Patents

Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2020
A mTOR-independent Activator of TFEB for Autophagy Enhancement and Uses thereof Min LI, Yu ZENG, Liangfeng LIU, Juxian SONG European Procedure (Patents) 2020-12-09 EP3113767B1
Method of Using Dihydro-resveratrol for Treating Acute Pancreatitis and Associated Pulmonary Injury Zhaoxiang BIAN, Sun Chi Albert CHAN, Siu Wai TSANG, Aiping LU, Hongjie ZHANG Hong Kong 2020-08-07 HK 1230076 B
Anti-Esophageal Cancer Compound and Method of Use thereof Chengyuan LIN, Zhijun YANG, Zhaoxiang BIAN, Sun Chi Albert CHAN, Huaixue MU, Aiping LU, Jinjin WANG China 2020-04-24 ZL 201610466298.4
Composition of Halofuginone and Artemisia Apiacea and Sesquiterpene Lactone Compounds for Resisting Cancer and Application of Composition Zhaoxiang BIAN, Dajian YANG, Aiping LU, Guoqing CHEN, Ruihong Gong China 2020-01-24 ZL 201610006000.1
Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2019
Method of Use of Diterpenoid Derivatives as Anticancer Agents Siu Wai TSANG, Lei GUO, Tongxin Zhang, Man Shing Ricky WONG, Kanglun LIU, Hongjie ZHANG United States 2019-12-03 US 10493056
Method and the Lignan Compound of Suppression Esophageal Carcinoma Growth in Main Body in Need Treat the Application of Esophageal Cancer Medicine as Preparation Chengyuan LIN, Zhaoxiang BIAN, Sun Chi Albert CHAN, Huaixue MU, Hongxi XU, Shilin CHEN, Dajian YANG, Aiping LU Hong Kong 2019-11-22 HK1229716
Anticancer Maytansinoids with Two Fused Macrocyclic Rings Djaja D. SOEJARTO, H.S. Harry FONG, Hongjie ZHANG Hong Kong 2019-11-08 HK 1221722B
Long-Acting Controlled-Release Liposome Gel Composition Comprising Hypoglycemic Active Ingredient and Preparation Method Thereof Zhijun YANG, Zhaoxiang BIAN, Aiping LU, Blenda Chi Kwan WONG, Xiaoyu CHEN Hong Kong 2019-11-08 HK 1208626
Method of Using Dihydro-resveratrol for Treating Acute Pancreatitis and Associated Pulmonary Injury Zhaoxiang BIAN, Sun Chi Albert CHAN, Siu Wai TSANG, Aiping LU, Hongjie ZHANG China 2019-10-18 ZL201610409287.2
Identification of Cyclic Peptide Agonists of Galanin Receptor 2 and 3 Guided By Spexin Solution Structure Chengyuan LIN, Tao HUANG, Zhaoxiang BIAN United States 2019-08-13 US 10376555
Quality Control Marker and its Use in Cordyceps Species Authentication Quanbin HAN United States 2019-07-23 US 10359407
Method of Using of Dihydro-Resveratrol or its Stilbenoid Derivatives and/or Chemical Variants as Antimicrobial Agents Siu Wai TSANG, Hongjie ZHANG United States 2019-07-16 US 10351500
Miliusanes as Antiviral Agents Hongjie ZHANG United States 2019-06-18 US 10323012
Method and Compounds for Inhibiting the MCM Complex and their Application in Cancer Treatment Liping BAI, Jingrong WANG, Zhihong JIANG, Chun LIANG, Ziyi WANG, Zhiling YU China 2019-06-11 ZL 201380024370.2
Method and the Lignan Compound of Suppression Esophageal Carcinoma Growth in Main Body in Need Treat the Application of Esophageal Cancer Medicine as Preparation Chengyuan LIN, Zhaoxiang BIAN, Sun Chi Albert CHAN, Huaixue MU, Hongxi XU, Shilin CHEN, Dajian YANG, Aiping LU China 2019-04-02 ZL 201610462255.9
