Prof BIAN Zhaoxiang

Prof Bian Zhaoxiang had been educated in Nanjing University of Traditional Chinese Medicine (TCM), Beijing University of Traditional Chinese Medicine and Pharmacology and Guangzhou University of TCM, and was conferred the Ph.D. degree in Integrated Chinese and Western Medicine in 1994. After graduation, he engaged in clinical and basic research in digestive diseases in Guangzhou University of TCM. Under the Quality Migrant Admission Scheme of HKSAR, he moved to Hong Kong Baptist University in 2001. Prof Bian's research focuses mainly on the relationship between psychological stress and digestive diseases, especially focusing on the development and recurrence of irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and colorectal cancer. Major research topics involve: i) Basic mechanism of visceral hyperalgesia and gastrointestinal motility disorder and its associated depression; 2) Psychological stress and colorectal cancer; 3) Clinical trial with Chinese medicine for digestive diseases, including IBS, IBD, functional constipation and colorectal cancer ; 4). New drug development based on Chinese herbal medicine and its active fraction for digestive diseases. He has been awarded second prize of National Science and Technology Award of China in 1999. Currently, Prof Bian serves as Director of Clinical Division, School of Chinese Medicine, and Associate Vice-President of HKBU.

Selected Publications

Selected publications ( 5 Theses; 14 Book Chapters; Total citation: 998; h-index: 18)

Part I: Experimental researches:

