,從中藥中篩選小分子天然自噬誘導劑治療神經退行性疾病的分子藥理研究及治療神經退行性疾病的中藥新藥研發工作。

目前,李敏教授課題組的研究方向為:(1) 中藥複方治療柏金遜症和阿氏海默症的隨機雙盲對照的臨床研究和中西藥合用的相互作用及安全性研究;(2) 中藥複方、提取物和中藥活性組分的神經保護效果和作用機制的研究; (3) 中藥複方、提取物和中藥活性組分保護心腦血管內皮細胞的藥效及作用機理研究。具體資訊可以瀏覽李敏教授的實驗室主頁: http://cpdr.hkbu.edu.hk

精選出版物

Google Scholar Citations: 10,192; h-index: 32; i10-index: 83 (July, 2020)

[*, corresponding author(s); †, contribution equally/sharing first authorship]

 

  1. Yuen CS, Chua KK, Lau WH, Zhuang ZY, Chow HY, Li M.* (2020) “The effect of conduction exercise and self-acupressure in treatment of Parkinson's disease: a pilot study”, eCAM (Accepted)
  2. Yadav SK, Ir R, Jeewon R, Doble M, Hyde KD, Kaliappan I, Jeyaraman R, Reddi RN, Krishnan J, Li M.* & Durairajan SSK* (2020) “A mechanistic review on medicinal mushrooms-derived bioactive compounds: potential mycotherapy for alleviating neurological disorders”. Planta Med. 2020 July 14. doi:10.1055/a-1177-4834
  3. Cai CZ, Yang CB, Zhuang XX, Yuan NN, Wu MY, Tan JQ, Song JX, Cheung KH, Su HX, Wang YT, Yue ZY, Li M*, Lu JH.* (2020) “NRBF2 is a Rab7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of Rab7 for degradation”. Autophagy 2020 doi:10.1080/15548627.2020.1760623.
  4. Wang SQ, Wang N, Zheng YF, Yang BW, Liu PX, Zhang FX, Li M, Song JX, Chang X, Wang ZY*. (2020) “Caveolin-1 inhibits breast cancer stem cells via c-Myc-mediated metabolic reprogramming”, Cell Death & Disease , 2020 June 11. doi:10.1038/s41419-020-2667-x
  5. Wu MY, L Liu, Wang EJ, Xiao HT, Cai CZ, Wang J, Su HX, Wang YT, Tan JQ, Zhang Z, Wang J, Yao M, Ouyang DF, Yue Z, Li M*, Chen Y*, Bian ZX*, Lu JH.* (2020) “PI3KC3 subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation”. Autophagy, 2020 Mar 11. doi:10.1080/15548627.2020.1741332.
  6. Ji F, Zhu Z, Zhang M, Zhang H, Zhu L, Cai X, Liu W, Song J, Li M*, Cai Z*. (2020) 6-OH-BDE-47 exposure-induced Parkinson's disease pathology in Sprague Dawley rat” . Sci Total Environ. 2020 Apr 1; 711:135184. doi:10.1016/j.scitotenv.2019.135184.
  7. Chan KH, Ng RCL*, Jian M, Bunting M, Ma OKF, Kwan JSC, Zhou GJ, Senthilkumar K, Iyaswamy A, Li M, Leung KMY, Durairajan SSK, Lam KSL, Chung SK, Chan PK, Chu LW, Festenstein R. (2020) “Chronic oral administration of AdipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer's disease mouse model”. Molecular Psychiatry  2020 Mar 4. doi: 10.1038/s41380-020-0701-0.
  8. Dong Y, Hu YJ, Li M, Feng D, Song JX, Li M, Medina DL, Tan JQ, Zhang ZH, Sarkar S, Yue ZY, Zong WX, Lu JH*. (2020) “Chemical Autophagy Modulators: a Systematic Review Focusing on Methodology”, Autophagy 2020 Feb;16(2):195-202. doi:10.1080/15548627.2019.1704119.