Long-Acting Controlled-Release Liposome Gel Composition Comprising Hypoglycemic Active Ingredient and Preparation Method Thereof Zhijun YANG, Zhaoxiang BIAN, Aiping LU, Blenda Chi Kwan WONG, Xiaoyu CHEN China 2019-03-15 ZL 2014 1 0055853.5
Skin-protection Composition Containing Dendrobium-based Ingredients Siu Wai TSANG, Yu ZHU, Hongjie ZHANG United States 2019-01-29 US 10188590
Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2018
Anti-cancer and Anti-obesity Cyclic Peptide Agents Hongjie ZHANG United Kingdom 2018-12-12 EP 2909227
Anti-cancer and Anti-obesity Cyclic Peptide Agents Hongjie ZHANG European Procedure (Patents) 2018-12-12 EP 2909227
Anti-cancer and Anti-obesity Cyclic Peptide Agents Hongjie ZHANG Germany 2018-12-12 60 2013 048 235.7
Use of a Flavanol Glycoside for Suppressing Activation of Stellate Cells Zhaoxiang BIAN, Siu Wai TSANG, Hongjie ZHANG, Yegao CHEN, Sun Chi Albert CHAN, Aiping LU, Hongxi XU, Shilin CHEN, Dajian YANG Hong Kong 2018-10-05 HK 1202058B
Anticancer Maytansinoids with Two Fused Macrocyclic Rings Hongjie ZHANG, Djaja D. SOEJARTO, H.S. Harry FONG United Kingdom 2018-09-19 3077402
Anticancer Maytansinoids with Two Fused Macrocyclic Rings Hongjie ZHANG, Djaja D. SOEJARTO, H.S. Harry FONG European Procedure (Patents) 2018-09-19 3077402
Anticancer Maytansinoids with Two Fused Macrocyclic Rings Hongjie ZHANG, Djaja D. SOEJARTO, H.S. Harry FONG Germany 2018-09-19 60 2014 032 788.5
Quality Control Marker and Its Use in Herbs Authentication Quanbin HAN, Hubiao CHEN, Jun XU Hong Kong 2018-08-31 HK 1204362
Quality Control Marker and Its Use in Herbs Authentication Quanbin HAN, Hubiao CHEN, Jun XU Macao 2018-08-07 J/003077
Method for the Preparation of Iodoalkanes Zhaoxiang BIAN, Baomin FAN, Chengyuan LIN, Yongyun ZHOU, Jingchao CHEN United States 2018-08-07 US 10040740
Method of Using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatment of tumorous pathologies Siu Wai TSANG, Hongjie ZHANG United States 2018-07-10 US 10017442
Slow and controlled released liposomal gel composition comprising hypoglycemic active ingredient and method of preparing thereof Zhijun YANG, Aiping LU, Zhaoxiang BIAN, Xiaoyu CHEN, Blenda Chi Kwan WONG United States 2018-05-29 US 9980906
Cycloheptapeptide Agents for Treatment of Cancer and Obesity Diseases Hongjie ZHANG United States 2018-05-08 US 9963485
A Chinese Medicinal Formulation for Treating Inflammatory Bowel Disease and the Preparation Thereof Zhaoxiang BIAN, Siu Wai TSANG, Siu Po IP, Che Yuen Justin WU, Aiping LU, Sun Chi Albert CHAN Hong Kong 2018-05-04 HK 1206618
Skin-protection composition containing Dendrobium-based ingredients Hongjie ZHANG, Siu Wai TSANG, Yu ZHU United States 2018-05-01 US 9956152
Anti-cancer and Anti-obesity Cyclic Peptide Agents Hongjie ZHANG China 2018-04-27 ZL 201380048848.5
Use of a Flavanol Glycoside for Suppressing Activation of Stellate Cells Zhaoxiang BIAN, Siu Wai TSANG, Hongjie ZHANG, Yegao CHEN, Sun Chi Albert CHAN, Aiping LU, Hongxi XU, Shilin CHEN, Dajian YANG China 2018-04-06 ZL 201410210304.0
Composition Comprising Rhizoma Coptidis, Cortex Pellodendri and Fructus Gardeniae and For Treating Neurodegenerative Diseases Min LI, Siva Sundara Kumar DURAIRAJAN, Leilei CHEN, Liangfeng LIU, Juxian SONG Hong Kong 2018-03-29 HK 1200119B