  1. Zhu GY, Wong BCK, Wong I, Bian ZX, Fong WF, Yang ZJ. Alkylphenols from the roots of Ardisia brevicaulis induce cell cycle arrest and apoptosis through endoplasmic reticulum stress pathway in human non-small-cell lung cancer cells, Chem Pharm Bull (Tokyo)., 2012, 60(8): 1029-36.
  2. Bian ZX*. Novel insights about the mechanism of visceral hypersensitivity in maternally separated rats. Neurogastroent & Motil, 2012; 24(7): 593-6.
  3. Liao W, Wei H, Wang X, Qiu Y, Gou X, Zhang X, Zhou M, Wu J, Wu T, Kou F, Zhang Y, Bian ZX, Xie G, Jia W. Metabonomic Variations Associated with AOM-induced Precancerous Colorectal Lesions and Resveratrol Treatment. J Proteome Res., 2012, 11 (6): 3436–3448.
  4. Zhang XJ, Choi FFK, Yan Z, Leung FP, Tan S, Lin SH, Xu HX, Jia W, Sung JJY, Cai ZW, Bian ZX*. Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics. FEBS J., 2012, 279: 2322–2331.
  5. Qin HY, Xiao HT, Leung FP, Wu JCY, Sung JJY, Xu HX, Tong XD, Bian ZX*. JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced post-inflammatory irritable bowel syndrome rats through reducing colonic EC cell hyperplasia and serotonin availability. Evid.-based Complement Altern. Med., 2012; 239638. Epub 2012 Jun 10.
  6. Zhang XJ, Leung FP, Hsiao WWL, Tan S, Li S, Xu HX, Sung JJY, Bian ZX*. Proteome profiling of spinal cord and DRG in rats with TNBS-induced colitis. World J Gastroenterol, 2012, 18(23): 2914-28.
  7. Qin HY, Xiao HT, WU JCY, Berman BM, Sung JJ, Bian ZX*. Key factors in developing TNBS-induced Post-inflammatory Irritable Bowel Syndrome Model in Rats. World J Gastroenterol, 2012,18(20): 2481-92.
  8. Tian XY, Wong WT, Sayed N, Luo J, Tsang SY, Bian ZX, Lu Y, Cheang WS, Yao X, Chen ZY, Huang Y. NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel. Pharmacol Res., 2012: 65(2): 239-46.
  9. Tsang SW, Bian ZX*, Zhang XJ, Zhao M. Nerve growth factor-mediated neuronal plasticity in spinal cord contributes to neonatal maternal separation-induced visceral hypersensitivity in rats. Eur J Pain., 2012: 16(4): 463-72.
  10. Bian ZX*, Qin HY, Tian SL, Qi SD. Combined effect of early life stress and acute stress on colonic sensory and motor responses through serotonin pathways: differences between proximal and distal colon in rats. Stress, 2011, 14(4): 448-58.
  11. Lin SH, Yang Z, Zhang XJ, Bian ZX, Cai ZW. Hippocampal metabolomics reveals 2, 3, 7, 8-tetrachlorodibenzo -p-dioxin toxicity associated with ageing in SD rats. Talanta, 2011, 85(2): 1007-12.
  12. Luo JL, Qin HY, Wong CK, Tsang SY, Huang Y, Bian ZX*. Enhanced Excitability and Down-Regulated Voltage-Gated Potassium Channels in Colonic DRG Neurons from Neonatal Maternal Separation Rats. J Pain., 2011, 12(5): 600-9.
  13. Lau YT, Wong CK, Luo J, Leung LH, Tsang PF, Bian ZX, Tsang SY. Effects of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers on the proliferation and cell cycle progression of embryonic stem cells. Pflugers Arch., 2011, 461(1):191-202.
  14. Qin HY, Tian XL, Wu J, Sung JJ, Xu HX, Bian ZX*. Systematic review of animal models of post-infectious/post inflammatory irritable. J Gastroenterol., 2011, 46: 164-174.
  15. Qin HY, Luo JL, Qi SD, Xu HX, Sung JJY, Bian ZX*. Visceral hypersensitivity induced by activation of Transient Receptor Potential Vanilloid Type 1 is mediated through the serotonin pathway in rat colon. Eur J Pharmacol, 2010 Nov 25, 647(1-3):75-83. Epub 2010 Sep 6.
