Dr CHEUNG King-Ho
- Associate Professor, Teaching and Research Division
- Expert in ion channel, electrophysiology, epithelial transport and Alzheimer's disease.
Dr. Cheung is a local trained scientist. He obtained his Bachelor Degree from The Hong Kong Polytechnic University in 1999 and PhD in Physiology from The Chinese University of Hong Kong in 2004. After that, he pursued his postdoctoral training in electrophysiology and calcium signaling at The University of Pennsylvania (Philadelphia, PA, USA) under the supervision of Prof. Kevin Foskett (2004-2010).
In 2010, He took up the Assistant Professor position at the Department of Physiology, University of Hong Kong and joined the School of Chinese Medicine, Hong Kong Baptist University in 2017 as the Associate Professor. Dr.Cheung's research focuses on the structure/function of ion channels and their roles in disease pathogenesis, particularly in the Alzheimer's disease. His work has been published in several top-ranked journals including Neuron, Cell, PNAS and Science Signaling.
Dr. Cheung's research interests are:
- Structure function of intracellular calcium release channels (inositol trisphosphate receptors, ryanodine receptors and two-pore channel) and their roles in health and disease.
- Molecular mechanisms for Alzheimer's disease pathogenesis (calcium disruption and neuronal autophagy)
- Development of pharmacological compounds from Chinese medicine for Alzheimer's disease therapy.
Dr. Cheung's group is looking for self-motivated graduate students and research assistants who are interested in the area of neurodegeneration or molecular physiology to join the group. Candidates with background in molecular biology, cell biology, calcium imaging or electrophysiology may have an advantage. Individual who is interested in the post can email Dr. Cheung for more information.
- Tong CK, Lee SK, Cheng WH, Lai KO, Foskett JK and Cheung KH. (2016) Familial Alzheimer's disease-associated presenilin 1 mutants promote g-secretase cleavage of STIM1 to impair store-operated Ca2+ entry. Sci. Signal. 9:ra89. Corresponding author. News in Alzforum.org.
- Lee SK, Tong CK,Cheng WH, Hung CH and Cheung KH. (2016) Characterization of two-pore channel 2 by nuclear membrane electrophysiology. Sci Rep 6: 2028 Corresponding author.
- Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong CWM, Ma V WS, Yip TTC, Au JSK, Cheung KH, Wu W, Li GR and Yue J (2016). Mechanistic study of TRPM2-Ca2+-CAMK2-BECN1 signaling in oxidative stress induced autophagy inhibition. Autophagy 12: 1340-1354.
- Ullah G, Cheung KH, Toglia P, and Mak D-OD (2015). Analysing and quantifying the gain-of-function enhancement of IP3 receptor gating by familial Alzherimer's disease-causing mutations in presenilins. PLoS Comput. Biol. 11:e1004529.
- Mak DO, Vais H, Cheung KH, and Foskett JK. (2013) Patch-clamp electrophysiology of intracellular Ca2+ channels. Cold Spring Harb Protoc 2013(9):787-797.
- Muller M, *Cheung KH, and Foskett JK (2011) Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling. Antioxid Redox Signal 14: 1225-1235.*Co-first authors.
- Muller M, Cardenas C, Mei L, Cheung KH and Foskett JK (2011) Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling. Proceeding in National Academy of Sciences of the United States of American 108: 13293-13298.
- Cheung KH, Mei L, Mak DO, Hayashi I, Iwatsubo T, Kang DE and Foskett JK (2010) Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. Sci. Signal. 3:ra22. Journal Cover.
- Cardenas C, Miller RA, Smith I, Bui T, Molgo J, Muller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR and Foskett JK (2010) Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell 142: 270-283. (Impact factor: 32.242; number of citations: 225). Recommended in F1000 Prime.
- Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, and Foskett JK. (2008) Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron 58: 871-883. Recommended in F1000 Prime.
- Foskett JK, White C, Cheung KH and Mak DO (2007) Inositol trisphosphate receptor Ca2+ release channels. Physiological Reviews 87: 593-658.
- Cheung KH, Leung GP, Leung MC, Shum WW, Zhou WL and Wong PY (2005) Cell-cell interaction underlies formation of fluid in the male reproductive tract of the rat. Journal of General Physiology 125: 443-454. (Impact factor: 4.788; number of citations: 28). Journal Cover.
- Cheung KH, Leung CT, Leung GP and Wong PY (2003) Synergistic effects of cystic fibrosis transmembrane conductance regulator and aquaporin-9 in the rat epididymis. Biology of Reproduction 68: 1505-1510.