Hong Kong Baptist University - School of Chinese Medicine

Dr LI Min

Programme Director of BCM and BScBS and Associate Professor, Teaching Division
Expert in Traditional Chinese Medicine, Pharmacology of Chinese Medicine, Neurodegenerative Diseases and Cardio-cerebrovascular Diseases

Dr. Min Li obtained her Bachelor's degree from the Henan College of Traditional Chinese Medicine (China) in 1985. After being instructed by the renowned Chinese Medicine expert Prof. Tie-tao DENG, Dr. Li finished her Master's study in Internal Chinese Medicine at the Guangzhou University of Traditional Chinese Medicine (China) in 1988 and then obtained the PhD degree in Cardiology at the School of Medicine, Tokai University (Japan) in 2001. Currently, she is an Associate Professor in the School of Chinese Medicine, Hong Kong Baptist University. Dr. Li is also the board member of the Chinese Medicine Council of Hong Kong. She was awarded as the distinguished female Chinese medicine practitioner by the China Association of Chinese medicine in 2007. Dr. Li's clinical specialty is Chinese medicine treatment of neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD) and vascular dementia (VD), as well as on cardio-cerebrovascular diseases. Dr. Li’s clinical research is focus on the study of efficacy and safety of Chinese medicine in treatment of neurodegenerative disease, including PD, AD and VD. Dr. Li’s laboratory research is focus on the investigation of the neuroprotective effects and underlying mechanisms of Chinese medicine on the neurodegenerative diseases including PD and AD, as well as on the inhibition of platelet aggregation, thrombosis formation, and protection of endothelial vascular. Dr. Li has been the Editor-in-Chief and member of the editorial board of over 10 professional books. She has also published over 50 scientific papers and presented over 70 abstracts at international conferences.

Selected Publications

Chua K.K., Chen L.L., Liu L.F., Duriarajan S.S.K., Lu J.H. and Li M.* (2013) “The Efficacy of Classical Chinese Medicine Formula Di-tan Decoction for Alzheimer’s disease” Chin. J. Integra. Med. (Accepted)

Li M.* (2013) “The commonly used ten Chinese medicines on the clinical treatment of dementia” Hong Kong J. Tradi. Chin. Med. (Chin.) 2013, 8(1): 55-58.

Lu JH, Tan JQ, Durairajan SS, Liu LF, Zhang ZH, Ma L, Shen HM, Chan HY and Li M.* (2012) “Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. ” Autophagy. 2012; 8(1):98-108. (Erratum in Autophagy. 2012; 8(5): 864-866.)

Chua K.K., Chau C.S. and Li M.* (2012) “Experimental and clinical research literature review of Tianma Gouteng Yin on the treatment of Parkinson's disease” Hong Kong J. Tradi. Chin. Med. (Chin.) 2012, 7(4): 66-70.

Durairajan S.S.K., Liu L.F., Lu J.H., Chen L.L., Yuan Q.J., Chung S.K., Huang L., Li X.S., Huang J.D.* and Li M.* (2012) “Berberine Ameliorates Beta-amyloid Pathology, Gliosis and Cognitive Impairment in an Alzheimer's Disease Transgenic Mouse Model”. Neurobiol. Aging (DOI:10.1016/j. neurobiolaging. 2012.02.016)

Lu J.H., Song J.X., Durairajan S.S.K., Liu L.F., and Li M.* (2012) “Chinese herbal medicinal compound Cory B promotes the clearance of pathogenic protein aggregations associated with Parkinson’s disease via inducing autophagy”. ACTA Biophysica Sinica. (Suppl.1) 2012, 28(7):21.

Chua K.K., Li M.* (2012) “Literature Review and Data Analysis of Di-tan Decoction on Experimental and Clinical Study of Dementia” Hong Kong J. Tradi. Chin. Med. (Chin.) 2012, 7(2): 72-75.

Man S.C., Chan K.W., Lu J.H., Durairajan S.S.K., Liu L.F. and Li M. * (2012) “Systematic Review on the Safety and Efficacy of Herbal Medicine for the Treatment of Vascular Dementia”. Evid. Based Complement. Alternat. Med. (DOI:10.1155/ecam/2012/426215)

Hui M.L., Chua K.K. and Li M.* (2011) “A literature Review on the Treatment of Chinese Medicine in Neurodegenerative Diseases through Supplying Kidney Qi, Promote Blood Circulation and Dispel Phlegm”. Hong Kong J. Tradi. Chin. Med. (Chin.) 2011, 6(4): 35-40.