  16. Ng SY, Chin CH, Lau YT, Luo J, Wong CK, Bian ZX, Tsang SY. Role of voltage-gated potassium channels in the fate determination of embryonic stem cells. J Cell Physiol., 2010, 224(1): 165-77.
  17. Zhang M, Leung FP, Huang Y, Bian ZX*. Increased colonic motility in a rat model of irritable bowel syndrome is associated with up-regulation of L-type calcium channels in colonic smooth muscle cells. Neurogastroent & Motil, 2010, 22(5): 162-70.
  18. Bian ZX*, Zhang M, Hang QB, Xu HX, Sung JJY. Analgesic effects of JCM-16021 on neonatal maternal separation-induced visceral pain in rats. World J Gastroenterol, 2010, 16(7): 837-845.                                                                         
  19. Zhang XJ, Chen HL, Li Z, Zhang HQ, Xu HX, Sung JJ, Bian ZX*. Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A(1) receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway. Pharmacol Biochem Behav, 2009, 94(1): 88-97.
  20. Chen HL, Zhang XJ, Qi SD, Xu HX, Sung JJ, Bian ZX*. Simultaneous determination of glutamate and aspartate in rat periaqueductal gray matter microdialysates by capillary electrophoresis with laser-induced fluorescence. J Chromatogr B Analyt Technol Biomed Life Sci, 2009, 877(27): 3248-52
  21. Chung EK, Bian ZX*, Xu HX, Sung JJ. Neonatal Maternal Separation Increases Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B Expression in the Descending Pain Modulatory System. Neurosignals, 2009, 17(3): 213-221.
  22. Bian ZX*, Li Z, Huang ZX, Zhang M, Chen HL, Xu HX, Sung JJ. Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients. J Gastroenterol, 2009, 44(7):666-74.
  23. Li Z, Zhang XJ, Xu HX, Sung JJ, Bian ZX*. Intracolonical administration of protease-activated receptor-2 agonists produced visceral hyperalgesia by up-regulating serotonin in the colon of rats. Eur J Pharmacol., 2009, 606(1-3): 199-204.
  24. Qi SD, Tian SL, Xu HX, Sung JJ, Bian ZX*. Quantification of luminally released serotonin in rat proximal colon by capillary electrophoresis with laser-induced fluorescence detection. Anal Bioanal Chem., 2009, 393(8): 2059-66.
  25. Zhang XJ, Li Z, Chung EKY, Zhang HQ, Xu HX, Sung JJY, Bian ZX*. Activation of Extracellular signal-regulated protein kinase is associated with colorectal distension-induced spinal and supraspinal neuronal response and neonatal maternal separation-induced visceral hyperalgesia in rats. J Mol Neurosci., 2009, 37(3): 274-287.
  26. Zhang XJ, Li Z, Leung WM, Liu L, Xu HX, Bian ZX*. The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats. J Pain., 2008, 9: 497-505.
  27. Chung EK, Zhang XJ, Xu HX, Sung JJ, Bian ZX*. Visceral hyperalgesia induced by neonatal maternal separation is associated with nerve growth factor-mediated central neuronal plasticity in rat spinal cord. Neuroscience, 2007, 149: 685-95.
  28. Chung EK, Zhang XJ, Li Z, Zhang HQ, Xu HX, Bian ZX*. Neonatal maternal separation enhances central sensitivity to noxious colorectal distention in rat. Brain Res., 2007, 1153: 68-77.
  29. Tian XY, Bian ZX*, Hu XG, Zhang XJ, Liu L, Zhang HQ. Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway. Brain Res, 2006, 1088:101-8.
  30. Bian ZX*, Zhang GS, Wong KL, Hu XG, Liu L, Yang ZJ, Li M. Inhibitory effects of magnolol on distal colon of guinea pig in vitro. Biol Pharm Bull., 2006, 29: 790-5.

