余堅文博士

余堅文博士是生化學專家,專門從事糖尿病的研究,現時之主要研究範疇包括糖尿病併發症、糖尿病性血管病及遺傳因子轉移等。余博士一九八五年畢業於英國利物浦大學,一九八九年於同校獲生化學博士學位,其後在英國萊斯特大學及曼徹斯特大學從事博士後學人研究。加入香港浸會大學前,余博士為英國貝爾法斯特英皇大學醫學院臨床生物化學講師。現時,余博士於本院負責教授解剖學、生理學及生化學等科目。

鑒於對中醫藥的興趣日濃,余博士遂向有關方面深造,並於香港浸會大學獲中醫學學士學位。余博士現為註冊中醫師。中醫藥的訓練,有助余博士擴闊其研究領域至中藥及方劑對治療糖尿病併發症的應用,以及中藥的作用原理和機制。

精選出版物

  1. KM Lee, CY Lee, G Zhang, A Lyu and KKM Yue (2019). Methylglyoxal Activates Osteoclasts through JNK Pathway Leading to Osteoporosis. Chemico-Biological Interactions, 308, 147-154.
  2. N. Tso, C.Y. Lee, K.M. Lee, W.Y. Li, H.Y. Kwan and K.K.M. Yue (2019).  Panax Notoginseng Enhances Wound Healing Efficiency and Quality on diabetic rats. HSOA J. Alt, Compl & Int. Med. (in press)
  3. K Yue, KM Lee, CY Lee, G Zhang, A Lyu (2019). The Dataset of Methylglyoxal Activating p38 and p44/42 Pathway in Osteoclast. Data in Brief (in press).
  4. Kevin K Yue, Lisa Y Law, HL Chan, Jade B Chan, Elaine Y Wong, Theresa F Kwong, Eva Y Wong (2017). Enhancing Residential Student Leadership Training with Appropriate Augmented Reality M-Learning Trail Design. e-Book ‘IAmLearning: Mobilizing and Supporting Educator Practice’.  (Best Chapter Award)
  5. Theresa Kwong, Eva Y. W. Wong, Kevin K M Yue (2017). Bringing Abstract Academic Integrity and Ethical Concepts into Real-Life Situations. Technology, Knowledge, and Learning, 22(7), 1-16.
  6. Chu JM, Lee DK, Wong DP, Wong GT and Yue KK (2016). Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals. Metabolic Brain Diseases, 31 (5), 1055-1064.
  7. Guo H, Niu X, Gu Y, Lu C, Xiao C, Yue K, Zhang G, Pan X, Jiang M, Tan Y, Kong H, Liu Z, Xu G and Lu A (2016). Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern. International Journal of Molecular Sciences, 17 (10), E1757.
  8. Zhang, H.Q., Cheung, C.H., Tu, F., Huang, F.L., O, L., Song, L., Xu, G., Law, H., Chong, K. and Yue, K.K.M. (2016). Service Learning for Whole Person Education in Chinese Medicine Developed by a Community of Practice. Learning Communities Journal, 8 (2), 145-170.
  9. Cheung, S.Y., Yue, K.K., Kwong, T., Lau, P., Ng, A., Lo, Y., Yung, K., Chu, C., Siu, N., Choi, P., Ng, M. (2016). Using a Community of Practice to Enhance Students’ Graduate Attributes through Problem-based Learning. Learning Communities Journal, 8 (2), 71-92.
  10. Liu J, Dang L, Li D, Liang C, He X, Wu H, Qian A, Yang Z, Au DW, Chiang MW, Zhang BT, Han Q, Yue KK, Zhang H, Lv C, Pan X, Xu J, Bian Z, Shang P, Tan W, Liang Z, Guo B, Lu A, Zhang G (2015). A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts. Biomaterials, 52, 148-160.
  11. Liang C, Guo B, Wu H, Shao N, Li D, Liu J, Dang L, Wang C, Li H, Li S, Lau WK, Cao Y, Yang Z, Lu C, He X, Au DW, Pan X, Zhang BT, Lu C, Zhang H, Yue K.K, Qian A, Shang P, Xu J, Xiao L, Bian Z, Tan W, Liang Z, He F, Zhang L, Lu A, Zhang G (2015). Aptamer- functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nature Medicine, 21, 288-294.