  9. Zhuang XX, Wang SF, Tan Y, Song JX, Zhu Z, Wang ZY, Wu MY, Cai CZ, Huang ZJ, Tan JQ, Su HX*, Li M*, Lu JH*. (2020) “Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models.” Cell Death and Diseases. 2020,11:128. doi:10.1038/s41419-020-2322-6
  10. Malampati S, Song JX, Tong BCK, Nalluri A, Yang CB, Wang ZY, Cheung KH, Sreenivasmurthy SG, Zhu Z, Liu J, Krishnamoorthi S, Iyaswamy A, Cheung KH, Lu JH, Li M.* (2020) “Targeting Aggrephagy for the Treatment of Alzheimer's Disease”. Cells. 2020 Jan 28;9(2):311.doi:10.3390/cells9020311.
  11. Liu JY, Liu C, Zhang JF, Zhang YM, Liu KY, Song JX, Sreenivasmurthy SG, Wang ZY, Shi YS, Chu CC, Zhang Y, Wu CS, Deng XH, Liu XY, Song J, Zhuang RQ, Huang SQ, Zhang PF, Li M*, Wen L*, Zhang YW, Liu G.*(2020) A Self-Assembled α-Synuclein Nanoscavenger for Parkinson's Disease”. ACS Nano, 6 Feb. 2020. doi:10.1021/acsnano.9b06453
  12. Yang CB, Zhu Z, Tong BCT, Iyaswamy A, Xie WJ, Zhu Y, Sreenivasmurthy SG, Senthilkumar K, Cheung KH, Song JX, Zhang HJ, Li M.* (2020) “A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38”. Redox Biology, 2020. Jan 28:101445. doi:10.1016/j.redox.2020.101445.
  13. Wang ZY, Yang CB, Liu J, Tong BCK, Zhu Z, Malampati S, Sreenivasmurthy SG, Cheung KH, Iyaswamy A, Su CF, Lu JH, Song JX*, Li M.* (2020) “A curcumin derivative activates TFEB and protects against Parkinsonian neurotoxicity in vitro”. Inter. J. Mol. Sci. 2020, 21, 1515; doi:10.3390/ijms21041515
  14. Iyaswamy A, Krishnamoorthi Senthil K, Song JX, Yang CB, Kaliyamoorthy V, Sreenivasmurthy SG, Wang ZY, Malampati S, Durairajan SSK, Li M.* (2020) “NeuroDefend, a novel traditional Chinese medicine, attenuates amyloid-beta and tau pathology in experimental Alzheimer's disease models.” J. Food and Drug Analysis 2020 Jan;28(1):132-146. doi: 10.1016/j.jfda.2019.09.004
  15. Song JX, Malampati S, Zeng Y, Yang CB, Cheung KH, Sreenivasmurthy SG, Wang ZY, Iyaswamy A, Lu JH, Tong BCK, Zhu Z, Shang WB, Tang CT, Xu NG, Li M.* (2019) “A novel TFEB activator ameliorates APP and Tau pathology and improves cognitive deficits in Alzheimer disease transgenic mice”, Aging Cell doi:10.1111/acel.13069
  16. Kwan CS, Wang T, Li M, Chan ASC, Cai ZW, Leung KCF.* (2019) “Type III-C Rotaxane Dendrimers: Synthesis, Dual Size Modulation and In Vivo Evaluation”, ChemComm (Camb). 2019 Nov 18; 55(89):13426-13429. doi:10.1039/c9cc06200a.
  17. Wang N, Yang BW, Muhetaer G, Wang SQ, Zheng YF, Lu JH, Li M., Zhang FX, Situ HL, Lin Y, Wang ZY*. (2019) “XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy” Biomedicine & Pharmacotherapy 2019 Dec; 120:109519. doi:10.1016/j.biopha.2019.109519.