Quality Control Marker and Its Use in Herbs Authentication Quanbin HAN, Hubiao CHEN, Jun XU China 2018-03-23 ZL 201410330544.4
Long-Acting Gel Composition Comprising Blood Sugar Reducing Active Component and Capable of Controlling and Releasing Liposome, and preparation Method Thereof Zhijun YANG, Aiping LU, Zhaoxiang BIAN, Xiaoyu CHEN, Blenda Chi Kwan WONG Japan 2018-03-16 JP 6305555
New Triptolide Derivatives, Their Preparation Method and Uses Ge ZHANG, Aiping LU, Cheng WANG, Cheng LU, Jun LU, Biao LIU Hong Kong 2018-03-16 HK 1217708
Herbal Composition for Skin-Whitening and Anti-Skin-Aging, Method of Preparation and the Use thereof Zhiling YU, Hua YU China 2018-03-06 ZL201310063194.5
Method of Using Dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatments of fibrotic and diabetic conditions Siu Wai TSANG, Hongjie ZHANG, Yegao CHEN United States 2018-01-30 US 9877931
Compound for Inhibiting Syk Activity Hongxi XU, Yue LV, Wenwei FU, Kaixian CHEN, Zhaoxiang BIAN, Shilin CHEN, Dajian YANG, Aiping LU, Sun Chi Albert CHAN United States 2018-01-16 US 9868716
Aryl Naphthalide Lignans As anti-HIV Agents Hongjie ZHANG, Djaja D. SOEJARTO, Lijun RONG, H.S. Harry FONG, Emily RUMSCHLAG-BOOMS Hong Kong 2018-01-05 HK 1196608B
Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2017
Anticancer Miliusane Lactams Hongjie ZHANG United States 2017-11-21 US 9822071
Composition Comprising Rhizoma Coptidis, Cortex Pellodendri and Fructus Gardeniae and for Treating Neurodegenerative Diseases Min LI, Leilei CHEN, Siva Sundara Kumar DURAIRAJAN, Liangfeng LIU, Juxian SONG Macao 2017-11-14 J/002740
Triptolide Derivatives and Preparation Method and Use Thereof Jun LU, Cheng LU, Aiping LU, Biao LIU, Cheng WANG, Ge ZHANG United States 2017-11-07 US 9809822
Method of Use of Diterpenoid Derivatives as Anticancer Agents Siu Wai TSANG, Lei GUO, Tongxin ZHANG, Man Shing Ricky WONG, Kanglun LIU, Hongjie ZHANG United States 2017-10-24 US 9795589
A Chinese Medicinal Formulation for Treating Inflammatory Bowel Disease and the Preparation Thereof Zhaoxiang BIAN, Sun Chi Albert CHAN, Siu Wai TSANG, Aiping LU, Che Yuen Justin WU, Siu Po IP China 2017-10-13 CN 104436088B
Palladium/Silver Co-Catalyzed Tandem Reactions Synthesis of Phenylacetophenone Derivatives by Oxabenzonorbornadienes with Terminal Alkynes and Their Anti-Tumor or Anti-Cancer Activities Baomin FAN, Chengyuan LIN, Zhaoxiang BIAN, Sun Chi Albert CHAN, Huaixue MU, Yongyun ZHOU, Jingchao CHEN, Aiping LU United States 2017-10-10 US 9783519
Lignans Isolated from Lasia spinosa (L.) Thwait Chengyuan LIN, Zhaoxiang BIAN, Sun Chi Albert CHAN, Huaixue MU, Hongxi XU, Shilin CHEN, Dajian YANG, Aiping LU United States 2017-10-03 US 9775857
Method of Using Dihydro-Resveratrol or its Stilbenoid Derivatives and/or Chemical Variants in Treatments of Fibrotic and Diabetic Conditions Siu Wai TSANG, Yegao CHEN, Hongjie ZHANG United States 2017-08-22 US 9738581