Liu L.F., Durairajan S.S.K., Lu J.H., Koo I. and Li M. * (2011) “In Vitro Screening on Amyloid Precursor Protein Modulation of Plants used in Ayurvedic and Traditional Chinese Medicine for Memory Improvement”. J. Ethnopharmacol. (DOI: 10.1016/j.jep.2011.08.065)

Duriarajan S.S.K., Liu L.F., Lu J.H, Koo I., Chung S.K., Maruyama K., Huang J.D. and Li M.* (2011). “Beberine Inhibits Abeta Production, Plaque Formation, Gliosis and Cognitive Deterioration in a Transgenic Mouse Model of Alzheimer’s disease”. Neurodegener. Dis. 2011;8 (Suppl.1):1 (DOI:10. 1159/ 000327701)

l Durairajan S.S.K., Liu L.F., Lu J.H., Koo I., Maruyama K., Chung S. K., Huang J.D.* and Li M.* (2011). “Stimulation of Non-amyloidogenic Processing of Amyloid Precursor Protein by Cryptotanshinone Involves Activation and Translocation of ADAM-10 and PKC-alpha”. J. Alzheimer’s Dis. 2011, 25: 245-262.

Lu J.H., Ardah M.T., Durairajan S.S.K., Liu L.F., Xie L.X., Fong W.F., Hasan M. Y., Huang J.D., El-Agnaf M. A. Omar* and Li M.*(2011). “Baicalein Inhibits Formation of Alpha-synuclein Oligomers within Living Cells and Prevents Abeta Fibrillation and Oligomerization”. ChemBioChem. 2011,12:615-624.

Kum W.F., Durairajan S.S.K., Bian Z.X., Lam Y.C., Man S.C., Xie L.X., Lu J.H., Huang X.Z. and Li M.*(2011). “Treatment of Idiopathic Parkinson’s Disease with Traditional Chinese Herbal Medicine: A Randomized Placebo-Controlled Pilot Clinical Study”. Evid. Based Complement. Alternat. Med. 2011:724353.

Li M. * (2010). “The knowledge of Chinese medicine and its treatment strategies to the dementia”. Hong Kong J. Tradi. Chin. Med. (Chin.) 2010, 5(4): 10-14.

Xie L.X., Durairajan S.S.K., Lu J.H., Liu C.L., Kum W.F., Wu W.K., Han D., Liao F.L., Huang J.D. and Li M.*(2010) “The Effect of Salvianolic acid B Combined with Laminar Shear Stress on TNF-alpha stimulated Adhesion Molecule Expression in Human Aortic Endothelial Cells”. Clin. Hemorhe. Mecro. 2010,44:245-258.

Chan W.H. and Li M.* (2010). “The Study of the Pathogenesis and Applications of Prescriptions of Palpitation from Ancient Literatures”. Hong Kong J. Tradi. Chin. Med. (Chin.) 2010, 5(2): 16-18.

Chan W.S.^†, Durairajan S.S.K.^†, Lu J.H., Xie L.X., Wang Y., Kum W.F., Koo I.,

Yung K.K.L. and Li M.*(2009). “The Neuroprotective Effects of Astragaloside IV (AS-IV) in 6-OHDA-treated Nigral Primary Cell Culture”. Neurochem. Int. 2009, 55: 414-422.

Kum W. F., Gao J., Durairajan S.S.K., Man S.C., Xie L.X., Lu J.H. Fong W.L. and Li M.* (2009). “Risk Factors in Development of Motor Complications in Chinese Patients with Idiopathic Parkinson’s disease”. J. Clin. Neurosci. 2009, 16: 1034-1037.

Lam Y. C., Kum W.F., Lu J.H., Durairajan S.S.K., Man S. C., Xu M., Zhang X. F., Huang X. Z. and Li M.*(2008) “Efficacy and Safety of Acupuncture for Idiopathic Parkinson’s disease: A Systematic Review”. J. Altern. Complem. Med. 2008, 14(6): 663-671.

Xie L.X., Durairajan S.S.K., Liu C.L., Lu J.H., Kum W. F., Huang J. D., Liao F.L., Li M.* (2008). “The Effect of Salvianolic Acid B on TNF-a-stimulated Adhesion Molecule Expression under Flow Condition in Endothelial Cells”. Biorheology. 2008; 45(1, 2): Suppl.42-43.

