Prof LYU Aiping (LU Aiping)

  • Dean of School of Chinese Medicine; Dr. Kennedy Y.H. Wong Endowed Chair of Chinese Medicine; Director, Law Sau Fai Institute for Advancing Translational Medicine in Bone & Joint Diseases; Director, Shum Yiu Foon Shum Bik Chuen Memorial Centre for Cancer & Inflammation Research; Director, Institute of Integrated Bioinformedicine and Translational Science; Director, Institute for Precision Medicine and Innovative Drug; Director, Hong Kong Baptist University Joint Centre for Pain Research
  • Expert in Chinese Medicine, Clinical Pharmacology and Arthritis and related new drug discovery
  • aipinglu@hkbu.edu.hk

Professor Lyu Aiping is Chair Professor & Dean of School of Chinese Medicine, Hong Kong Baptist University, Director of Institute for Advancing Translational Medicine in Bone & Joint Diseases (TMBJ) of HKBU, Director of Institute of Integrated Bioinformedicine & Translational Science (IBTS) of HKBU, Chair Professor in China Academy of Chinese Medical Sciences (CACMS) and Recipient of the Distinguished Young Scholar in National Science Foundation of China (NSFC) in 2007. He is the member of the 11th and 12th the National Committee of the Chinese People's Consultative Conference (CPPCC), and the member of the 11 th Beijing Committee of the Chinese People's Consultative Conference. Prof. Lyu is also the member of Hong Kong Chinese Medicine Development Committee, the member of Hong Kong Chinese Medicine Administration Committee, the member of Biology and Medicine Panel in Hong Kong Research Grant Committee (RGC).

Being a renowned expert and academic in the field, Prof Lyu has been appointed as Head & Spokesperson of the China Delegation, International Organization for Standardization Technical Committee on TCM (ISO/TC249) since 2009.  Besides, he also currently serves as Member of Medical Advisory Committee of National Natural Science Foundation of China (NSFC), Member of Chinese Pharmacopoeia Commission and Vice-Chairman, Terminology of Traditional Chinese Medicine Sub-Committee, China National Committee for Terms in Sciences and Technologies (CNCTST). Also he is the director of Chinese Medicine Standardization Office in State Administration of Traditional Chinese Medicine (SATCM), and the director of Chinese Medicine Standard Research Center in CACMS.

He obtained his bachelor degree from Jiangxi University of Traditional Chinese Medicine in 1983, and further obtained his master's and Ph.D. degrees from China Academy of Traditional Chinese Medicine (now called the China Academy of Chinese Medical Sciences, CACMS).  From 2006 to 2012, he was the Director of Institute of Basic Research in Clinical Medicine, and the Director of Institute of Basic Theory of CACMS from 1999 to 2002.  In 2002-2006, Prof Lyu was appointed as General Director, Jiangxi Herbfine Hi-tech Co. Ltd (National Pharmaceutical Engineering Centre for Solid Preparation), one of four centres in China in the field of Traditional Chinese Medicine industry.

His research interests mainly focus on the translational research in Chinese medicine, including pharmacological and clinical evaluation on rheumatoid arthritis with TCM pattern diagnosis and interventions, and development of new drugs based on Chinese medicines. Also he is actively involving the research on the standardization of Chinese medicine and strategic plan research for Chinese medicine development in China.

Prof Lyu has published more than 30 books and over 500 articles, including 200 articles in SCI journals such as Nature Medicine, Nature Communication, Biomaterials, Briefings in Bioinformatics, Clinical Pharmacology and Therapeutics, Scientific Reports, Journal of Proteomic Research. With his leadership, 3 standards related to Chinese medicine have been issued. One is the General Guidelines for Clinical Practice guideline in Chinese Medicine issued by Chinese Association of Chinese Medical Sciences, and other 2 related to Chinese medicine Coding Systems issued as national standards. As the head or deputy head, he led a team and completed several strategic research reports, including Health China 2020, the 13th Five Year Planning on Chinese Medicine Research in NSFC, strategic planning for Chinese medicine standardization (both domestic and internal). Over the years, he obtained more than 60 patents from his research activities. 

He was invited to serve as Visiting Scholar in a number of institutions including Lund University in Sweden, Ohio State University in the United States, Hong Kong Polytechnic University and Hong Kong University of Science and Technology. Based on his outstanding research achievement, Prof Lyu was invited as guest speakers in various international academic conferences.