Composition Comprising Rhizoma Coptidis, Cortex Pellodendri and Fructus Gardeniae and for Treating Neurodegenerative Diseases Min LI, Leilei CHEN, Siva Sundara Kumar DURAIRAJAN, Liangfeng LIU, Juxian SONG China 2017-07-25 CN 104225023B
Anticancer Miliusane Derivatives Hongjie ZHANG, Yifu GUAN United States 2017-07-04 US 9695141 B2
New Triptolide Derivatives, Their Preparation Method and Uses Jun LU, Cheng LU, Aiping LU, Biao LIU, Cheng WANG, Ge ZHANG China 2017-06-16 CN 105121455B
Anti-esophageal Cancer Compound and Method of Use thereof Chengyuan LIN, Zhijun YANG, Zhaoxiang BIAN, Sun Chi Albert CHAN, Huaixue MU, Aiping LU, Jinjin WANG United States 2017-05-23 US 9655913 B2
Synthesis of Autophagy Inducing Compound and the Uses thereof Min LI, Hongjie ZHANG, Liangfeng LIU, Juxian SONG United States 2017-03-28 US 9604987
Aryl Naphthalide Lignans As anti-HIV Agents Lijun RONG, H.S. Harry FONG, Hongjie ZHANG, Djaja D. SOEJARTO, Emily RUMSCHLAG-BOOMS China 2017-02-15 CN 103857674B
Anticancer Maytansinoids with Two Fused Macrocyclic Rings Djaja D. SOEJARTO, H.S. Harry FONG, Hongjie ZHANG United States 2017-02-07 US 9562059
A mTOR-independent Activator of TFEB for Autophagy Enhancement and Uses thereof Min LI, Hongjie ZHANG, Chuanbin YANG, Juxian SONG United States 2017-01-10 US 9540299
Melanogenesis Effect of Saponins of Gynostemma Pentaphyllum Wen Luan Wendy HSIAO, Ting Fung TSANG United States 2017-01-10 US 9539275
Folium Isatidis and Sophora Flavescens External Medicament, Preparation and Application thereof Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Shilin CHEN, Yi ZHANG, Dajian YANG, Aiping LU, Guoqing CHEN China 2017-01-04 CN 103565915B
Abrotani Herba and Folium Isatidis Combined Medicament, Preparation Method and Application thereof Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Shilin CHEN, Yi ZHANG, Dajian YANG, Aiping LU, Guoqing CHEN China 2017-01-04 CN 103566058B
Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2016
Method of Using Dihydro-resveratrol for Treating Acute Pancreatitis and Associated Pulmonary Injury Zhaoxiang BIAN, Sun Chi Albert CHAN, Siu Wai TSANG, Aiping LU, Hongjie ZHANG United States 2016-12-27 US 9526706
Herbal Composition for Skin-Whitening and Anti-Skin-Aging, Method of Preparation and the Use thereof Hua YU, Zhiling YU United States 2016-12-06 US 9511013
One Kind of Honey-Roasted Coltsfoot Processing Methods Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Shilin CHEN, Dajian YANG, Linfang HUANG, Wentao LI China 2016-11-23 CN 103877137B
Medical Use of Compound from Garcinia Esculenta Chengyuan LIN, Hongsheng TAN, Zhi-jie DING, Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Kaixian CHEN, Shilin CHEN, Dajian YANG, Yuanzhi LAO, Aiping LU, Hong ZHANG United States 2016-10-18 US 9468623
Kind of Fresh Folium is a Method for Preparing Raw Material Indirubin Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Shilin CHEN, Yi ZHANG, Dajian YANG, Aiping LU, Guoqing CHEN China 2016-08-31 CN 103509835B
Method of Using Rhein for Treating Fibrotic Conditions and Tumors Hongyan QIN, Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Shilin CHEN, Siu Wai TSANG, Dajian YANG, Aiping LU, Haitao XIAO Hong Kong 2016-08-26 HK 14102293.4
