Dr Zhang Ge, Associate Director of Teaching Division and Deputy Director of the Institute for Advancing Translational Medicine in Bone and Joint Diseases of the School of Chinese Medicine, recently won the first prize of the 2013 Beijing Science and Technology Award for a collaborative project with the Institute of Radiation Medicine, Academy of Military Medical Sciences in Beijing.
Researchers working on the award-winning project entitled “Investigation of molecular function, regulatory mechanism and disease correlation of ubiquitin ligases” found that the “CKIP-1” factor can inhibit bone formation while the “SCFFBXL15” can enhance bone formation. Meanwhile, the delivery system “(DSS)6-liposome” promotes bone anabolic action of osteogenic siRNAs. In addition, researchers have also discovered the critical mechanism of certain ubiquitin ligases (eg. APC/C and SIAH1) in tumour progression.
Dr Zhang said that the project has revealed the molecular function, regulatory mechanism and disease correlation of ubiquitin ligases and has identified various potential molecule targets for the therapy of osteoporosis and tumours, thereby paving the way for targeted translational medicine research. He regarded the award as a recognition of the contribution of his team, which will continue to spare no efforts in conducting research in the pursuit of the development of effective new drugs to benefit mankind.
Dr Zhang Ge wins the first prize of the Beijing Science and Technology Award for his collaborative project which provides new implications for related research on bones