Selected Publications

  • Li D, Liu J, Guo B, Liang C, Dang L, Lu C, He X, Cheung HY, Xu L, Lu C, He B, Liu B, Shaikh AB, Li F, Wang L, Yang Z, Au DW, Peng S, Zhang Z, Zhang BT, Pan X, Qian A, Shang P, Xiao L, Jiang B, Wong CK, Xu J, Bian Z, Liang Z, Guo DA, Zhu H, Tan W, Lu A, Zhang G. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun. 2016:7:10872.
  • Yao H, Jiang F, Lu A, Zhang G. Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs). Int J Mol Sci. 2016: 17(2). pii: E194.
  • Zhou W, Wang Y, Lu A, Zhang G. Systems Pharmacology in Small Molecular Drug Discovery. Int J Mol Sci. 2016:17(2). pii: E246.
  • Yu Y, Liang C, Lv Q, Li D, Xu X, Liu B, Lu A, Zhang G. Molecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers. Int J Mol Sci. 2016:11;17(3). pii: E358.
  • Wang C, Liu B, Xu X, Zhuang B, Li H, Yin J, Cong M, Xu W,, Lu A. (2016) Toward targeted therapy in chemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine. Oncotarget. [Epub ahead of print]
  • Tan Y, Liu X, Zhou K, He X, Lu C, He B, Niu X, Xiao C, Xu G, Bian Z, Zu X, Zhang G, Zhang W, Lu A. The Potential Biomarkers to Identify the Development of Steatosis in Hyperuricemia. PLoS One 2016:11(2):e0149043.
  • Yu Y, Liang C, Lv Q, Li D, Xu X, Liu B, Lu A, Zhang G. Molecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers. Int J Mol Sci. 2016 Mar 11;17(3).
  • Gong Y, Lin Y, Zhao N, He X, Lu A, Wei W, Jiang M. The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population. Mediators Inflamm. 2016;2016:7089137.
  • Ning Z, Liu Z, Song Z, Zhao S, Dong Y, Zeng H, Shu Y, Lu C, Liu Y, Lu A. A single marker choice strategy in simultaneous characterization and quantification of multiple components by rapid resolution liquid chromatography coupled with triple quadrupole tandem mass spectrometry (RRLC-QqQ-MS). J Pharm Biomed Anal. 2016 Mar 3;124:174-188.
  • Zhang B, Fu Y, Huang C, Zheng C, Wu Z, Zhang W, Yang X, Gong F, Li Y, Chen X, Gao S, Chen X, Li Y, Lu A, Wang Y. New strategy for drug discovery by large-scale association analysis of molecular networks of different species. Sci Rep. 2016 Feb 25;6:21872.
  • Zhou W, Wang Y, Lu A, Zhang G. Systems Pharmacology in Small Molecular Drug Discovery. Int J Mol Sci. 2016 Feb 18;17(2).
  • Tan Y, Liu X, Zhou K, He X, Lu C, He B, Niu X, Xiao C, Xu G, Bian Z, Zu X, Zhang G, Zhang W, Lu A. The Potential Biomarkers to Identify the Development of Steatosis in Hyperuricemia. PLoS One. 2016 Feb 18;11(2):e0149043.  
  • Wang C, Liu B, Xu X, Zhuang B, Li H, Yin J, Cong M, Xu W, Lu A. Toward targeted therapy in hemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine. Oncotarget. 2016 Jan 29. doi: 10.18632/oncotarget.7073. [Epub ahead of print]
  • Jiang M, Zha Q, Zhang C, Lu C, Yan X, Zhu W, Liu W, Tu S, Hou L, Wang C, Zhang W, Liang Q, Fan B, Yu J, Zhang W, Liu X, Yang J, He X, Li L, Niu X, Liu Y, Guo H, He B, Zhang G, Bian Z, Lu A. Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial. Sci Rep. 2015 Apr 15;5:9700.
  • Zhang X, Ng HL, Lu A, Lin C, Zhou L, Lin G, Zhang Y, Yang Z, Zhang H. Drug delivery system targeting advanced hepatocellular carcinoma: Current and future. Nanomedicine. 2016 Jan 7. pii: S1549-9634(16)00005-8. doi: 10.1016/j.nano.2015.12.381. [Epub ahead of print]
  • Li Y, Wang J, Xiao Y, Wang Y, Chen S, Yang Y, Lu A, Zhang S. A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis. J Ethnopharmacol. 2015:175:301-314.