Liver-Protecting Eyesight-Improving Folium Isatidis and Semen Cassiae Drug Pair Combined Medicament, Preparation Method and Application thereof Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Shilin CHEN, Yi ZHANG, Dajian YANG, Aiping LU, Guoqing CHEN China 2016-08-17 CN 103566059B
Turmeric Ethyl Acetate Extract as well as Preparation and Detection Methods and Application thereof Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Shilin CHEN, Dongmei WANG, Dajian YANG, Linfang HUANG, Sensen LIN China 2016-08-17 CN 103690883B
Rhizoma Dryopteris Crassirhizomae Aqueous Extract and Preparation Method and Application thereof Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Shilin CHEN, Dongmei WANG, Dajian YANG, Linfang HUANG, Ailin LIU China 2016-08-10 CN 103720723B
Pharmaceutical Composition Comprising Guttiferone F for the Treatment of Prostate Cancer Xin LI, Hongsheng TAN, Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Kaixian CHEN, Shilin CHEN, Dajian YANG, Yuanzhi LAO, Aiping LU, Hong ZHANG, Xiaoyu WANG United States 2016-08-09 US 9408811
(+)-3’-Angeloyloxy-4’-keto-3’,4’-dihydroseselin for Treating Inflammation Chengyuan LIN, Zhaoxiang BIAN, Sun Chi Albert CHAN, Huaixue MU, Hongxi XU, Shilin CHEN, Dajian YANG, Linfang HUANG, Aiping LU, Quanbin HAN United States 2016-08-09 US 9408828
Composition Comprising Rhizoma Coptidis, Cortex Pellodendri and Fructus Gardeniae and For Treating Neurodegenerative Diseases Min LI, Leilei CHEN, Siva Sundara Kumar DURAIRAJAN, Liangfeng LIU, Juxian SONG United States 2016-06-28 US 9374457
mTOR-independent Activator of TFEB for Autophagy Enhancement and Uses thereof Min LI, Yu ZEND, Liangfeng LIU, Juxian SONG United States 2016-05-31 US 9351946
Anti-cervical cancer compound and method of use thereof Chengyuan LIN, Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Kaixian CHEN, Shilin CHEN, Dajian YANG, Yuanzhi LAO, Aiping LU, Hong ZHANG, Xiaoyu WANG United States 2016-05-17 US 9339488
Anti-cancer and Anti-obesity Cyclic Peptide Agents Hongjie ZHANG Taiwan 2016-05-11 TW 1532749
Method of Using Rhein for Treating Fibrotic Conditions and Tumors Hongyan QIN, Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Shilin CHEN, Siu Wai TSANG, Dajian YANG, Aiping LU, Haitao XIAO Hong Kong 2016-03-03 HK 1189487
Method of Using Rhein for Treating Fibrotic Conditions and Tumors Hongyan QIN, Zhaoxiang BIAN, Sun Chi Albert CHAN, Hongxi XU, Shilin CHEN, Siu Wai TSANG, Dajian YANG, Aiping LU, Haitao XIAO China 2016-03-02 CN 103505448 B
Pharmaceutical composition and methods for modulating immune system, preventing, pretreating and/or treating cancers Quanbin HAN United States 2016-02-23 US 9265810
Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2015
Anti-Cancer Agents Synthesized Based on Miliusane Compounds Hongjie ZHANG United States 2015-12-15 US 9211333
Oxanorbornadiene Derivatives and Their Anticancer Activities Zhaoxiang BIAN, Chengyuan LIN, Baomin FAN, Huaixue MU, Yongyun ZHOU, Weimin ZENG , Aiping LU, Sun Chi Albert CHAN United States 2015-09-01 US 9120816
Chinese medicinal formulation for treating inflammatory bowel disease and the preparation thereof BIAN Zhaoxiang, TSANG Siu Wai, IP Siu Po, WU Che Yuen Justin, LU Aiping, CHAN Albert Sun-Chi United States 2015-06-02 US 9044502 B2