  18. Cai CZ, Zhou HF, Yuan NN, Wu MY, Wang SF, Lee MY, Wang YT, Yang CB, Li M, Tan JQ, Lu JH.* (2019) “Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation”, Phytomedicine. 2019, 61. 152842.
  19. Wu AJ, Tong BC, Huang AS, Li M, Cheung KH. (2019) “Mitochondrial calcium signaling as a therapeutic target for Alzheimer's disease ”, Curr Alzheimer Res. 2019 Dec 9. doi:10.2174/1567205016666191210091302
  20. Naushad M, Durairajan SSD, Bera AK, Senapati S, Li M. (2019) “Natural Compounds with Anti-BACE1 Activity as Promising Therapeutic Drugs for Treating Alzheimerʼs Disease”, Planta Med. 2019, 85:1-10. doi:10.1.55/a-1019-9819
  21. Ji F, Wei J, Luan H, Li M*, Cai ZW*. (2019) “Study of metabolic disorders associated with BDE-47 exposure in Drosophila model by MS-based metabolomics” Ecotoxicol Environ Saf. 2019 Nov 30; 184:109606. doi:10.1016/j.ecoenv.2019.109606.
  22. Yuen CS, Chua KK, Lau WH, Zhuang ZY, Chow HY, Li M.* (2019) “The effect of conduction exercise and self-acupressure in treatment of Parkinson’s disease: Protocol for a pilot study”, J. Tradi. Chi. Med. Sci. https://doi.org/10.1016/j.jtcms.2019.07.001 .
  23. Ji FF, Sreenivasmurthy SG, Wei J, Shao X, Luan H, Zhu L, Song JX, Liu LF, Li M*, Cai ZW*.(2019) “Study of BDE-47 induced Parkinson's disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis. ” J Hazard Mater. 2019 Jun 6; 378:120738. doi:10.1016/j.jhazmat.2019.06.015
  24. Zhu Z, Yang CB, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Liu J, Wang ZY, Song JX, Lu JH, Li M.* (2019) “Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease.”, Inter. J. Mol. Sci. 2019 Feb 8;20(3). pii: E728. doi:10.3390/ijms20030728.
  25. Wang J, Wu MY, Tan JQ, Li M, Lu JH. (2019) “High content screening for drug discovery from traditional Chinese medicine.”, Chin Med. 2019 Feb 28;14:5. doi: 10.1186/s13020-019-0228-y. eCollection 2019.
  26. Yuan NN, Cai CZ, Wu MY, Su HX, Li M, Ren JY, Tan JQ, Lu J.H.* (2019) “Canthin-6-one accelerates alpha-synuclein degradation by enhancing UPS activity: drug target identification by CRISPR-Cas9 whole genome-wide screening technology”, Front. Pharmacol. 28 January 2019, https://doi.org/10.3389/fphar.2019.00016
  27. Wang ZY, Sravan GS, Song JX, Liu JY*, Li M.*(2018) “Strategies for Brain-targeting Liposomal Delivery of Small Hydrophobic Molecules in the Treatment of Neurodegenerative Diseases”, Drug Discovery Today, Volume 24, Number 2, February 2 , 2019, https://doi.org/10.1016/j.drudis.2018.11.001
  28. Yang CB, Cai CZ, Song JX, Tan JQ, Iyaswamy A, Wu M.Y., Durairajan S.S.K., Chen L.L., Yue Z.Y., Li M.* & Lu J.H.*(2017) “NRBF2 regulates amyloid precursor protein C-terminal fragments (APP-CTFs) degradation via autophagy modulation”, Autophagy 2017,13:12, 2028-2040. http://dx.doi.org/10.1080/15548627.2017.1379633
  29. Chen LL, Wang YB, Song JX, Deng WK, Lu JH, Ma LL, Yang CB, Li M*, Xue Y.* (2017) “Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy”. Autophagy 2017, 13:11, 1969-1980. doi:10.1080/15548627.2017.1371393