  12. Chu, J.M., Lee, D.K., Wong, D..P, Wong, R.N., Yung, K.K., Cheng, C.H., Yue, K.K.M. (2014).  Ginsenosides attenuate methylglyoxal-induced impairment of insulin signaling and subsequent apoptosis in primary astrocytes.  Neuropharmacology, 85:215-23.
  13. Guo, B., Zhang, B., Zheng, L., Tang, T., Liu, J., Wu, H., Yang, Z., Peng, S., He, X., Zhang, H., Yue, K.K.M., He, F., Zhang, L., Qin, L., Bian, Z., Tan, W., Liang, Z., Lu, A., Zhang, G. (2014).  Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation. Bone, 59:76-88.
  14. Wong, D.P.K., Chu, J.M.T., Hung, V.K.L., Lee, D.K.M., Cheng, C.H.K., Yung, K.K.L. and Yue, K.K.M. (2013).  Modulation of Endoplasmic Reticulum Chaperone GRP78 by High Glucose in Hippocampus of Streptozotocin-induced Diabetic Mice and C6 Astrocytic Cells.  Neurochemistry International, 63(6):551-560.
  15. Chan, G.H.H., Law, B.Y.K., Chu, J.M.T., Yue, K.K.M., Jiang, Z.H., Lau, C.W., Chan, S.W., Yue, P.Y.T. and Wong, R.N.S. (2013).  Ginseng Extracts Restore High-gluocse Induced Vascular Dysfunctions by Altering Triglyceride Metabolism and Down-regulation of Atherosclerosis-related Genes.  Evidence-based Complementary and Alternative Medicine, 2013:797310.
  16. Cho, W.C.S., Yip, T-T., Chung, W-S., Lee, S.K.W., Leung, A.W.N., Cheng, C.H.K. and Yue, K.K.M. (2006).  Altered expression of serum protein in ginsenoside Re treated diabetic rats detected by SELDI-TOF MS.  Journal of Ethnopharmacology, 108, 272-279.
  17. Cho, W.C.S., Chung, W.S., Lee, S.K., Leung, A.W.N., Cheng, C.H.K. and Yue, K.K.M. (2006).  Ginsenoside Re of Panax ginseng possess significant antioxidant and antihyperlidemic efficacies in streptozotocin-induce diabetic rats.   European Journal of Pharmacology , 550, 173-9.
  18. Cho, W.C.S., Yip, T-T., Chung, W-S., Leung, A.W.N., Cheng, C.H.K. and Yue, K.K.M. (2006).  Differential expression of proteins in the kidney, eye, aorta and serum of diabetic and non-diabetic rats.  Journal of Cellular Biochemistry , 99, 256-268.
  19. Ha, W.Y., Li, X.J., Yue, P.Y.K., Wong, D.Y.L., Yue, K.K.M., Chung, W.S., Zhao, L., Leung, P.Y., Liu, L. and Wong, R.N.S. (2006).  Gene expression profiling of human synovial sarcoma cell line (Hs701.T) in response to IL-1 stimulation.  Inflammation Research,  55, 1-7.
  20. Yue, K.K.M., Lee, K.W., Leung, A.W.N., Chan, K.K.C., Leung, K.S.Y. and Cheng, C.H.K. (2006). Danshen prevents the occurrence of oxidative stress in eyes and aorta of diabetic rats.  Journal of Ethnopharmacology, 106, 136-141.
  21. Cho, WCS, Yip, TT, Chung, WS, Leung AWN, Cheng, CHK and Yue, K.K.M. (2006).  Potential biomarkers identified by proteomic profiling may provide insight for the macrovascular pathogenesis of diabetes mellitus.  Disease Markers , 22, 153-166.
  22. Yue, K.K.M., Leung, S.N., Man, P.M., Yeung, W.F., Chung, W.S., Lee, K.W., Leung, A.W.N. and Cheng, C.H.K. (2005).   Alterations in antioxidant enzyme activities in the eye, aorta and kidney of diabetic rats relevant to the onset of oxidative stress.  Life Sciences, 77, 721-34.