Pharmaceutical Composition and Methods for Modulating Immune System, Preventing, Pretreating and/or Treating Cancers Quanbin HAN United States 2015-04-14 US 9005676
A Quality Control Marker and Its Use in Herbs Authentication Quanbin HAN, Hubiao CHEN, Jun XU United States 2015-04-07 US 8999719 B2
Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2014
A Fish Feed Containing Traditional Chinese Herbs for the Prevention of Enteritis in Grass Carps Ming Hung WONG, Wai Ming CHOI, Wing Yin MO, Zhaoxiang BIAN, Nai Ki MAK, Yicong GUO, Shengchun WU China 2014-09-24 ZL 201110039816.1
Asymmetric Synthesis of Norcantharidin Analogues by Alkynylation of Oxabenzonorbornadienes and Their Anticancer Activities Sun Chi Albert CHAN, Baomin FAN, Jun WANG, Chengyuan LIN, Chao HUANG, Qingjing YANG, Jianbin XU, Zhaoxiang BIAN, Aiping LU, Jun HU United States 2014-09-16 US 8835658 B2
Novel Formulation of Dehydrated Lipid Vesicles for Controlled Release of Active Pharmaceutical Ingredient via Inhalation YANG Zhijun, HUANG Wenhua, WONG Chi Sun, ZHAO Zhongzhen China 2014-04-16 ZL 200810210952.0
Method of Using Rhein for Treating Fibrotic Conditions and Tumors BIAN Zhaoxiang, TSANG Siu Wai, LU Aiping, XIAO Haitao, QIN Hongyan, CHAN Albert Sun-Chi, XU Hongxi, CHEN Shilin, YANG Dajian United States 2014-02-18 US 8652540 B2
Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2012
Chemical Preparation of a New Ginsenoside Dihydroginsenoside Rg2 and its Application Zhihong JIANG China 2012-01-11 CN 101397327A
Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2011
A Fish Feed Containing Traditional Chinese Herbs for the Prevention of Enteritis in Grass Carps Ming Hung WONG, Wai Ming CHOI, Wing Yin MO, Zhaoxiang BIAN, Nai Ki MAK, Yicong GUO, Shengchun WU Hong Kong S.A.R. 2011-07-08 HK 1146782
Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2010
Chinese Medicine Compositions and the Extraction for Gastrointestinal Disorders and Their Applications BIAN Zhaoxiang, SUNG Joseph J. Y., LEUNG Waikeung, LIU Liang, Che Yuen Justin WU Hong Kong S.A.R. 2010-10-15 HK 1118014
Chinese Medicine Compositions and the Extraction for Gastrointestinal Disorders and Their Applications BIAN Zhaoxiang, SUNG Joseph J. Y., LEUNG Waikeung, LIU Liang, Che Yuen Justin WU China 2010-05-12 CN 101176777 B
Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2009
Herbal Formulations for Arthritis LIU Liang, ZHOU Hua, WONG Yuen Fan Hong Kong S.A.R. 2009-12-11 HK 1088562
Saponins Derived from Ilex Pubescens and Method of Purifying the Same LIU Liang, WANG Jing Rong, ZHOU Hua, JIANG Zhi Hong United States 2009-06-09 US 7544668 B2
Herbal Formulations for Arthritis LIU Liang, ZHOU Hua, WONG Yuen Fan China 2009-06-03 CN100493589C
Name of Invention Inventor(s) Jurisdiction Issue Date Patent No.
2008
Hemiterpene Glycosides with Anti-platelet Aggregation Activities from Ilex Pubescens LIU Liang, JIANG Zhihong, LI Min, WANG Jingrong, LIU Zhongqiu United States 2008-09-02 US 7419960 B2

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