呂愛平教授

  • 中醫藥學院院長;黃英豪博士中醫藥教授;岑堯寬岑碧泉紀念癌症炎症研究中心主任;整合生物信息醫學與轉化科學研究所所長;香港浸會大學疼痛聯合研究中心主任;歐洲科學院外籍院士
  • 中醫藥、臨床藥理與關節類及相關新藥研發專家
  • aipinglu@hkbu.edu.hk

呂愛平,香港浸會大學中醫藥學院院長、講座教授,香港浸會大學岑堯寬岑碧泉紀念癌症炎症研究中心主任、香港浸會大學整合生物信息醫學和轉化科學研究所所長、香港浸會大學疼痛聯合研究中心主任、中國中醫科學院首席研究員。是國家杰出青年基金獲得者。是國家自然科學基金委員會醫學部諮詢委員會委員, 國家藥典委員會委員,全國科學技術名詞審定委員會中醫名詞術語委員會副主任委員, 國際標准化組織-TC249 中方Mirror Committee 主席。最近更獲選為選為歐洲人文和自然科學院外籍院士。曾任中國中醫科學院臨床基礎研究所常務副所長(法人代表)、中國中醫研究院基礎理論研究所所長、江西本草天工科技有限公司(中藥固體制劑製造技術國家工程研究中心)董事長。

長期從事中醫證候分類治療類風濕關節炎的基礎和新藥研發工作。曾獲衛生部有突出貢獻中青年獎和中國標準突出貢獻獎。發表學術論文500 餘篇,其中包括Nature Medicine, Biomaterials, Briefings in Bioinformatics, Clinical Pharmacology and Therapeutics, Scientific Reports, Journal of Proteomic Research 等 SCI 收錄論文近200 篇。獲PCT和國家發明專利60 余項。編寫著作30 餘部。先後在Ohio State University、Lund University、香港科技大學和香港理工大學做訪問學者,多次受邀在國際學術會議上做特邀報告。

精選出版物

Representative Publications:

  • DDInter: an online drug-drug interaction database towards improving clinical decision-making and patient safety. Nucleic Acids Res. 2021 Oct 11:gkab880. doi: 10.1093/nar/gkab880
  • Exosomal transfer of osteoclast-derived miRNAs to chondrocytes contributes to osteoarthritis progression. Nature Aging, 2021 Apr 15;1, 368-384.doi.org/10.1038/s43587-021-00050-6
  • Improving structure-based virtual screening performance via learning from scoring function components. Brief Bioinform. 2021 May 20;22(3):bbaa094. doi: 10.1093/bib/bbaa094
  • Identifying Transcription factor combinations to modulate circadian rhythms by leveraging virtual knockouts on transcription networks. iScience. 2020 Aug 22;23(9):101490. doi: 10.1016/j.isci.2020.101490
  • Imperatorin and β-sitosterol have synergistic activities in alleviating collagen-induced arthritis. J Leukoc Biol. 2020 Aug;108(2):509-517. doi: 10.1002/JLB.3MA0320-440RR
  • HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis. Nat Commun. 2019 Oct 8;10(1):4579. doi: 10.1038/s41467-019-12163-z
  • Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial. Chin Med. 2019 Aug 2;14:26. doi: 10.1186/s13020-019-0247-8.
  • Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis. EBioMedicine. 2019 Mar; 41:538-555. doi: 0.1016/j.ebiom.2019.02.009
  • Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis. Nat Commun. 2018 Aug 24;9(1):3428
  • Dual-ligand modified liposomes provide effective local targeted delivery of lung-cancer drug by antibody and tumor lineage-homing cell-penetrating peptide. Drug Deliv. 2018 Nov;25(1):256-266
  • A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer. Nat Commun. 2017;8(1)
  • A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration. J Cachexia Sarcopenia Muscle. 2018 Jun;9(3):613-626
  • Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun. 2016 Mar 7;7:10872.
  • A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts. Biomaterials. 2015 Jun;52:148-60. doi: 10.1016/j.biomaterials.2015.02.007.
  • Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat Med. 2015 Mar;21(3):288-94. doi: 10.1038/nm.3791.
  • Identification of Characteristic Autoantibodies Associated With Deficiency Pattern in Traditional Chinese Medicine of Rheumatoid Arthritis Using Protein Chips. Front Pharmacol. 2019 Jul 10;10:755. doi: 10.3389/fphar.2019.00755
  • An integrative method to decode regulatory logics in gene transcription. Nat Commun. 2017;8(1)
  • Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial. Sci Rep. 2015 Apr 15;5:9700. doi:10.1038/srep09700.
  • The Crosstalk of Pathways Involved in Immune Response Maybe the Shared Molecular Basis of Rheumatoid Arthritis and Type 2 Diabetes. PLoS One. 2015 Aug 7;10(8):e0134990. doi: 10.1371/journal.pone.0134990.
  • Serum metabolic signatures of four types of human arthritis. J Proteome Res. 2013 Aug 2; 12 (8): 3769-79.
  • Expert consensus on the treatment of rheumatoid arthritis with Chinese patent medicines. J Altern Complement Med. 2013; 19(2):111-118.
  • Comparison of toxic reaction of Tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats. J Ethnopharmacol. 2011; 135(2):270-277.
  • Cold and heat pattern of rheumatoid arthritis in traditional Chinese medicine: distinct molecular signatures indentified by microarray expression profiles in CD4-positive T cell. Rheumatol Int. 2010 Jul 25.
  • The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen induced arthritis. Planta Medica.2006; 72,1268-1272.
  • Circadian rhythms on hypothalamic–pituitary–adrenal axis hormones and cytokines of collagen induced arthritis in rats. J Autoimmun. 2004; 22(4):277-85.
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