  30. Lan TH, Xu DP, Huang MT, Song JX, Wu HL, Li M. *(2017) “Ginsenoside Rb1 prevents homocysteine-induced EPC dysfunction via VEGF/p38MAPK and SDF-1/CXCR4 activation”. Sci. Rep. 2017 Oct 12;7(1): 13061. doi:10.1038/s41598-017-13436-7
  31. Wang SF, Liu LF, Wu MY, Cai CZ, Su HX, Tan JQ, Lu JH*, Li M.* (2017) “Baicalein prevents 6-OHDA/Ascorbic acid-induced calcium-dependent dopaminergic neuronal cells death”, Sci. Rep. 2017, 16 August 2017; doi:10.1038/s41598-017-07142-7
  32. Ji FF, Luan HM, Huang YY, Cai ZW*, Li M.* (2017) “MS‑Based Metabolomics for the Investigation of Neuro‑Metabolic Changes Associated with BDE‑47 Exposure in C57BL/6 Mice”, J. Anal. Test. 2017, 1:233-244 doi: 10.1007/s41664-017-0026-4
  33. Durairajan SSK* †, Iyaswamy A, Shetty GS, Kammella AK, Malampati S, Shang WB, Yang CB, Song JX, Chung S, Huang JD, Ilango K, Li M.* (2017) “A modified formulation of Huang-lian-Jie-Tu Tang reduces memory impairments and β-Amyloid plaques in a triple transgenic mouse model of Alzheimer's disease”, Sci. Rep. 2017, 7 Article number: 6238, doi: 1.1.38/s41598-017-06217-9
  34. Wang ZY, Liu JY, Yang CB, Malampati S, Huang YY, Li MX, Li M *, Song JX.* (2017) “Neuroprotective natural products for the treatment of Parkinson’s disease by targeting the autophagy-lysosome pathway”, Phytother Res. 2017;31(8):1119-1127. doi:10.1002/ptr.5834
  35. Sreenivasmurthy GS, Liu JY, Song JX, Yang CB, Malampati S, Wang ZY, Huang YY, Li M. * (2017) “Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer's Disease”, Int. J. Mol. Sci. 2017 ;18(2). doi:10.3390/ijms18020272
  36. Durairajan SSK*, Chirasani VR, Shetty GS, Iyaswamy A, Malampati S, Song JX, Liu LF, Huang JD, Senapati S, Li M.* (2017) “Decrease in the Generation of Amyloid-β Due to Salvianolic Acid B by Modulating BACE1 Activity”, Cur. Alzhei.Res.2017;14(11):1229-1237.doi:10.2174/1567205014666170417103003
  37. Chua KK, Wong A, Kwan WL, Song JX, Chen LL, Chan LT, Bian ZX, Mok V*, Li M.* (2016) “A Pilot Randomized Controlled Trial of Chinese Medicine (Di-Tan Decoction) in Alzheimer's disease”. J. Alzheimer Dis. & Parkins. 2017. doi:10.1155/2017/1902708
  38. Wang SF, Cai CZ, Wu MY, Li M*, Lu JH.* (2016) “Autophagy modulators from traditional Chinese medicine: mechanisms and therapeutic potentials for cancer and neurodegenerative diseases”, J. Ethnopharma. 2016. doi: 10.1016/j.jep.2016.10.069. PMID:27793785
  39. Song JX, Zeng Y, Yu X, Lu JH, Liu LF, Xu Z, Liu LF, Huang YY,Chen LL,Durairajan Zhang HQ, ** Li M.*6“An novel TFEB activator promotes autophagy and lysosomal biogenesis in rat brain independent of mTOR inhibition”. Autophagy doi:10.1080/15548627.2016.1179404
  40. Nie S, Chong K, Li M.* (2016) “A study in general education: How a field trip for Chinese tea tasting motivates students’ learning”, Inter.J.Hum. Soc. Sci. & Edu.
