王凱亮博士

王凱亮博士分別於2009年和2013年在香港大學獲得生物化學學士學位和博士學位,畢業後在香港大學生物醫學學院從事研究工作,並於2016年加入香港浸會大學中醫藥學院擔任研究助理教授。

王博士致力於探索細胞外基質及膜型基質金屬蛋白酶在發育過程中的調節機制,並揭示了MT1-MMP在多種信號通路調節中的主導作用。他還集中研究幹細胞在發育過程和疾病中的重要性,分別在Nature Communications、Developmental Cell、The EMBO Journal、 Cell Cycle等國際著名的核心期刊上發表了研究論文和評論文章。

主要研究:

  1. 細胞外基質在發育過程和疾病中的調節機制
  2. 幹細胞自我更新和分化在發育和疾病中的重要性
  3. 中藥化合物抗衰老的作用

精選出版物

  1. Wong HLX, Qin H, Tsang SW, Zuo X, Che S, Zhao L, Huang T, Lin CY, Kwan HY, Lyu A, Bian Z (2019) Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Communications 10(1):1745 [Impact factor:12.383 in 2018]
  2. Fatima S, Hu X, Gong RH, Huang C, Chen M, Wong HLX, Bian Z, Kwan HY (2019) Palmitic acid is an intracellular signaling molecule involved in disease development. Cellular and Molecular Life Science [Impact factor: 6.721 in 2018]
  3. Zhao L, Huang Y, Lu L, Yang W, Huang T, Lin Z, Lin CY, Kwan HY, Wong HLX, Chen Y, Sun S, Xie X, Fang X, Yang H, Wang J, Zhu L, Bian Z (2018) Saturated long-chain fatty acid-producing bacteria contributes to enhanced colonic motility in rats. Microbiome 2018;6(1):107. [Impact factor:9.133 in 2018]
  4. Wong HLX, Jin G, Zhang S, Cao R, Cao Y, Zhou Z (2016) MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis. Nature Communications 7:10824 [Impact factor: 12.124 in 2016]
  5. Chan KM*, Wong HLX* (*co-first), Jin G, Liu B, Cao R, Cao Y, Lehtl K, Tryggvason K and Zhou Z (2012). MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling in calvarial osteogenesis. Developmental Cell, 22(6); 1176-1190 [Impact factor: 12.861 in 2012] 
    [recommended in F1000 Prime, F1000 factor 8.0]
  6. Wong HLX, Cao R, Chan KM, Jin G, Cao Y, Zhou Z (2012). When MT1-MMP Meets ADAMs. Cell Cycle, 11 [Impact factor:5.243 in 2012]
  7. Wong HLX, Zhou Z (2012) The Functional Crosstalk between MT1-MMP and ADAMs (2012) Biochemistry & Analytical Biochemistry (invited editorial) [Journal Impact factor:2.63]
  8. Jin G, Zhang F, Chan KM, Wong HLX, Liu B, Cheah KSE, Liu X, Mauch C, Liu D, Zhou Z (2011). MT1-MMP cleaves Dll1 to negatively regulate Notch signaling to maintain normal B-cell development. EMBO J., 30: 2281-2293 [Impact factor:9.205 in 2011]
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