Wang Z., Li M, Wu W.K., Tan H.M., Geng D.F. (2008). “Ginsenoside Rb1 Preconditioning Protects against Myocardial Infarction after Regional Ischemia and Reperfusion by Activation of Phosphatidylinositol-3-kinase Signal Transduction”. Cardiovasc Drugs Ther. 2008; 22(6):443-452.

Man S.C., Durairajan S.S.K., Kum W. F., Lu J.H., Huang J.D., Cheng C.F., Chung V., Xu M. and Li M.* (2008). “Systematic Review of the Efficacy and Safety of Herbal Medicines for Alzheimer’s Disease”. J. Alzheimer’s Dis. 2008, 14(2): 209-223.

Li M.*, Zhao M.Q., Durairajan S.S.K., Xie L. X., Zhang H.X., Kum W. F., Goto S., Liao F.L. (2008). “Protective Effect of Tetramethylpyrazine and Salvianolic Acid B on Apoptosis of Rat Cerebral Microvascular Endothelial Cell under High Shear Stress”. Clin. Hemorhe. Mecro. 2008, 38:177-187.

Durairajan S.S.K., Yuan Q.J., Xie L.X., Chan W.S., Kum W.F., Koo I., Liu C.L., Song Y.Q., Huang J.D.*, Klein W.L. and Li M.* (2008). “Salvianolic Acid B Inhibits Aβ Fibril Formation, Disaggregates Preformed Fibrils, and Protects Against Aβ-induced Cytotoxicity”. Neurochem.Int. 2008, 52: 741-750.

Zhang H.Q., Yau Y.F., Wong M.S., Man O.Y., He Y.Y., Chan N. and Li M. (2008). “Chinese Medicine Formula DSQRL versus Glucocorticoids for the Treatment of Experimental Pulmonary Fibrosis”. J. Ethnopharmacol. 2008; 116: 318-324.

Liu C.L., Xie L. X., LiM.,* Kumar D.S.S., Goto S., Huang J.D.* (2007). “Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through Regulating PI3K/Akt Signaling”. PLoS ONE 2(12): e1321. DOI: 10.1371/ journal.pone.0001321. 2007.12.19

Zhang H.Q., Yau Y.F., Szeto K.Y., Chan W.T., Wong J., Li M. (2007). “Therapeutic Effect of Chinese Medicine Formula DSQRL on Experimental Pulmonary Fibrosis”. J. Ethnopharmacol. 2007; 109: 543-546.

Chung V., Liu L., Bian Z.X., Zhao ZZ., Fong W.L., Kum W.F., Gao J., Li M.* (2006). “The Efficacy and Safety of Herbal Medicines for Idiopathic Parkinson’s Disease: a Systematic Review”. Movement Disord. 2006; 21: 1709-1715.

Liao F. L., Li M., Han D., Cao J., Chen K.J. (2006) “Biomechanopharmacology – a New Borderline Discipline”. Trends. Pharmacol. Sci. 2006; 27:287-289.

Bian Z.X., Zhang G.S., Wong K.L., Hu X.G., Liu L., Yang Z.J., Li M. (2006). “Inhibitory Effects of Magnolol on Distal Colon of Guinea Pig in Vitro”. Biol. Pharm. Bull. 2006; 29: 790-795.

Zhao C., Li M., Luo Y.F., Wu W.K. (2006). “Isolation and Structural Characterization of an Immunostimulating Polysaccharide from Fuzi, Aconitum carmichaeli”. Carbohydrate Res. 2006; 341: 485-491.

Leung C.Y., Liu L., Wong Ricky N.S., Zeng Y. Y., Li M., Zhou H. (2005). “Saikosaponin-d inhibits T cell activation through the modulation of PKCθ, JNK and NF-κB transcription factor”. J. Biochem. Biophys. Res. Commun. 2005; 338:1920-1927.

Liao F.L., Cao J., Li M., You Y. (2005). “The Methodology in Biomechanopharmacology”. Biorheology. 2005; 42: Suppl. 58-59.

Li M.,* Zhao M.Q., Zhang H.X., Goto S., Wu W.K., and Liao F.L. (2005). “Anti-apoptosis Effects of Tetramethylpyrazine and Salvianolic Acid B on Rat Cerebral Microvascular Endothelial Cells under High Shear Stress”. Biorheology. 2005; 42: Suppl. 57.

Jiang Z.H., Wang J.R., Li M., Liu Z.Q., Chau K.Y., Zhao C., Liu L.(2005). “Two Novel Hemiterpene Glucosides with Potent Anti-Platelet Aggregation Activities from Ilex Pubescens”. J. Nat. Prod. 2005; 68: 397-399.