  41. Klionsky DJ, (…),Li M, (…),Lu JH, (…), Song JX, (…), et al. 2016Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy 2016; 12(1):1-222.
  42. Liu LF, Song JX, Lu JH, Huang YY, Chen L L, Duriarajan SSK, Han QB, Li M.* (2015) “Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson’s disease”Sci. Rep. 2015; doi:10.1038/srep16862.
  43. Friedemann T, Li M, Fei J, Schumacher U, Song JX, Schröder S.* (2015)“Hypothesis driven screening of Chinese herbs for promoting neuroprotection”, Special Issue on “The Art and Science of Traditional Medicine” Part3: The Global Impact of Traditional Medicine. Science (Special issue), 2015; S69-71.
  44. Luan HM, Liu LF, Tang Z, Mok VCT, Li M,* Cai ZW.* (2015) “Elevated excretion of biopyrrin as a new marker for idiopathic Parkinson's disease”, Parkinsonism Relat. Disord. 2015; doi: http://dx.doi.org/10.1016/j.parkreldis.2015.09.009
  45. Chen L, Song JX, Luo YM, Li M,* Gao L.* (2015) “Individualized Traditional Chinese Medicine Treatment of Acute Stroke”, Science (Special Issue: Translational Medicine at Capital Medical University: Investigating Major Chronic Disease) 17 July, 2015; P68-71.
  46. Luan HM, Liu LF, Tang Z, Zhang MW, Chua KK, Song JX, Mok V, Li M.,* Cai Z.W.* (2015) “Comprehensive urinary metabolomic profiling and identification of potential noninvasive marker for idiopathic Parkinson's disease”, Sci. Rep.2015; doi:10.1038/srep13888
  47. Nie S, Chong K, Thadani RD, Li M.* (2015) “Lifestyle Changes through Chinese Medicine Education on Health Maintenance and Food Therapy among College Students”, Inter. J. Develop. Res. 2015; 5(6): 4762-4767.
  48. Chua KK, Wong A, Kwan WL, Song JX, Chen LL, Chan LT, Lu JH, Mok V,* Li M.* (2015) “The efficacy and safety of the Chinese herbal medicine Di-Tan Decoction on Alzheimer's disease: study protocol for a randomized controlled trial”, Trials 2015, 16:199. DOI: 10.1186/s13063-015-0716-z
  49. Li JJ, Chua KK, Li M.* (2015) “Constitutional Study of Parkinson’s Disease Patients Based on Traditional Chinese Medicine Pattern Differentiation”, Integra. Med. Inter. 2015; doi:10.1159/000369530.
  50. Luan HM, Liu LF, Meng N, Tang Z, Chua KK, Chen LL, Song JX, Mok V, Xie LX, Li M*, Cai ZW.* (2015) “LC-MS-based Urinary Metabolite Signatures in Idiopathic Parkinson's Disease”, J. Proteome Res. 2015; 14, 467-478.
  51. Chua KK, Chen LL, Liu LF, Duriarajan SSK, Lu JH, Li M.* (2014) “The Efficacy of Classical Chinese Medicine Formula Di-tan Decoction for Alzheimer's disease”, Chin. J. Integr. Med. 2014; DOI: 10.1007/s11655-013- 1346.
  52. Lu JH, He LQ, Wang QJ, Behrends C, Chait BT, Yamamura K, Friedman SL, Fiel MI, Li M, Yue ZY. (2014) “NRBF2 Regulates Autophagy and Prevents Liver Lesions Through Modulating Beclin 1/Atg14L-Linked Class III Phosphatidylinositol-3 Kinase Activity”, Nat. Commun. 2014; 5:3920.
  53. Chen LL, Song JX, Lu JH, Yuan ZW, Liu LF, Duriarajan SSK, Li M.* (2014) “Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-synuclein via Akt/mTOR Pathway”, J. Neuroimmune. Pharma. 2014; 9:380-387.