  • Guo J, Qin S, Liang J, Lin T, Si L, Chen X, Chi Z, Cui C, Du N, Fan Y, Gu K, Li F, Li J, Li Y, Liang H, Liu J, Lu M, Lu A, Nan K, Niu X, Pan H, Ren G, Ren X, Shu Y, Song X, Tao M, Wang B, Wei W, Wu D, Wu L, Wu A, Xu X, Zhang J, Zhang X, Zhang Y, Zhu H; written; Chinese Society of Clinical Oncology (CSCO) Melanoma Panel. Chinese Guidelines on the Diagnosis and Treatment of Melanoma (2015 Edition). Ann Transl Med. 2015 Dec;3(21):322.
  • Zhao N, Li J, Li L, Niu XY, Jiang M, He XJ, Bian ZX, Zhang G, Lu A. Molecular network-based analysis of guizhi-shaoyao-zhimu decoction, a TCM herbal formula, for treatment of diabetic peripheral neuropathy. Acta Pharmacol Sin. 2015 Jun;36(6):716-723.
  • Zhang B, Lu C, Bai M, He X, Tan Y, Bian Y, Xiao C, Zhang G, Lu A, Li S. (2015) Tetramethylpyrazine identified by a network pharmacology approach amel iorates methotrexate-induced oxidative organ injury. J Ethnopharmacol.175:638-647.
  • Lin C, Ng HL, Pan W, Chen H, Zhang G, Bian Z, Lu A, Yang Z. Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy. Int J Mol Sci. 2015 Nov 11;16(11):26936-52.
  • Fatima S, Shi X, Lin Z, Chen GQ, Pan XH, Wu JC, Ho JW, Lee NP, Gao H, Zhang G, Lu A, Bian ZX. 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. Mol Oncol. 2016 Feb;10(2):195-212.
  • Jiang F, Liu B, Lu J, Li F, Li D, Liang C, Dang L, Liu J, He B, Badshah SA, Lu C, He X, Guo B, Zhang XB, Tan W, Lu A, Zhang G. Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems. Int J Mol Sci. 2015 Oct 9;16(10):23784-822.
  • Zhang B, Lu C, Bai M, He X, Tan Y, Bian Y, Xiao C, Zhang G, Lu A, Li S. Tetramethylpyrazine identified by a network pharmacology approach ameliorates methotrexate-induced oxidative organ injury. J Ethnopharmacol. 2015 Dec 4;175:638-47.
  • Xu S, Zhang T, Kompella SN, Yan M, Lu A, Wang Y, Shao X, Chi C, Adams DJ, Ding J, Wang C. Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci Rep. 2015 Sep 23;5:14261.
  • Niu X, Lu C, Xiao C, Ge N, Jiang M, Li L, Bian Y, Xu G, Bian Z, Zhang G, Lu A. The Crosstalk of Pathways Involved in Immune Response Maybe the Shared Molecular Basis of Rheumatoid Arthritis and Type 2 Diabetes. PLoS One. 2015:10(8):e0134990.
  • Li Y, Wang J, Xiao Y, Wang Y, Chen S, Yang Y, Lu A, Zhang S. A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis. J Ethnopharmacol. 2015 Dec 4;175:301-14.
  • Li P, Huang C, Fu Y, Wang J, Wu Z, Ru J, Zheng C, Guo Z, Chen X, Zhou W, Zhang W, Li Y, Chen J, Lu A, Wang Y. Large-scale exploration and analysis of drug combinations. Bioinformatics. 2015:31(12):2007-2016.
  • Shi N, Zhong LL, Han X, Ziea TC, Ng B, Bian Z, Lu A. Enhanced evidence-based chinese medicine clinical practice guidelines in Hong Kong: a study protocol for three common diseases. Evid Based Complement Alternat Med. 2015:2015:482706.
  • Chen GQ, Tang CF, Shi XK, Lin CY, Fatima S, Pan XH, Yang DJ, Zhang G, Lu AP, Lin SH, Bian ZX. Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism. Oncotarget. 2015:6(27):24148-24162.
  • Liu J, Dang L, Li D, Liang C, He X, Wu H, Qian A, Yang Z, Au DW, Chiang MW, Zhang BT, Han Q, Yue KK, Zhang H, Lv C, Pan X, Xu J, Bian Z, Shang P, Tan W, Liang Z, Guo B, Lu A, Zhang G. A delivery system specifically 2015: 52:148-160.
  • Liang C, Guo B, Wu H, Shao N, Li D, Liu J, Dang L, Wang C, Li H, Li S, Lau WK, Cao Y, Yang Z, Lu C, He X, Au DW, Pan X, Zhang BT, Lu C, Zhang H, Yue K, Qian A, Shang P, Xu J, Xiao L, Bian Z, Tan W, Liang Z, He F, Zhang L, Lu A, Zhang G. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat Med 2015: 21(3):288-294.
  • Li J, Liu Z, Guo M, Xu K, Jiang M, Lu A, Gao X. Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis. Evid Based Complement Alternat Med. 2015:2015:897914.