  23. Koon, H.K., Leung, A.W.N., Yue, K.K.M. and Mak, N.K. (2005).  Photodynamic effect of curcumin on NPC/CNE2 cells.  Journal of Enviromental Pathology, Toxicology & Oncology, 25, 1-11.
  24. Cho, WCS, Yue K.K.M and Leung A.W.N. (2005).  An outline of diabetes mellitus and its treatments by traditional Chinese medicine.  Journal of Chinese Medicine, 78, 29-37.
  25. Cho, W.C.S., Yue, K.K.M. and Leung, A.W.N. (2005).  Proteomics- Leading the postgenome era.  China Biotechnology, 25, 33-38.
  26. Cho, W.C.S., Yue, K.K.M. and Leung, A.W.N. (2004).  An outline of obesity and its therapy by Chinese and western medicine.  Chinese Journal of Traditional and Western Medicine, 24, 3073-3075.
  27. Yue, K.K.M., Chung, W.S., Leung, A.W.N. and Cheng, C.H.K. (2003).  Redox changes precede the occurrence of oxidative stress in eyes and aorta, but not in kidneys of diabetic rats.  Life Sciences, 73, 2557-2570.
  28. Sharpe, P.C., Yue, K.K.M., McMaster, D, Catherwood, M.A., Trimble, E.R. (1998).  The Role of Glucose-Induced Oxidative Stress on Growth and Extracellular Matrix Gene Expression of Vascular Smooth Muscle Cells.  Diabetologia, 41, 1210-1219.
  29. Sharpe, P.C., Liu, W.H., Yue, K.K.M., McMaster, D, Catherwood, M.A., McGuinty, A., Trimble, E.R. (1998).  Glucose-Induced Oxidative Stress in Vascular Contractile Cells: Comparison of Aortic Vascular Smooth Muscle Cells and Retinal Capillary Pericytes.  Diabetes, 47, 801-809.
  30. Chidgey, M.A.J., Yue, K.K.M., Gould, S, Byrne, C., Garrod, D.R. (1997).  Changing Pattern of Desmocollin 3 Expression Accompanies Epidermal Organisation During Skin Development. Developmental Dynamics, 210, 315-327.
  31. Sharpe, P.C., Yue, K.K.M., Catherwood, M.A., McMaster, D., Trimble, E.R. (1996).  Glucose- induced Oxidative Stress in Vascular Smooth Muscle Cells.  Diabetologia, 39, 1078-1078.
  32. Yue, K.K.M., Holton, J.L., Clarke., J.P., Hyam, J.I.M., Hashimoto, T., Chidgey, M.A.J., Garrod, D.R. (1995). Characterisation of a Desmocollin Isoform (Bovine DSC3) Exclusively Expressed in the Lower Layers of Stratified Epithelia. Journal of Cell Science, 108, 2163-2173.
  33. Hashimoto T, Amagai M, Watanabe K, Dmochowski M, Chidgey MA, Yue KK, Garrod DR, Nishikawa T. (1995). A case of pemphigus vulgaris showing reactivity with pemphigus antigens (Dsg1 and Dsg3) and desmocollins. Journal of Investigative Dermatology, 104(4), 541-544.
  34. Dmochowski M, Hashimoto T, Chidgey MA, Yue KK, Wilkinson RW, Nishikawa T, Garrod DR. (1995). Demonstration of antibodies to bovine desmocollin isoforms in certain pemphigus sera. British Journal of Dermatology, 133(4), 519-525.
  35. Legan, P.K., Yue, K.K.M., Chidgey, M.A.J., Holton, J.L., Wilkinson, R.W., Garrod, D.R. (1994). The Bovine Desmocollin Family: A New Gene and Expression Patterns Reflecting Epithelial Cell Proliferation and Differentiation. Journal of Cell Biology, 126, 507-518.
  36. Holland IB, Possot O, Blight M, Yue K. (1991). Bacterial haemolysin and mammalian P-glycoprotein. Biochemical Society Transaction, 19(2), 252-255.
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