  54. Durairajan SSK*, Huang YY, Yuen PY, Chen LL, Kwok KY, Liu LF, Song JX, Han QB, Xue L, Chung SK, Huang JD, Baum L, Senapati S, Li M.* (2014)“Effects of Huanglian-Jie-Du-Tang and Its Modified Formula on the Modulation of Amyloid-beta Precursor Protein Processing in Alzheimer's Disease Models ”, PLoS ONE 2014; 3(9): e92954.
  55. Song JX, Lu JH, Liu LF, Chen LL, Durairajan SSK, Yue ZY, Zhang  HQ*, Li M.* (2014) “HMGB1 is Involved in Autophagy Inhibition Caused by Alpha-synuclein Overexpression: a Process Modulated by the Natural Autophagy Inducer Corynoxine B”, Autophagy. 2014; 10(1):144-154.
  56. Chua KK, Gao J, Kum WF, Li M.* (2013) “Impact of Treatment-related Dyskinesias and Non-motor Symptoms on Quality of Life in Chinese Patients with Idiopathic Parkinson's Disease”, Inter. J. Integra. Med. 2013; doi:10. 5772/56777
  57. Durairajan SSK, Liu LF, Lu JH, Chen LL, Yuan QJ, Chung SK, Huang L, Li XS, Huang JD, Li M.* (2012) “Berberine Ameliorates Beta-amyloid Pathology, Gliosis and Cognitive Impairment in an Alzheimer's Disease Transgenic Mouse Model”, Neurobiol. Aging 2012; 33: 2903-2919.
  58. Lu JH, Tan JQ, Durairajan SSK, Liu LF, Zhang ZH, Ma L, Shen HM, Chan HY*, Li M.* (2012) “Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy”, Autophagy. 2012; 8(1):98-108. (Erratum in Autophagy. 2012; 8(5): 864-866.)
  59. Man SC, Chan KW, Lu JH, Durairajan SSK, Liu LF, Li M. * (2012) “Systematic Review on the Safety and Efficacy of Herbal Medicine for the Treatment of Vascular Dementia”, Evid. Based Complement. Alternat. Med.  2012; DOI:10.1155/ecam/2012/426215.
  60. Liu LF, Durairajan SSK, Lu JH, Koo I, Li M. * (2011) “In Vitro Screening on Amyloid Precursor Protein Modulation of Plants used in Ayurvedic and Traditional Chinese Medicine for Memory Improvement”, J. Ethnopharmacol. 2011; doi:10.1016/j.jep.2011.08.065.
  61. Durairajan SSK, Liu LF, Lu JH, Koo I, Maruyama K, Chung S K, Huang JD*, Li M.* (2011) “Stimulation of Non-amyloidogenic Processing of Amyloid Precursor Protein by Cryptotanshinone Involves Activation and Translocation of ADAM-10 and PKC-alpha”, J. Alzheimer's Dis. 2011; 25: 245-262.
  62. Lu JH, Ardah MT, Durairajan SSK, Liu LF, Xie LX, Fong WF, Hasan MY, Huang JD, El-Agnaf MAO*, Li M.* (2011) “Baicalein Inhibits Formation of Alpha-synuclein Oligomers within Living Cells and Prevents Abeta Fibrillation and Oligomerization”, ChemBioChem. 2011;12:615-624.
  63. Kum WF, Durairajan SSK, Bian ZX, Lam YC, Man SC, Xie LX, Lu JH, Huang XZ, Li M.* (2011) “Treatment of Idiopathic Parkinson's Disease with Traditional Chinese Herbal Medicine: A Randomized Placebo-Controlled Pilot Clinical Study”, Evid. Based Complement. Alternat. Med. 2011;724353.
  64. Xie LX, Durairajan SSK, Lu JH, Liu CL, Kum WF, Wu WK, Han D, Liao FL, Huang JD, Li M.* (2010) “The Effect of Salvianolic acid B Combined with Laminar Shear Stress on TNF-alpha stimulated Adhesion Molecule Expression in Human Aortic Endothelial Cells”, Clin. Hemorhe. Mecro. 2010; 44:245-258.