Part II: Clinical researches:

  1. Zhong LL, Bian ZX, Gu JH, Zhou X, Tian Y, Mao JC, Chen XJ. Chinese Herbal Medicine (Zi Shen Qing) for Mild-to-Moderate Systematic Lupus Erythematosus: A Pilot Prospective, Single-Blinded, Randomized Controlled Study. Evid Based Complement Alternat Med. 2013;2013:327245. doi: 10.1155/2013/327245. Epub 2013 May 8.
  2. Cheng CW, Fu SF, Zhou QH, Wu TX, Shang HC, Tang XD, Liu ZS, Liu J, Lin ZX, Lao L, Lü AP, Zhang BL, Liu BY, Bian ZX*. Extending the CONSORT Statement to moxibustion. J Integr Med, 2013, 11(1): 54-63.
  3. Lu AP, Bian ZX, Chen KJ. Bridging the traditional Chinese medicine pattern classification and biomedical disease diagnosis with systems biology. Chinese J Integrative Med., 2012, 18(12): 883-90. Epub 2012 Dec 13.
  4. Cheng CW, Kwok AOL, Bian ZX, Tse DMW. A Cross Sectional Study of Constipation and Laxatives Use in Advanced Cancer Patients: Insights for Revision of Current Practice. Support care Cancer, 2013, 21(1): 149-56. Epub 2012 Jun.
  5. Cheng CW, Kwok AO, Bian ZX*, Tse DMW*. The Quintessence of Traditional Chinese Medicine: Syndrome and Its Distribution among Advanced Cancer Patients with Constipation, Evid.-based Complement Altern. Med., 2012; 739642. Epub 2012 Jun 24.
  6. Bian ZX*; Chen SL*, Chung CW, Wang J, Xiao HT, Qin HY. Developing new drugs from annals of Chinese medicine. Acta Pharmaceutica Sinica B., 2012, 2(1): 1-7.
  7. Zeng XX, Bian ZX*, Wu TX, Fu SF, Ziea E, Woon WT. Traditional Chinese Medicine Syndrome Distribution in Chronic Hepatitis B Populations: A Systematic Review. Am J Chin Med., 2011, 39(6): 1061-1074.
  8. Bian ZX*, Shang HC. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med., 2011, Feb 15, 154(4):290-1.
  9. Bian ZX*, Chang YH, Revised STRICTA as a extending the CONSORT Statement: More items should be involved in the checklist. J Altern Complem Med., 2011, 17(2): 97-8.
  10. Cheng CW, Bian ZX*, Zhu LX, Wu JC, Sung JJ. Efficacy of a Chinese herbal proprietary medicine (Hemp Seed Pill) for functional constipation. Am J Gastroenterol., 2011, 106(1):120-9.
  11. Bian ZX*, Cheung CW, Fan Y. Evidence-based Management of Herb-Drug Interaction in Cancer Chemotherapy, Explore (NY., 2010, 6(5): 324-9.
  12. Wang L, Cui X, Cheng L, Yuan Q, Li T, Li Y, Deng S, Shang H, Bian ZX. Adverse events to Houttuynia injection: A systematic review. J Evid Based Med., 2010, 3(3): 168-76.
  13. Bian ZX*. Wu TX. Legislation for trial registration and data transparency. Trials 2010, 11:64.
  14. Bian ZX, Tian HY, Gao L, Shang HC, Wu TX, Li YP, Zhang BL, Song L. Improving reporting of adverse events and adverse drug reactions following injections of Chinese materia medica, J Evid Based Med., 2010, 5-10.
  15. Wu TX, Shang HC, Bian ZX, Zhang JH, Li TQ, Li YP, Zhang BL. Recommendations for reporting adverse drug reactions and adverse events of traditional Chinese medicine. J Evid Based Med., 2010, 11-17.
  16. Bian ZX*, Shang HC, Wu TX, Li YP, Zhang BL. Review of adverse reactions to Chinese medicine injections. J Evid Based Med., 2010: 88-94.
  17. Cheng CW, Bian ZX*, Wu TX. Systematic review of Chinese herbal medicine for functional constipation. World J Gastroenterol, 2009, 15(39): 4886-95.
  18. Wu TX, Li YP, Bian ZX, Liu GJ, Moher D. Randomized trials published in some Chinese journals: how many are randomized? Trials, 2009, 10: 46.
  19. Cheng CW, Bian ZX*. How can apples be mixed with oranges? Explore (NY), 2008, 4(6): 379.
  20. Bian ZX*, Moher D, Li YP, Wu TX, Dagenais S, Cheng CW, Li J, Li TQ. Appropriately selecting and concisely reporting the outcome measures of randomized controlled trials of traditional Chinese medicine (CONSORT for TCM). J Chin Integr Med., 2008, 6: 771-5.
  21. Cheng CW, Bian ZX*, Li YP, Moher D, Wu TX, Dagenais S, Li J, Li TQ. Transparently reporting adverse effects of Traditional Chinese Medicine interventions in randomized controlled trials. J Chin Integr Med., 2008, 6: 881-6.
  22. Bian ZX*, Moher D. Clinical Studies and randomized controlled trials in Chinese herbal medicine: A historical and contemporary review. Thieme Almanac, 2008, 5-17.
  23. Bian ZX*, Moher D, Li YP, Wu TX, Dagenais S, Cheng CW, Li J, Li TQ. Precise reporting of traditional Chinese medicine interventions in randomized controlled trials. J Chin Integr Med., 2008, 6: 441-447.
  24. Wu TX, Li YP, Bian ZX, Li TQ, Li J, Dagenais S, Moher D for the CONSORT for TCM group. Consolidated standards for reporting trials of traditional Chinese medicine (CONSORT for TCM). Chin J Evid-based Med., 2007, 7,625-630.
  25. Bian ZX*. Stratification by sex and subgroup is necessary for RCT on IBS. Gut, 2006, 55: 743-4.
  26. Bian ZX*, Moher D, Dagenais S, Li YP, Wu TX, Liu L, Miao JX, Song L, Zhang HM. Improving the quality of randomized controlled trials in Chinese herbal medicine, part IV: applying a revised CONSORT checklist to measure reporting quality. J Chin Integr Med., 2006, 4: 233-42.
  27. Leung KS, Bian ZX*, Moher D, Dagenais S, Li YP, Liu L, Wu TX, Miao JX. Improving the quality of randomized controlled trials in Chinese herbal medicine, part III: quality control of Chinese herbal medicine used in randomized controlled trials. J Chin Integr Med., 2006, 4: 225-32.
  28. Bian ZX*, Moher D, Dagenais S, Li YP, Liu L, Wu TX, Miao JX. Improving the quality of randomized controlled trials in Chinese herbal medicine, part II: control group design. J Chin Integr Med., 2006, 4: 130-6.
  29. Bian ZX*, Li YP, Moher D, Dagenais S, Liu L, Wu TX, Miao JX, Kwan AK, Song L. Improving the quality of randomized controlled trials in Chinese herbal medicine, part I: clinical trial design and methodology. J Chin Integr Med., 2006, 4: 120-9.
  30. Bian ZX*, WU TX, Liu L, Miao JX, Wong HF, Song L, Sung JJY. Effectiveness of the Chinese herbal formula TongXieYaoFang for irritable bowel syndrome: a systematic review. J Altern Complement Med., 2006, 12, 401-407.