Bian Z.X., Liu L., Li M. (2004). “The Treatment of TCM on Post-SARS Syndrome”. J. Trad. Chin. Med. (Chin.) 2004; 45(3):236.

Li M.,* Zhao C., Wong Ricky N.S., Goto S., Wang Z.M. and Liao F.L. (2004). “Inhibition of Shear-induced Platelet Aggregation in Rat by Tetramethylpyrazine and Salvianolic acid B”. Clin. Hemorheol. Microcirc.2004; 31:97-103.

Li M.,* Wu W.K., Liu L., Liao F.L., Handa S. and Goto S. (2004). “Specific Inhibiting Effects of Ilexonin A on von Willebrand Factor-dependent Platelet Aggregation Under High Shear Rate”. Chin. Med. J.,(Eng.). 2004; 117: 241-246 .

Goto S., Tamura N., Li M., Handa M., Ikeda Y., Handa S. and Ruggeri Z.M. (2003). “Different Effects of Various Anti-GPIIb-IIIa Agents on Shear-Induced Platelet Activation and Expression of Procoagulant Activity”. J. Thromb. Haemost. 2003; 1: 2022-2030.

Li M.,* Liu L., Zhang X.H., Yeh M.-L., Liao F.L. (2003). “Correlation Between Shear Induced Platelet Aggregation and Viscosity Parameter for Platelet-rich Plasma”. Clin. Hemorheol Microcirc. 2003; 28:259-261.

Li M.,* Liao F.L., Handa S., Goto S. and Liu L. (2002). “Characteristics of the Chinese Herbal Medicines, Ligustrazine Hydrochloride on Platelet Thrombus Formation Occurring Under Flow”. Biorheology. 2002; 39: Suppl.463.

Izumi Y. and Li M. (2001). “The Initial Exploration of Chinese Medical Diagnosis (II)”. East. Med. (Jap.) 2001; 17: 71-76.

Izumi Y. and Li M. (2001). “The Initial Exploration of Chinese Medical Diagnosis (I)”. East. Med. (Jap.) 2001; 16: 73-77.

Izumi Y. and Li M. (2001). “The Entrance of Learning Chinese Medicine”. J. Kanagawa Med. Society. (Jap.) 2001; 27:185-192.

Izumi Y. and Li M. (2001). “The Chinese Medical Treatment on Neurological Disease”. Clin. Neurosci. (Jap.) 2001; 19: 144-145.

Li M., Handa S., Ikeda Y. and Goto S. (2001). “Specific Inhibiting Characteristics of Tetramethylpyrazine, one of the Active Ingredients of the Chinese Herbal Medicine ‘Chuanxiong’, on Platelet Thrombus Formation under High Shear Rates ”. Thromb. Res. 2001; 104: 15-28.

Niu X.L., Ichimori K., Yang X., Hirota Y., Hoshiai K., Li M. and Nakazawa H. (2000). “Tanshinone II-A Inhibits Low Density Lipoprotein Oxidation in Vitro”. Free Radical. Res. 2000; 33:305-312.

Goto S., Ichikawa N., Li M., Goto M., Kim J.Y., Yoshida M., Ikeda Y., Handa S. (2000). “Platelet Surface P-selectin Molecules Increased after Exposing Platelet to a High Shear Flow”. Inter. Angio. 2000; 19:147-151.

Izumi Y. and Li M. (2000). “A Clinical Case Report of Acute Thalamic Dementia Was Treated by Powder of Angelicae Sinensis and Paeoniae”. J. Uni. Guangzhou Trad. Chin. Med. (Chin.) 2000; 17: 358-359.

Li M., Goto S., Sakai H., Kim J.Y., Ichikawa N., Yoshida M., Ikeda Y. and Handa S. (2000). “Enhanced Shear-Induced von Willebrand Factor Binding to Platelets in Acute Myocardial Infarction”. Thromb. Res. 2000; 100:251-261.

Kim J.Y., Goto S., Sakai H., Ichikawa N., Yoshida M., Li M., Miyuki O., Ikeda Y., Handa S. (1999). “The Effect of Plasma Concentration on Shear-induced von Willebrand Factor-mediated Platelet Aggregation”. Jap. J. Thromb. Haemost. 1999; 10:251-259.

[*, corresponding author(s); ^†, contribution equally/sharing first authorship]