  65. Chan WS, Durairajan SSK, Lu JH, Xie LX, Wang Y, Kum WF, Koo I, Yung KKL, Li M.* (2009) “The Neuroprotective Effects of Astragaloside IV (AS-IV) in 6-OHDA-treated Nigral Primary Cell Culture”, Neurochem. Int. 2009; 55: 414-422.
  66. Kum WF, Gao J, Durairajan SSK, Man SC, Xie LX, Lu JH, Fong WL, Li M.* (2009) “Risk Factors in Development of Motor Complications in Chinese Patients with Idiopathic Parkinson's disease”, J. Clin. Neurosci. 2009; 16: 1034-1037.  
  67. Lam YC, Kum WF, Lu JH, Durairajan SSK, Man SC, Xu M, Zhang XF, Huang XZ, Li M.* (2008) “Efficacy and Safety of Acupuncture for Idiopathic Parkinson's disease: A Systematic Review”, J. Altern. Complem. Med. 2008; 14(6): 663-671.
  68. Man SC, Durairajan SSK, Kum WF, Lu JH, Huang JD, Cheng CF, Chung V, Xu M, Li M. * (2008) “Systematic Review of the Efficacy and Safety of Herbal Medicines for Alzheimer's Disease”, J. Alzheimer's Dis. 2008; 14(2): 209-223.
  69. Li M*, Zhao MQ, Durairajan SSK, Xie LX, Zhang HX, Kum WF, Goto S, Liao FL. (2008) “Protective Effect of Tetramethylpyrazine and Salvianolic Acid B on Apoptosis of Rat Cerebral Microvascular Endothelial Cell under High Shear Stress”,  Clin. Hemorhe. Mecro. 2008; 38:177-187.
  70. Durairajan SSK, Yuan QJ, Xie LX, Chan WS, Kum WF, Koo I, Liu CL, Song YQ, Huang JD*, Klein WL, Li M.* (2008) “Salvianolic Acid B Inhibits Aβ Fibril Formation, Disaggregates Preformed Fibrils, and Protects Against Aβ-induced Cytotoxicity”, Neurochem. Int. 2008; 52: 741-750.
  71. Liu CL, Xie LX, Li M,* Kumar DSS, Goto S, Huang JD.* (2007) “Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through Regulating PI3K/Akt Signaling”, PLoS ONE 2007; doi:10.1371/journal.pone.0001321.2007.12.19
  72. Chung V, Liu L, Bian ZX, Zhao ZZ, Fong WL, Kum WF, Gao J, Li M.* (2006) “The Efficacy and Safety of Herbal Medicines for Idiopathic Parkinson's Disease: a Systematic Review”, Mov. Disord. 2006; 21: 1709-1715.
  73. Liao FL, Li M, Han D, Cao J, Chen KJ. (2006) “Biomechanopharmacology- a New Borderline Discipline”, Trends Pharmacol. Sci. 2006; 27:287-289.
  74. Li M,* Zhao C, Wong Ricky NS, Goto S, Wang ZM, Liao FL. (2004) “Inhibition of Shear-induced Platelet Aggregation in Rat by Tetramethylpyrazine and Salvianolic acid B”, Clin. Hemorheol. Microcirc.2004; 31:97-103.
  75. Li M,* Wu WK, Liu L, Liao FL, Handa S, Goto S. (2004) “Specific Inhibiting Effects of Ilexonin A on von Willebrand Factor-dependent Platelet Aggregation Under High Shear Rate”, Chin. Med. J.,(Eng.). 2004; 117: 241-246 .
  76. Li M,* Liu L, Zhang XH, Yeh ML, Liao FL. (2003) “Correlation between Shear Induced Platelet Aggregation and Viscosity Parameter for Platelet-rich Plasma”, Clin. Hemorheol Microcirc. 2003; 28:259-261.
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