周立敏博士

周立敏博士1993年獲瀋陽藥科大學藥學學士學位,1999年獲日本千葉大學製劑工學碩士學位,2008年獲香港中文大學藥劑學院生物藥劑學博士學位。周博士的研究領域主要是藥物緩、控釋製劑的研發、中藥活性成分的生物藥劑學及藥物代謝動力學研究以及中西藥的相互作用。2016年9月獲聘為持續及專業教育部一級講師,現從事中藥藥劑學、藥事管理學等相關學科的教學工作。

精選出版物

Book Chapter:

  1. Zhong Zuo, Li Zhang, Limin Zhou. Intestinal absorption and disposition of Green Tea catechins: The first barrier for Green Tea catechins entering the body. In: TEA in Health and Disease Prevention. Edited by Victor R. Preedy. Publisher: Elsevier Inc. 2012, pp. 399-412

Journal papers:

  1. Wang Y, Li M, Qian S, Zhang Q, Zhou L, Zuo Z, Lee B, Toh M, Ho T. Zolpidem Mucoadhesive Formulations for Intranasal Delivery: Characterization, In Vitro Permeability, Pharmacokinetics, and Nasal Ciliotoxicity in Rats. J Pharm Sci. 105(9):2840-2847 (2016).
  2. Zhang X, Ng HL, Lu A, Lin C, Zhou L, Lin G, Zhang Y, Yang Z, Zhang H. Drug delivery system targeting advanced hepatocellular carcinoma: Current and future. Nanomedicine. 12(4):853-869 (2016).
  3. Fong SY, Zhang Y, Wong YC, Zhou L, Han Q, Zuo Z. Identification and sitidispoon of novel mono-hydroxyl mefenamic acid and their potentially toxic 1-O-acyl-glucuronides in vivo. Biopharm Drug Dispos. 36(8): 529-551 (2015).
  4. Zhang Z, Ge B, Zhou L, Lam TN, Zuo Z. Induction of liver cytochrome P450s by Danshen-Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin. J Ethnopharmacol. 154(3):672-86 (2014).
  5. Zhou L, Wang S, Zhang Z, San Lau B, Pui Fung K, Chung Leung P, Zuo Z. Pharmacokinetic and pharmacodynamic interaction of Danshen-Gegen extract with warfarin and aspirin. J Ethnopharmacol. 143(2): 48-55 (2012).
  6. Li C, Zhang L, Zhou L, Wo SK, Lin G, Zuo Z. Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae. AAPS J. 14(1): 3-34 (2012).
  7. Fong YK, Li CR, Wo SK, Wang S, Zhou L, Zhang L, Lin G, Zuo Z. In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of Baicalein. J Ethnopharmacol. 141(2): 742-53 (2012).
  8. Zuo Z, Wo SK, Lo CM, Zhou L, Cheng G, You JH. Simultaneous measurement of S-warfarin, R-warfarin, S-7-hydroxywarfarin and R-7-hydroxywarfarin in human plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 52 (2): 305-310 (2010).
  9. Zhou L, Chow M, Zuo Z. Effect of sodium caprate on the intestinal absorption and oral bioavailabilities of danshensu and salvianolic acid B, the major hydrophilic active components in Saliva miltiorrhiza Bge. Int. J. Pharm. 379 (1): 109-118 (2009).
  10. Li C, Zhou L, Lin G, Zuo Z. Contents of major bioactive flavones in proprietary Traditional Chinese Medicine products and reference herb of Radix Scutellariae. J Pharm Biomed Anal. 50 (3): 298-306 (2009)
  11. You JH, Zuo Z, Lo CM, Zhou L, Yiu HH, Chau CT, Choi KC, Choi DK, Wong RS, Cheng G. Any effect of CYP2C9 variants on warfarin clearance in Chinese patients? Thromb Haemost. 97(5): 866-868 (2007).
  12. Zuo Z, Zhang L, Zhou L, Chang Q, Chow M. Intestinal absorption of hawthorn flavonoids--in vitro, in situ and in vivo correlations. Life Sci. 79(26): 2455-2462 (2006).
  13. Zhou L, Chow M, Zuo Z. Improved quality control method for Danshen products-Consideration of both hydrophilic and lipophilic active components.  J Pharm Biomed Anal. 41(3): 744-750 (2006).
  14. Zhou L, Zuo Z, Chow MS. Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J. Clin. Pharmcol. 45: 1345-1359 (2005).
  15. L.M. Zhou, J. Sirithunyalug, E. Yonemochi, T. Oguchi and K. Yamamoto: Complex Formation between Erythritol and 4-Hexylresorcinol. Journal of Thermal Analysis and Calorimetry. 59: 951-960 (2000) 
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