  • Wang Y, Guo Z, Chen X, Zhang W, Lu A, Wang Y. Multi-scale modeling of cell survival and death mediated by the p53 network: a systems pharmacology framework. Mol Biosyst. 2015 Nov;11(11):3011-21.
  • Fan L, Gong J, Fu W, Chen Z, Xu N, Liu J, Lu A, Li Z, Wu T, Ou A, Xie H. Gender-Related Differences in Outcomes on Acupuncture and Moxibustion Treatment Among Depression Patients. J Altern Complement Med. 2015 Nov;21(11):673-80.
  • Deng Y, Yang M, Xu F, Zhang Q, Zhao Q, Yu H, Li D, Zhang G, Lu A, Cho K, Teng F, Wu P, Wang L, Wu W, Liu X, Guo DA, Jiang B. Combined Salvianolic Acid B and Ginsenoside Rg1 Exerts Cardioprotection against Ischemia/Reperfusion Injury in Rats. PLoS One. 2015 Aug 17;10(8):e0135435.
  • Niu X, Lu C, Xiao C, Ge N, Jiang M, Li L, Bian Y, Xu G, Bian Z, Zhang G, Lu A. The Crosstalk of Pathways Involved in Immune Response Maybe the Shared Molecular Basis of Rheumatoid Arthritis and Type 2 Diabetes. PLoS One. 2015 Aug 7;10(8):e0134990.
  • Jiang F, Liu B, Lu J, Li F, Li D, Liang C, Dang L, Liu J, He B, Badshah SA, Lu C, He X, Guo B, Zhang XB, Tan W, Lu A, Zhang G. ) Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems. Int J Mol Sci. 2015:16(10):23784-23822.
  • Li J, Liu Z, Guo M, Xu K, Jiang M, Lu A, Gao X. Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis. Evid Based Complement Alternat Med. 2015;2015:897914.
  • Lu A, Xue C, Bian Z, Cho WC. TCM Zheng Classification and Clinical Trials 2014. Evid Based Complement Alternat Med. 2015;2015:538989.
  • Liu J, Dang L, Li D, Liang C, He X, Wu H, Qian A, Yang Z, Au DW, Chiang MW, Zhang BT, Han Q, Yue KK, Zhang H, Lv C, Pan X, Xu J, Bian Z, Shang P, Tan W, Liang Z, Guo B, Lu A, Zhang G. A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts. Biomaterials. 2015 Jun;52:148-60.
  • Shi N, Zhong LL, Han X, Ziea TC, Ng B, Bian Z, Lu A. Enhanced evidence-based Chinese medicine clinical practice guidelines in Hong Kong: a study protocol for three common diseases. Evid Based Complement Alternat Med. 2015;2015:482706.
  • Gong Y, Liu L, He X, Zhao H, Yang J, Li L, Lu A, Lin Y, Jiang M. The th17/treg immune balance in ulcerative colitis patients with two different chinese syndromes: dampness-heat in large intestine and spleen and kidney yang deficiency syndrome. Evid Based Complement Alternat Med. 2015;2015:264317.
  • Liang C, Li D, Zhang G, Li H, Shao N, Liang Z, Zhang L, Lu A, Zhang G. Comparison of the methods for generating single-stranded DNA in SELEX. Analyst. 2015 May 21;140(10):3439-44.
  • Kwan HY, Niu X, Dai W, Tong T, Chao X, Su T, Chan CL, Lee KC, Fu X, Yi H, Yu H, Li T, Tse AK, Fong WF, Pan SY, Lu A, Yu ZL. Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers. Sci Rep. 2015 Mar 13;5:9114
  • He YX, Liu J, Guo B, Wang YX, Pan X, Li D, Tang T, Chen Y, Peng S, Bian Z, Liang Z, Zhang BT, Lu A, Zhang G. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. Sci Rep. 2015 Mar 9;5:8856.
  • Du Z, Liu Z, Ning Z, Liu Y, Song Z, Wang C, Lu A. Prospects of boswellic acids as potential pharmaceutics. Planta Med. 2015 Mar;81(4):259-71.
  • Jia W, Lu A, Chan K, Gustafsson MG, Liu P. Translational research in complementary and alternative medicine 2014. Evid Based Complement Alternat Med. 2015;2015:427508.
  • Li P, Huang C, Fu Y, Wang J, Wu Z, Ru J, Zheng C, Guo Z, Chen X, Zhou W, Zhang W, Li Y, Chen J, Lu A, Wang Y. Large-scale exploration and analysis of drug combinations. Bioinformatics. 2015 Jun 15;31(12):2007-16.

*corresponding author

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