曾少慧博士

  • 教學科研部研究助理教授
  • 胰腺炎, 糖尿病及癌症的病理機制; 小分子和中草藥化合物的藥物研發
  • tsang@hkbu.edu.hk

曾少慧博士於美國賓夕凡尼亞州州立大學取得生物技術學學士學位, 並在香港中文大學獲得生理學碩士學位及在香港大學獲得生化學博士學位. 畢業後, 她獲美國衛生署授予研究員獎學金, 在美國紐約州州立大學石溪分校擔任博士後研究員, 並於2010年加入香港浸會大學中醫藥學院. 曾博士現時主要集中研究胰腺炎, 糖尿病, 結腸炎及各種癌症的病理機制, 她的研究興趣亦包括小分子和中草藥化合物的藥物研發。

精選出版物

Tsang SW, Auyeung KK, Bian ZX, Ko JK*. Pathogenesis, experimental models and contemporary pharmacotherapy of irritable bowel syndrome: story about the brain-gut axis. Curr Neuropharmacol. 2016;14(8):842-856. 

Lin ZS, Ku CF, Guan YF, Xiao HT, Shi XK, Wang HQ, Bian ZX, Tsang SW*, Zhang HJ*. Dihydro-resveratrol ameliorates lung injury in rats with cerulein-induced acute pancreatitis. Phytother Res. 2016;30(4):663-70.

Tsang SW*, Guan YF, Wang J, Bian ZX, Zhang HJ*. Inhibition of pancreatic oxidative damage by stilbene derivative dihydro-resveratrol: implication for treatment of acute pancreatitis. Sci Rep. 2016;6:22859.

Xiao HT, Peng J, Hu DD, Lin CY, Du B, Tsang SW, Lin ZS, Zhang XJ, Lueng FP, Han QB, Bian ZX*. Qing-dai powder promotes recovery of colitis by inhibiting inflammatory responses of colonic macrophages in dextran sulfate sodium-treated mice. Chin Med. 2015;10:29.
 

Tsang SW*, Zhang HJ, Chen YG, Auyeung KK, Bian ZX*. Eruberin A, a natural flavanol glycoside, exerts anti-fibrotic action on pancreatic stellate cells. Cell Physiol Biochem. 2015;36(6):2433-46.

Lin Z, Zheng LC, Zhang HJ, Tsang SW*, Bian ZX*. Anti-fibrotic effects of phenolic compounds on pancreatic stellate cells. BMC Complement Altern Med. 2015 Jul 30;15:259.

Tsang SW*, Zhang HJ, Lin Z, Mu H, Bian ZX*. Anti-fibrotic effect of trans-resveratrol on pancreatic stellate cells. Biomed Pharmacother. 2015 Apr;71:91-7.

Xiao HT, Zhong L, Tsang SW, Lin ZS, Bian ZX. Traditional Chinese medicine formulas for irritable bowel syndrome: from ancient wisdoms to scientific understandings. Am J Chin Med. 2015;43(1):1-23.

Tsang SW, Ip SP, Wu JC, Ng SC, Yung KK, Bian ZX. A Chinese medicinal formulation ameliorates dextran sulfate sodium-induced experimental colitis by suppressing the activity of nuclear factor-kappaB signaling. J Ethnopharmacol. 2015 Mar 13;162:20-30.

Tsang SW, Bian ZX. Anti-fibrotic and anti-tumorigenic effects of rhein, a natural anthraquinone derivative, in mammalian stellate and carcinoma cells. Phytother Res. 2015 Mar;29(3):407-14.

Bian ZX, Tsang SW. Therapeutic implications of antioxidant defense in acute pancreatitis. Hepatobiliary Pancreat Dis Int. 2014 Aug;13(4):346-7.

Tsang SW, Zhang HJ, Lin C, Xiao H, Wong M, Shang H, Yang ZJ, Lu A, Yung KK, Bian ZX. Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis. PLoS One. 2013 Dec3;8(12):e82201.

Xiao HT, Lin CY, Ho DH, Peng J, Chen Y, Tsang SW, Wong M, Zhang XJ, Zhang M,Bian ZX. Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. J Nat Prod. 2013 Nov 22;76(11):2120-5.

Xiao HT, Tsang SW, Qin HY, Choi FF, Yang ZJ, Han QB, Chen HB, Xu HX, Shen H,Lu AP, Bian ZX. A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn. J Ethnopharmacol. 2013 Sep 16;149(2):499-505.

Tsang SW, Zhao M, Wu J, Sung JJ, Bian ZX. Nerve growth factor-mediated neuronal plasticity in spinal cord contributes to neonatal maternal separation-induced visceral hypersensitivity in rats. Eur J Pain. 2012 Apr;16(4):463-72.

Huang P, Yeku O, Zong H, Tsang SW, Su W, Yu X, Teng S, Osisami M, Kanaho Y, Pessin JE, Frohman MA. Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice. Diabetes. 2011 Feb;60(2):454-63.

Tsang SW, Shao D, Cheah KS, Okuse K, Leung PS, Yao KM. Increased basal insulin secretion in Pdzd2-deficient mice. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):263-70.

 

Patents

Method of using dihydro-resveratrol for treating acute pancreatitis and associated pulmonary injury, Patent #: US9526706 B1
Use of a flavanol glycoside for suppressing activation of stellate cells, Patent #: US 9260466 B2
Chinese medicinal formulation for treating inflammatory bowel disease and the preparation thereof
Patent #: US 9044502 B2
大黃酸在製備治療胰腺纖維化藥物中的應用, Patent #: CN 103505448 B 
Use of rhein in manufacturing a medicament for treating pancreatic fibrosis, HK standard patent #: 1189487
Method of using rhein for treating fibrotic conditions and tumors, Patent #: US 8652540 B2

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